Results 211 to 220 of about 90,627 (259)

Dysregulation of a novel autophagosome-mitochondria contact contributes to tauopathy-related neurodegeneration by disrupting autophagy. [PDF]

Autophagy
Jia N, Zuo Y, Guan H, Rajapaksha G, Cai Q.   +4 more
europepmc   +1 more source

CircFAM65A/CANX Condensates Sequester FAM134B to Inhibit ER‐phagy and Suppress Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Wenxiu Ru, Lunbiao Gan, Yu Lu, Yujing Guo, Qian Huang, Sha Yin, Fengze Nie, Sijia Di, Jiaqi Ning, Siyu Yao, Huanhuan Wan, Le Liu, Zehua Liu, Fa Yang, Weijun Qin, Weihong Wen   +15 more
wiley   +1 more source

Membrane-Associated Biomolecules for Synthetic Cell Signalling. [PDF]

Chembiochem
Dack C, Li B, Newell C, Booth MJ.
europepmc   +1 more source

3′‐UTR Hypermethylation and ABA Signaling Coordinate Transcriptional Activation of SWEET14 for High Sugar Accumulation in Citrus

Advanced Science, EarlyView.
Hypermethylation of CliSWEET14 3′‐UTR relieves ClibHLH105‐mediated transcriptional repression, together with ABA signaling‐mediated activation of the CliABF3‐CliNAC56 cascade, boosts CliSWEET14 expression and sucrose accumulation in citrus. ABSTRACT Sugar accumulation is pivotal for fruit quality, yet the molecular regulation of this process remains ...
Yike Zeng, Yue Wang, Yilei Wang, Haowei Chen, Qiyu Chen, Wei Xiao, Aoqing Zhang, Xin Jiang, Xiangming Shang, Zhicheng Yang, Xi Zeng, Wenqiang Hu, Chunlong Li, Ji‐Hong Liu   +13 more
wiley   +1 more source

Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review). [PDF]

Mol Med Rep
Meng S, Fu X, Xu Y, Peng Z, Zhang X, Cao Y, Tang B, Shi X, Liu K.   +8 more
europepmc   +1 more source

A Damage‐Gated Small‐Molecule Chimera Selectively Enhances Mitophagy by Coupling Dysfunctional Mitochondria to Autophagy

Advanced Science, EarlyView.
MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov, Ekaterina А. Guseva, Alexander Yu. Rudenko, Konstantin G. Lyamzaev, Sofya Y. Sokolskaya, Julia A. Golubeva, Maria V. Belopolskaya, Nadezda V. Andrianova, Olga V. Fadeeva, Elena О. Morgun, Elena A. Tukhovskaya, Marina S. Kazakova, Vladimir M. Pavlov, Daria K. Yagoda, Elena I. Marusich, Rose‐Lys Zaranaina, Valeriya B. Vays, Irina M. Vangeli, Egor Y. Plotnikov, Maxim L. Lovat, Lora E. Bakeeva, Arkady N. Murashev, Vladimir I. Polshakov, Olga A. Dontsova, Peter V. Sergiev   +24 more
wiley   +1 more source

Functional, Radiographic, and Patient-Reported Outcomes of Hybrid Fixation Versus Posterior Long Fusion for Double-Major Adolescent Idiopathic Scoliosis. [PDF]

J Clin Med
Abay B, Arsoy SE, Mraja HM, Dolas I, Enercan M, Hamzaoglu A.   +5 more
europepmc   +1 more source

Membrane‐Targeted Nanoparticles for Neuronal Photomodulation

Advanced Science, EarlyView.
Immobilizing gold nanoparticles on the neural interface using a bioorthogonal approach generates localized heat upon exposure to near‐infrared light, temporarily inhibiting primary neuronal activity without damaging the cells. This precise placement and retention of nanoparticles at the cell membrane expand the strategies for non‐invasive neural ...
Ane Escobar, Ana Sánchez‐Iglesias, Davide Bello, Miriam Feijoo Barriga, Alex M. Ascensión, Laura Rodríguez‐Gómez, David Otaegui‐Bichot, Francisco Javier Gil‐Bea, Monica Carril, Marek Grzelczak   +9 more
wiley   +1 more source

Amphiphilic Lipid-Single-Stranded DNA Conjugate-Mediated Cell Surface Engineering for Programmable Intercellular Tethering and Immune Synapse Formation. [PDF]

Biomater Res
Kim S, Lee CE, Jangid AK, Kim K.
europepmc   +1 more source

Bacterial Geosmin Biosynthesis is Compartmentalized Inside a Two‐Component Protein Shell

Advanced Science, EarlyView.
This study reports the discovery that geosmin biosynthesis is compartmentalized inside a two‐component protein shell in many bacteria. Sequestration of geosmin synthase inside a Family 2B encapsulin nanocompartment improves geosmin yield and increases enzyme stability as compared to the free enzyme.
Asif Fazal, Cassandra A. Dutcher, Michael P. Andreas, Tobias W. Giessen   +3 more
wiley   +1 more source