Results 111 to 120 of about 208,254 (312)
Mapping the structural change caused by tetracycline binding to the ykkCD antibiotic sensor RNA
, 2013 Riboswitches are naturally occurring RNA aptamers that form a precise three-dimensional structure and selectively bind to cellular target molecules. Binding of the target molecule initiates an allosteric structural change in the riboswitch that in turn
Howell, Laura Ashley
core
Tetracycline-Inactivating Enzymes
, 2018 Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis and strategic scaffold modifications designed to overcome established
Timothy A. Wencewicz, Jana L. Markley
core +1 more source
Stochastic simulations of the tetracycline operon [PDF]
, 2011 Background The tetracycline operon is a self-regulated system. It is found naturally in bacteria where it confers resistance to antibiotic tetracycline.
Yiannis N Kaznessis +2 more
core +1 more source
What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?
Biotechnology and Bioengineering, EarlyView.Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady +6 more
wiley +1 more source
Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders
BiomoleculesNeutrophil-mediated inflammation is a key feature of immune-mediated chronic skin disorders, but the mechanistic understanding of neutrophil involvement in these conditions remains incomplete.
Ludovica Franceschin +6 more
doaj +1 more source
Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production
Biotechnology and Bioengineering, EarlyView.ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise +3 more
wiley +1 more source
Tetx2-A Tetracycline Inactivating Enzyme [PDF]
, 2003 Resistance to the tetracycline antibiotics occurs primarily by efflux and ribosome protection mechanisms, however a tetracycline inactivating enzyme, TetX, was identified 15 years ago, although little is known about this mechanism. The gene encoding this
Yang, Wangrong
core +1 more source
, 2007 The aims of the present study were to investigate at the farm-owner level the effect of prescribed tetracycline consumption in pigs and different Salmonella Typhimurium phage types on the probability that the S. Typhimurium was resistant to tetracycline.
Vieira, Antonio +5 more
core +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg +8 more
wiley +1 more source
Cocontamination with tetracycline (TC) and arsenic (As) is very common in paddy fields. However, the process and underlying mechanism of arsenite (As(III)) transformation on iron mineral surfaces in the presence of antibiotic contaminants remain unclear.
Liping Fang (776115) +8 more
core +1 more source