Results 111 to 120 of about 1,536 (171)

Regioselective α-Phosphonylation of Unprotected Alicyclic Amines. [PDF]

Org Lett
Li B, Yu F, Chen W, Seidel D.
europepmc   +1 more source

Cooperative NHC and Photoredox Dual Catalysis for the Construction of Carbonyl Compounds. [PDF]

ACS Omega
Dhayalan V.
europepmc   +1 more source

Multifunctional kojic acid-tetrahydroisoquinoline hybrids: Synthesis, tyrosinase inhibition, and applications in the anti-browning of fresh-cut mushrooms. [PDF]

Curr Res Food Sci
Lv M, Cao L, Ding Y, Gao S, Wu Y, Li R, Tang W, Zhu L.   +7 more
europepmc   +1 more source

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Tetrahydroisoquinolines: A review

Progress in Neuro-Psychopharmacology & Biological Psychiatry, 1981
Abstract 1. 1. This article reviews some important aspects concerning the chemistry, biochemistry, and pharmacology of Tetrahydroisoquinolines. 2. 2. Special attention is given to the hypothesis which attempts to explain the physiopathology of certain behavioral disorders observed after chronic ingestion of alcohol. 3. 3.
M E, Zarranz de Ysern, L A, Ordoñez
exaly   +3 more sources

Tetrahydroisoquinolines as MCH-R1 antagonists

Bioorganic and Medicinal Chemistry Letters, 2006
A series of potent and selective inhibitors of h-MCH-R1 has been developed based on the piperidine glycineamide compounds I and II. These structurally more rigid tetrahydroisoquinolines (III and IV) showed better pharmacokinetics. The highly potent compounds 12d and 12g displayed excellent rat pk.
M Van Heek, W J Greenlee
exaly   +3 more sources

Multicomponent Synthesis of Tetrahydroisoquinolines

Organic Letters, 2018
A multicomponent synthesis of tetrahydroisoquinolines from carboxylic acids, alkynyl ethers, and dihydroisoquinolines is described. This process features readily available starting materials, simple experimental procedures for achievement of molecule complexity, and structural diversity. The preliminary control experiment and crossover reaction provide
Linwei Zeng, Bo Huang, Yangyong Shen, Sunliang Cui   +3 more
openaire   +2 more sources

Biosynthesis of Tetrahydroisoquinoline Antibiotics

Current Topics in Medicinal Chemistry, 2016
The tetrahydroisoquinoline (THIQ) alkaloids are naturally occurring antibiotics isolated from a variety of microorganisms and marine invertebrates. This family of natural products exhibit broad spectrum antimicrobial and strong antitumor activities, and the potency of clinical application has been validated by the marketing of ecteinascidin 743 (ET-743)
Gong-Li, Tang, Man-Cheng, Tang, Li-Qiang, Song, Yue, Zhang   +3 more
openaire   +2 more sources

Tetrahydroisoquinolines and the serotonergic system

Drug and Alcohol Dependence, 1979
Abstract Although its oxidation to acetate overwhelmingly predominates, acetaldehyde (ACH) formed during ethanol metabolism can be “trapped” by condensation with catecholamines (CAs) or DOPA. The condensation products, tetrahydroisoquinolines (TIQs), have been detected in the brains of mice chronically exposed to ethanol [1] and in the urine of ...
J J, Hannigan, M A, Collins
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Accumulation of a Tetrahydroisoquinoline in Phenylketonuria

Science, 1979
3′,4′-Deoxynorlaudanosolinecarboxylic acid (DNLCA), a tetrahydroisoquinoline derived from dopamine and phenylpyruvic acid, has been detected by computerized mass fragmentography in urine of phenylketonuric children and in urine and brain of rats with experimentally induced hyperphenylalaninemia.
J M, Lasala, C J, Coscia
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Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain

Biochemical and Biophysical Research Communications, 1986
This is the first report to identify 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain. The detection was performed by coupled gas chromatography - multiple ion detection, using heptafluorobutyric anhydride and pentafluoropropionic anhydride as derivatizing reagents.
M, Kohno, S, Ohta, M, Hirobe
openaire   +2 more sources