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Optimized synthesis of tetrahydroisoquinoline-hydantoins
Tetrahedron Letters, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Julie Charton +4 more
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Synthesis of novel tetrahydroisoquinoline bronchodilators
Bioorganic & Medicinal Chemistry Letters, 2010The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD4 contracted isolated human small airways ex-vivo. Several compounds demonstrated highly efficacious bronchorelaxing properties.
Maria F, Dalence-Guzmán +4 more
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Pictet–Spengler tetrahydroisoquinoline synthesis
2009Tetrahydroisoquinolines from condensation of β-arylethylamines and carbonyl compounds followed by cyclization.
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Journal of the Chemical Society, Perkin Transactions 2, 1990
The isomerization of 1,2,3,4-tetrahydroisoquinoline to 5,6,7,8-tetrahydroisoquinoline proceeded over Raney nickel at ca. 200 °C under hydrogen and nitrogen pressure in a closed reactor. Based on kinetic analyses and quantum chemical calculations we propose that the isomerization proceeds through a series of consecutive steps where dehydrogenation and ...
Hiroshi Okazaki +3 more
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The isomerization of 1,2,3,4-tetrahydroisoquinoline to 5,6,7,8-tetrahydroisoquinoline proceeded over Raney nickel at ca. 200 °C under hydrogen and nitrogen pressure in a closed reactor. Based on kinetic analyses and quantum chemical calculations we propose that the isomerization proceeds through a series of consecutive steps where dehydrogenation and ...
Hiroshi Okazaki +3 more
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Regioselective Allylation to a Tetrahydroisoquinoline
HETEROCYCLES, 1992The p-quinol acetate (1a) reacted with allyltrimethylsilane in dichloromethane in the presence of acid (BF 3 .Et 2 O or CF 3 COOH) to give 8-allylcorypalline (3), while in acetonitrile to give 4-allylcorypalline (7), regioselectively.
Osamu Hoshino, Hiroshi Hara, Akiko Seto
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[Tetrahydroisoquinoline and parkinsonism].
Rinsho shinkeigaku = Clinical neurology, 1990In squirrel monkeys (n = 13), 20 mg/kg/day of TIQ was injected subcutaneously for 43 to 104 days. Behavioral scores of motor disturbance were analysed; ranging from 20/45 to 30/45 (mean 27.8 +/- 4.18). Dopamine, total biopterine and tyrosine hydroxylase (TH) were decreased in the substantia nigra of TIQ treated monkeys compared to saline treated ...
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The Tetrahydroisoquinoline Oxidative Rearrangement
HETEROCYCLES, 1978Hiroshi Hara +3 more
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Bis-tetrahydroisoquinoline derivatives
European Journal of Medicinal Chemistry, 2010Crystal structure of the three stereoisomers of 1,1′-(propane-1,3- diyl)-bis-(6,7-dimethoxy-2-methyl- 1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.
Wouters, Johan +4 more
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The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines
ChemCatChem, 2023Helen Hailes +2 more
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