Results 151 to 160 of about 37,055 (264)

Nonlinear stiffness of NompC gating spring and its implication in mechanotransduction. [PDF]

Sci Adv
Wang Y, Jin P, Kumar A, Jan L, Cheng Y, Jan YN, Zhang Y.   +6 more
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Sticky Yet Slippery: Molecular Ordering Reconciles Bubble‐Surface Affinity With Ultralow Friction at the Nanoscale

Advanced Science, EarlyView.
By engineering the molecular order and thickness of PDMS layers, we reconcile the stickiness and slipperiness during bubble transport. AFM measurements and MD simulations further reveal how these nanoscale architectures tune hydrophobic interaction FHB and friction force f.
Shishuang Zhang, Jiajun Li, Huadong Tian, Zhoujie Wang, Chenyu Qiao, Jingyi Wang, Lei Xie, Hongbo Zeng   +7 more
wiley   +1 more source

Impacts of Tethered Logging Equipment on Soil Compaction, Moisture and Seedling Growth. [PDF]

For Sci
Chung W, Reuter RJ, Morrissette BA, Leshchinsky BA, Bladon KD, Hatten JA, Gonzalez-Benecke CA.   +6 more
europepmc   +1 more source

A Worm‐Inspired Origami Robot with Multimodal Locomotion for Adaptive Mobility in Complex Pipeline Environments

Advanced Science, EarlyView.
An origami worm‐inspired robot achieves multimodal locomotion in confined pipelines through mechatronic integration that embeds actuation, control, and communication within each origami module. Large, reversible configuration and dimensional changes enable 25 gaits synthesized by a unified framework across peristaltic, inchworm, and wheel‐rolling modes
Qiwei Zhang, Kangning Tan, Zihan He, Hongsen Pang, Yanjie Wang, Hongbin Fang, Jian Xu   +6 more
wiley   +1 more source

Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid). [PDF]

ACS Med Chem Lett
Sells CA, Kostyo JH, Gaykar RN, Kara MI, Lallande AT, Kane RR.   +5 more
europepmc   +1 more source

Wireless, Deep‐Seeing Smart Pill: A NIR‐II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer

Advanced Science, EarlyView.
A novel near‐infrared‐II fluorescent imaging capsule endoscope that detects specific fluorescence signals above 900 nm enables highly sensitive, targeted imaging of gastrointestinal cancer tissue. This wirelessly powered and magnetically controlled “smart pill” achieves high sensitivity and deep tissue penetration, allowing precise, non‐invasive ...
Weicheng Wang, Jinlei Jiang, Zhengting Wang, Shuqi Liu, Wei Wang, Xi Chen, Qirui Zhao, Xinyuan Cui, Cheng Zhou, Shengsheng Cui, Daxiang Cui   +10 more
wiley   +1 more source

Siloxane-tethered poly(2-ethyl-2-oxazoline) as surface modifying additives for anti-fouling silicones. [PDF]

Eur Polym J
Hernández JN, Palacharla AS, Kanu DK, Stafslien SJ, Wal LV, Grunlan MA.   +5 more
europepmc   +1 more source

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms. [PDF]

EMBO J
Hunker O, Bleichert F.
europepmc   +1 more source