Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5 [PDF]
, 2012 Cerebral blood flow (CBF) is known to be dysregulated in persons with human immunodeficiency virus 1 (HIV-1), for uncertain reasons. This is an important issue because impaired vasoreactivity has been associated with increased risk of ischemic stroke ...
Dewhurst, Stephen +10 more
core +2 more sources
Maintenance of cellular tetrahydrobiopterin homeostasis
BMB Reports, 2010 Tetrahydrobiopterin (BH4) is a multifunctional cofactor of aromatic amino acid hydroxylases and nitric oxide synthase (NOS) as well as an intracellular antioxidant in animals. Through regulation of NOS activity BH4 plays a pivotal role not only in a variety of normal cellular functions but also in the pathogenesis of cardiovascular and ...
Hye-Lim, Kim, Young Shik, Park
openaire +3 more sources
Pteridines, 1989 The catalytic activity of tyrosine 3-monooxygenase (tyrosine hydroxylase) is dependent on a tetrahydropterin cofactor and ezyme-bound iron. The oxidation of tetrahydrobiopterin by bovine adrenal tyrosine hydroxylase was studied by high performance liquid
Haavik Jan +3 more
doaj +1 more source
Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]
, 2009 Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd +32 more
core +5 more sources
Pterin Metabolism In Haemodialysis Patients
Pteridines, 1989 Patients undertaking maintenance haemodialysis may develop a variety of neurological disorders, the most serious of which is aluminium induced encephalopathy.
Altmann Paul +5 more
doaj +1 more source
Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries☆ [PDF]
, 2007 M. Worthley +6 more
openalex +1 more source
Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism
Pteridines, 1998 The influence of changes in catecholamine metabolism on tetrahydrobiopterin biosynthesis was investigated in cultured rat pheochromocytoma PC12 cells. The increase in the cellular dopamine content after treatment with the MAO-COMT inhibitor or dopamine ...
Kuzuya Hiroshi +2 more
doaj +1 more source
Dopa-Responsive Motor Disorder with Sepiapterin Reductase Deficiency
Pediatric Neurology Briefs, 2005 The clinical findings in 7 children from Malta, at first suspected to have cerebral palsy and later diagnosed with sepiapterin reductase deficiency, are reported from Great Ormond Street Hospital, London, UK, and St Luke’s Hospital, University of Malta.
J Gordon Millichap
doaj +1 more source
Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo [PDF]
, 2017 The recent approval of sapropterin dihydrochloride, the synthetic form of 6[R]-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4), for the treatment of phenylketonuria (PKU) as the first pharmacological chaperone drug initiated a paradigm change in the ...
Danecka, Marta K. +12 more
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