Results 191 to 200 of about 5,031 (222)

Inhibition of Vasoconstriction by Tetramethylpyrazine

Journal of Cardiovascular Pharmacology, 1990
Using dog mesenteric arterial ring preparations, we studied the in vitro vascular effects of tetramethylpyrazine (TMP, also known as Ligustrazine), a vasoactive component derived from Ligustium Wollichii Franchat; a widely used ingredient in Chinese herbal medicine for the treatment of cardiovascular diseases.
C Y, Kwan, E E, Daniel, M C, Chen
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Tetramethylpyrazine in the Treatment of Cardiovascular and Cerebrovascular Diseases

Planta Medica, 1983
S K, Guo, K J, Chen, Z H, Qian, W L, Weng, M Y, Qian   +4 more
exaly   +4 more sources

[Studies on the metabolites of tetramethylpyrazine in rabbits].

Yao xue xue bao = Acta pharmaceutica Sinica, 1998
The metabolites of tetramethylpyrazine (TMPz) in rabbit have been separated by HPLC and solvent extraction. Their structures were identified by means of UV, IR, MS and NMR spectroscopy. The possible metabolic ways of TMPz are oxidzation of one of the four methyl groups to hydroxymethyl and carboxyl group forming 2-hydroxymethyl-3, 5, 6 ...
X, Chen, S N, Dong
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[Protective mechanism of tetramethylpyrazine on cardiovascular system].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023
Tetramethylpyrazine is the main component of Ligusticum chuanxiong. Studies have found that tetramethylpyrazine has a good protective effect against cardiovascular diseases. In the heart, tetramethylpyrazine can reduce myocardial ischemia/reperfusion injury by inhibiting oxidative stress, regulating autophagy, and inhibiting cardiomyocyte apoptosis ...
Chun-Kun, Yang, Qing-Quan, Pan, Kui, Ji, Chuan-Chao, Luo, Zhuang, Tian, Hong-Yuan, Zhou, Jun, Li   +6 more
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Effects of Tetramethylpyrazine on Isolated Atria of the Guinea-Pig

Planta Medica, 1981
The chronotropic and inotropic effects of tetramethylpyrazine (TMPZ) obtained from the stem of JATROPHA PODAGRICA H OOK (Euphorbiaceae) have been investigated on guinea-pig isolated atria. TMPZ caused negative chronotropic and inotropic responses on the isolated atria of guinea-pigs.
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Effect of Tetramethylpyrazine on Reserpine-Induced Gastric Lesion in Rats

Digestive Diseases and Sciences, 1998
The present study was undertaken to determine the effect of tetramethylpyrazine administered intraperitoneally on gastric lesions, gastric acid secretion, gastric barrier mucus secretion, and gastric contraction in reserpine-treated rats. The results of this study demonstrated that tetramethylpyrazine at doses of 0.5, 1, 10, and 20 mg/kg significantly ...
J L, Wan, C L, Wang, Q D, Chang
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Paramagnetic Resonance of the Triplet State of Tetramethylpyrazine

The Journal of Chemical Physics, 1967
EPR measurements are reported for solid solutions of tetramethylpyrazine (TMP) in durene under ultraviolet irradiation at 77°K. The fine structure of the paramagnetic resonance spectrum observed at 9.2 and 35 GHz may be described by the spin Hamiltonian H=gβH·S+DSz2+E(Sx2−Sy2) in which S=1, D/hc=±0.0990±0.0005 cm−1, E/hc=±0.0043±0.0007 cm−1, and g ...
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[The enhancing effect of borneol on the absorption of tetramethylpyrazine].

Yao xue xue bao = Acta pharmaceutica Sinica, 2012
To explore the mechanism of the absorption enhancement of borneol, the effect of borneol on the intestinal absorption and the pharmacokinetics of tetramethylpyrazine phosphate after oral administration were investigated. In situ intestinal recirculation was performed to study the effect of various concentrations of borneol on the absorption of ...
Yan-yu, Xiao, Zhi-peng, Chen, Qi-neng, Ping, Hong-xuan, Chen   +3 more
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[Enhancement of absorption of tetramethylpyrazine by synthetic borneol].

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990
Sprague-Dawley rats were given ig tetramethylpyrazine phosphate (TMP) 5 mg/kg with or without previous borneol 5 mg/kg. The plasma TMP concentrations were analysed by GC method, and the data were treated by NONLIN program. The Cmax were 931 and 562 ng/ml, respectively, (P less than 0.01); while the AUC were 68,849 and 37,174, respectively, (P less than
T F, Chen, S G, Lin, L X, Chen, G F, Jiang, Z Y, Liang, M, Yang, Y Z, Qian, Y A, Xie   +7 more
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[Studies on the metabolites of tetramethylpyrazine in human urine].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1998
Tetramethylpyrazine (TMP), an active ingredient in Chuanxiong (Ligusticum Wallich Franch), a traditional Chinese herb, has been widely used especially in the treatment of patients with cerebral ischemic diseases in China. TMP was reported to have a short half-life time because of its rapid metabolism in the liver.
Y, Ye, S, Wang, J, Jiang
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