The crystal structure of a bacterial, bifunctional 5, 10 methylene‐tetrahydrofolate dehydrogenase/cyclohydrolase [PDF]
Protein Science, 1999 AbstractThe structure of a bifunctional 5, 10‐methylene‐tetrahydrofolate dehydrogenase/cyclohydrolase from Escherichia coli has been determined at 2.5 Å resolution in the absence of bound substrates and compared to the NADP‐bound structure of the homologous enzyme domains from a trifunctional human synthetase enzyme.
B W, Shen +5 more
openaire +2 more sources
Comparative genomics and mutagenesis analyses of choline metabolism in the marine Roseobacter clade [PDF]
, 2015 Choline is ubiquitous in marine eukaryotes and appears to be widely distributed in surface marine waters; however, its metabolism by marine bacteria is poorly understood.
Andresen P.A. +6 more
core +1 more source
The correlation between MTHFD2 and the tumor microenvironment in head and neck squamous cell carcinoma [PDF]
Yixue xinzhi zazhiObjective To investigate the expression, biological function, related signaling pathways, tumor mutation burden (TMB), immune infiltration and prognosis of methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) in head and neck squamous carcinoma (HNSCC) by
SHI Zhenxiang +4 more
doaj +1 more source
Complete genome sequence of Syntrophobacter fumaroxidans strain (MPOB(T)). [PDF]
, 2012 Syntrophobacter fumaroxidans strain MPOB(T) is the best-studied species of the genus Syntrophobacter. The species is of interest because of its anaerobic syntrophic lifestyle, its involvement in the conversion of propionate to acetate, H2 and CO2 during ...
Crable, Bryan R +15 more
core +2 more sources
Changes in the microsomal proteome of tomato fruit during ripening [PDF]
, 2019 The variations in the membrane proteome of tomato fruit pericarp during ripening have been investigated by mass spectrometry-based label-free proteomics.
De Lorenzo, Giulia +6 more
core +1 more source
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. [PDF]
PLoS Genetics, 2010 Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE.
Adam C Naj +16 more
doaj +1 more source
An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement [PDF]
, 2019 The enzymes involved in folate metabolism are key drug targets for cell-growth modulation, and accurate crystallographic structures provide templates to be exploited for structure-based ligand design.
Bueno, Renata +2 more
core +2 more sources
Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]
, 2018 'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon +1 more
core +3 more sources
Serine one-carbon catabolism with formate overflow [PDF]
, 2016 Serine catabolism to glycine and a one-carbon unit has been linked to the anabolic requirements of proliferating mammalian cells. However, genome-scale modeling predicts a catabolic role with one-carbon release as formate. We experimentally prove that in
Athineos, Dimitris +11 more
core +1 more source
Adaptively evolved Escherichia coli for improved ability of formate utilization as a carbon source in sugar???free conditions [PDF]
, 2019 Background: Formate converted from CO2 reduction has great potential as a sustainable feedstock for biological production of biofuels and biochemicals.
A Alissandratos +46 more
core +1 more source