The Role of Tetraether Lipid Composition in the Adaptation of Thermophilic Archaea to Acidity [PDF]
Frontiers in Microbiology, 2013 Diether and tetraether lipids are fundamental components of the archaeal cell membrane. Archaea adjust the degree of tetraether lipid cyclization in order to maintain functional membranes and cellular homeostasis when confronted with pH and/or thermal ...
Eric eBoyd +4 more
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Discovery, structure and mechanism of a tetraether lipid synthase. [PDF]
Nature, 2022 Abstract Archaea synthesize isoprenoid-based ether-linked membrane lipids, which enable them to withstand extreme environmental conditions, such as high temperatures, high salinity, and low or high pH values 1–5 .
Lloyd CT +6 more
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First Isolation and Structure Elucidation of GDNT‐β‐Glu – Tetraether Lipid Fragment from Archaeal Sulfolobus Strains [PDF]
ChemistryOpen, 2021 Due to their special chemical structure, tetraether lipids (TEL) represent essential elements of archaeal membranes, providing these organisms with extraordinary properties.
Dr. Alexander Scholte +7 more
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Biological Membranes in Extreme Conditions: Simulations of Anionic Archaeal Tetraether Lipid Membranes. [PDF]
PLoS ONE, 2016 In contrast to the majority of organisms that have cells bound by di-ester phospholipids, archaeal membranes consist of di- and tetraether phospholipids.
Luis Felipe Pineda De Castro +2 more
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Structure-function relationships in pure archaeal bipolar tetraether lipids. [PDF]
Chem Sci, 2023 A series of archaeal bipolar glycerol dialkyl glycerol tetraether (GDGT) lipids were synthesized. Structural properties of self-assembled structures of GDGTs were studied and related to functional behavior such as membrane fusion.
Bhattacharya A +6 more
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Molecular dynamics study of bipolar tetraether lipid membranes. [PDF]
Biophys J, 2005 Membranes composed of bipolar tetraether lipids have been studied by a series of 25-ns molecular dynamics simulations to understand the microscopic structure and dynamics as well as membrane area elasticity. By comparing macrocyclic and acyclic tetraether and diether archaeal lipids, the effect of tail linkage of the two phytanyl-chained lipids on the ...
Shinoda W, Shinoda K, Baba T, Mikami M.
europepmc +4 more sources
On physical properties of tetraether lipid membranes: effects of cyclopentane rings. [PDF]
Archaea, 2012 This paper reviews the recent findings related to the physical properties of tetraether lipid membranes, with special attention to the effects of the number, position, and configuration of cyclopentane rings on membrane properties. We discuss the findings obtained from liposomes and monolayers, composed of naturally occurring archaeal tetraether lipids
Chong PL, Ayesa U, Daswani VP, Hur EC.
europepmc +4 more sources
Novel Extended Tetraether Lipids Found in a High-CO<sub>2</sub> Geyser. [PDF]
Environ MicrobiolCharacterisation of the archaeal lipidome of the CO2‐rich subsurface aquifer of the Geyser Andernach reveals novel extended tetraether lipids analogous to extended archaeols, likely produced by Candidatus Altiarchaeum, and potentially functioning as a membrane adaptation strategy to nutrient‐deprived conditions.
Groninga J +8 more
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Oral delivery of vancomycin by tetraether lipid liposomes
European Journal of Pharmaceutical Sciences, 2017 Despite the outstanding progress in modern medicine, the oral delivery of peptide drugs is limited until today due to their instability in the gastrointestinal tract and low mucosa penetration. To overcome these hurdles, liposomes containing the specific tetraether lipid GCTE (glycerylcaldityltetraether lipid) were examined.
Philipp Uhl +2 more
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Engineering archaeal membrane‐spanning lipid GDGT biosynthesis in bacteria: Implications for early life membrane transformations [PDF]
mLifeEukaryotes are hypothesized to be archaeal–bacterial chimeras. Given the different chemical structures of membrane phospholipids in archaea and bacteria, transformations of membranes during eukaryogenesis that led to the bacterial‐type membranes of ...
Huahui Chen +9 more
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