Pyridoxamine inhibits dopamine-induced α-synuclein oligomerization through scavenging neurotoxic dopamine quinone. [PDF]
Sci RepLee SH +4 more
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New tetrahydroisoquinolines bearing nitrophenyl group targeting HSP90 and RET enzymes: synthesis, characterization and biological evaluation. [PDF]
BMC ChemBakhite EA +4 more
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Copper and electrocatalytic synergy for the construction of fused quinazolinones with 2-aminobenzaldehydes and cyclic amines. [PDF]
RSC AdvShi Y, Li G, Wang R, Zhao XJ, He Y.
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Isolation and quantification of polyphenolics, exploration of antioxidant, cytotoxicity, and wound healing activities of Pithecellobium dulce (Roxb.) Benth. [PDF]
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Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain
Biochemical and Biophysical Research Communications, 1986This is the first report to identify 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain. The detection was performed by coupled gas chromatography - multiple ion detection, using heptafluorobutyric anhydride and pentafluoropropionic anhydride as derivatizing reagents.
Masaaki Hirobe, Michihiro Kohno
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Tetrahydroisoquinolines: A review
Progress in Neuro-Psychopharmacology, 1981Abstract 1. 1. This article reviews some important aspects concerning the chemistry, biochemistry, and pharmacology of Tetrahydroisoquinolines. 2. 2. Special attention is given to the hypothesis which attempts to explain the physiopathology of certain behavioral disorders observed after chronic ingestion of alcohol. 3. 3.
M E, Zarranz de Ysern, L A, Ordoñez
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Multicomponent Synthesis of Tetrahydroisoquinolines
Organic Letters, 2018A multicomponent synthesis of tetrahydroisoquinolines from carboxylic acids, alkynyl ethers, and dihydroisoquinolines is described. This process features readily available starting materials, simple experimental procedures for achievement of molecule complexity, and structural diversity. The preliminary control experiment and crossover reaction provide
Linwei Zeng +3 more
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Biosynthesis of Tetrahydroisoquinoline Antibiotics
Current Topics in Medicinal Chemistry, 2016The tetrahydroisoquinoline (THIQ) alkaloids are naturally occurring antibiotics isolated from a variety of microorganisms and marine invertebrates. This family of natural products exhibit broad spectrum antimicrobial and strong antitumor activities, and the potency of clinical application has been validated by the marketing of ecteinascidin 743 (ET-743)
Gong-Li, Tang +3 more
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Tetrahydroisoquinolines and the serotonergic system
Drug and Alcohol Dependence, 1979Abstract Although its oxidation to acetate overwhelmingly predominates, acetaldehyde (ACH) formed during ethanol metabolism can be “trapped” by condensation with catecholamines (CAs) or DOPA. The condensation products, tetrahydroisoquinolines (TIQs), have been detected in the brains of mice chronically exposed to ethanol [1] and in the urine of ...
J J, Hannigan, M A, Collins
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