Results 41 to 50 of about 139,661 (236)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Tertiary-Treated Municipal Wastewater is a Significant Point Source of Antibiotic Resistance Genes Into Duluth-Superior Harbor [PDF]

, 2011
In this study, the impact of tertiary-treated municipal wastewater on the quantity of several antibiotic resistance determinants in Duluth-Superior Harbor was investigated by collecting surface water and sediment samples from 13 locations in Duluth ...
Allen H. K., Alonso A., Amann R. I., Andersson D. I., Arthurson V., Auerbach E. A., Benson D. A., Berhardt A. E., Berhardt A. E., Canton R., Cardinale M., Chopra I., Cotner J. B., David T. Tan, Davies J., Diehl D. L., D’Costa V. M., Ghosh S., Graham D. W., Jessica J. Eichmiller, Levy S. B., Levy S. B., Ling L. L., Lipsitch M., Martínez J., Merlin C., Mi Yan, Moura A., Munir M., Nelson D. K., Novo A., Patrick J. McNamara, Pruden A., Ramsden S. J., Sambrook J., Seurinck S., Smith D. L., Sommer M. O. A., Staley J. T., Storteboom H., Tchobanoglous G., Thioulouse J., Thompson J. D., Timothy M. LaPara, Tucker R. Burch, Xi C., Yi L., Zhang T., Zhang X., Zhang X.-X.   +49 more
core   +3 more sources

Preparation of copper modified biochar and its effect on catalyzing persulfate to remove the tetracycline from water

Gongye shui chuli
Copper modified corn stalk biochar(CBC) was prepared by hydrothermal method and used as a catalyst to activate potassium persulfate(PS) to remove tetracycline (TC) from water. The results showed that CBC+PS system had high efficiency and stability for TC
FAN Xiulei, WANG Shenpeng, ZHANG Shu, JI Wei, CUI Yue, KONG Xizhe, LÜ Bowen   +6 more
doaj   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Regulation of the putative ykkCD riboswitch by tetracycline and related antibiotics in Bacillus subtilis [PDF]

, 2013
Multi-drug resistance among bacterial pathogens can be mediated by a number of mechanisms, including multidrug efflux pumps. One such pump in Bacillus spp. is ykkCD, a heterodimer of the SMR family consisting of C and D subunits.
Frecker, Nicholas L.
core   +2 more sources

Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels [PDF]

, 2001
Mitochondrial respiration in the African trypanosome undergoes dramatic developmental stage regulation. This requires co-ordinated control of components encoded by both the nuclear genome and the kinetoplast, the unusual mitochondrial genome of these ...
Benne R., Beverley S.M., Brun R., Carruthers V.B., Czichos J., Feagin J.E., Folsch H., Hahne K., Hauser R., Hausler T., Hirumi H., Kwast K.E., LeBowitz J.H., Matthews K.R., Osinga K.A., Overath P., Priest J.W., Roditi I., Sherwin T., Smagula C., Sogin M.L., Stuart K., Tasker M., Torri A.F., Tschudi C., Ullu E., Vassella E., Wirtz E., Woods A., Ziegelbauer K.   +29 more
core   +1 more source

Presence of Tetracycline and Sulfonamide Resistance Genes in Salmonella spp.: Literature Review

Antibiotics, 2021
Tetracyclines and sulfonamides are broad-spectrum antibacterial agents which have been used to treat bacterial infections for over half a century. The widespread use of tetracyclines and sulfonamides led to the emergence of resistance in a diverse group ...
Sabrina Lunara Santos Pavelquesi, Ana Carolina Almeida de Oliveira Ferreira, Angeislenie Ricelle Magalhães Rodrigues, Calliandra Maria de Souza Silva, Daniela Castilho Orsi, Izabel Cristina Rodrigues da Silva   +5 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Insertion of T4-lysozyme (T4L) can be a useful tool for studying olfactory-related GPCRs. [PDF]

, 2012
The detergents used to solubilize GPCRs can make crystal growth the rate-limiting step in determining their structure. The Kobilka laboratory showed that insertion of T4-lysozyme (T4L) in the 3rd intracellular loop is a promising strategy towards ...
Baaske, Baud, Brian L. Cook, Cherezov, Chien, Christoph J. Wienken, Cook, Cook, Corin, Corin, Dahoun, Dieter Braun, Duhr, Garavito, Gimelbrant, Gimelbrant, Greenfield, Hanson, Horst Pick, Horst Vogel, Jaakola, Jacquier, Jayadev, Karolina Corin, Katada, Loll, Lu, Lu, McClintock, Philipp Baaske, Pick, Rasmussen, Ren, Rodriguez, Shimamura, Shirokova, Shuguang Zhang, Spehr, Spehr, Stefan Duhr, Wallin, Warne, Wienken, Wu   +43 more
core   +1 more source

Effect of Sarecycline on the Acne Symptom and Impact Scale and Concerns in Moderate-to-Severe Truncal Acne in Open-Label Pilot Study

Antibiotics, 2023
Truncal acne is common, and the psychosocial burden may be underestimated as patients most often complain of facial acne. The Acne Symptom and Impact Scale (ASIS) is a 17-item patient-reported outcome (PRO) measure designed to assess the signs and ...
Angela Yen Moore, Kara Hurley, Stephen Andrew Moore, Luke Moore, Ilana Zago   +4 more
doaj   +1 more source