Results 111 to 120 of about 26,569 (299)

Ferroptosis in Osteoarthritis: Towards Novel Therapeutic Strategy

Cell Proliferation, Volume 58, Issue 3, March 2025.
Osteoarthritis (OA) is a chronic degenerative joint disease mainly characterised by articular cartilage damage, synovitis and persistent pain, and has become one of the most common diseases worldwide. In OA cartilage, various forms of cell death have been identified, including apoptosis, necroptosis and autophagic cell death.
Yiming Zhang, Jing Li, Jiane Liu, Yan Gao, Kehan Li, Xinyu Zhao, Yufeng Liu, Daijie Wang, Xiao Hu, Zheng Wang   +9 more
wiley   +1 more source

Stimulation of Tetrahydrobiopterin Synthesis by 17β-Estradiol in Brain Microvascular Endothelial Cells

Pteridines, 2000
The purpose of this study was to examine whether 17β-estradiol stimulates the synthesis of tetrahydrobiopterin : BH4), which is one of the cofactors of nitric oxide (NO) synthase, in mouse brain microvascular endothelial cells. Addition of 17()-estradiol
Shiota Kazuhiro, Ishii Masakazu, Yamamoto Toshinori, Shimizu Shunichi, Kiuchi Yuji   +4 more
doaj   +1 more source

Hypoxia and Reoxygenation Induce Endothelial Nitric Oxide Synthase Uncoupling in Endothelial Cells through Tetrahydrobiopterin Depletion and S-Glutathionylation

Biochemistry, 2014
Ischemia-reperfusion injury is accompanied by endothelial hypoxia and reoxygenation that trigger oxidative stress with enhanced superoxide generation and diminished nitric oxide (NO) production leading to endothelial dysfunction.
Francesco De Pascali, C. Hemann, Kindra Samons, Chun-an Chen, J. Zweier   +4 more
semanticscholar   +1 more source

The Current Advances in Design Strategy (Indirect Strategy and Direct Strategy) for Type‐I Photosensitizers

Advanced Science, Volume 12, Issue 7, February 17, 2025.
The current design strategies of type‐I PSs are summarized from two perspectives: indirect strategy (inhibiting EET process: reducing the energy of T1 to lower than the energy required for the excitation energy transfer to produce singlet oxygen) and direct strategy (enhancing ET process: promoting the ET efficiency to generate superoxide radicals ...
Ning Ma, Junjie Wang, Hui Tang, Shiyu Wu, Xiaochun Liu, Kangyao Chen, Yahui Zhang, Xiaoqi Yu   +7 more
wiley   +1 more source

Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications [PDF]

, 2015
SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the
Ana I. Casas, Andreas Daiber, Antonio Cuadrado, Brunner HG, Fabio Di Lisa, Ghassan J. Maghzal, Hampton MB, Harald H.H.W. Schmidt, Hou YC, Karl H. Krause, Klebanoff SJ., Liu VW, Manuela G. López, Nina Kaludercic, Pietro Ghezzi, Roland Stocker, Sandler M, Savenkova ML, Sonia Leach, Tamara Seredenina, V. Thao-Vi Dao, Vincent Jaquet   +21 more
core   +2 more sources

Three classes of tetrahydrobiopterin-dependent enzymes

Pteridines, 2013
Current knowledge distinguishes three classes of tetrahydrobiopterin-dependent enzymes as based on protein sequence similarity. These three protein sequence clusters hydroxylate three types of substrate atoms and use three different forms of iron for ...
Werner Ernst R.
doaj   +1 more source

Modulation of Radiation Response by the Tetrahydrobiopterin Pathway

Antioxidants, 2015
Ionizing radiation (IR) is an integral component of our lives due to highly prevalent sources such as medical, environmental, and/or accidental. Thus, understanding of the mechanisms by which radiation toxicity develops is crucial to address acute and ...
R. Pathak, A. Cheema, S. Boca, K. Krager, M. Hauer-Jensen, N. Aykin-Burns   +5 more
semanticscholar   +1 more source

Queuosine tRNA Modification: Connecting the Microbiome to the Translatome

BioEssays, Volume 47, Issue 2, February 2025.
tRNA queuosine modifications in mammalian cells are dependent on queuine produced by gut microbiome or from the diet. This gut‐tRNA axis provides an interesting link between gut health and tissue translatome and proteome regulation. Queuosine is essential for neurotransmitter synthesis, neuronal function, and is linked to neurodegenerative diseases as ...
Sherif Rashad
wiley   +1 more source

Early Diagnosis of 6-Pyruvoyl-tetrahydropterin Synthase Deficiency

Pteridines, 1994
6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency, which used to be called dihydrobiopterin synthase deficiency, is the most common kind of tetrahydrobiopterin deficiency. Early treatment by administration of tetrahydrobiopterin and neurotransmitter
Shintaku Haruo
doaj   +1 more source

New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia [PDF]

, 2016
Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy.
Gureev, V. V.
core   +2 more sources