Results 181 to 190 of about 5,031 (222)

Antithrombotic Effects of Tetramethylpyrazine in In Vivo Experiments

International Journal of Hematology, 2001
In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1.5-fold compared with normal saline ...
J R, Sheu, G, Hsiao, Y M, Lee, M H, Yen
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Paramagnetic resonance of phosphorescent tetramethylpyrazine

Molecular Physics, 1975
Electron paramagnetic resonance spectra have been obtained of tetramethylpyrazine in its lowest (ππ*) triplet state in several rigid matrices. Some unusual observations were made : 1. (1) In a durene crystal host the in-plane zero-field principal axes are not parallel to the molecular symmetry axes. 2.
M.S. de Groot, I.A.M. Hesselmann, F.J. Reinders, J.H. van der Waals   +3 more
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Physicochemical characterization and percutaneous delivery of 2,3,5,6-tetramethylpyrazine

International Journal of Pharmaceutics, 2003
The objective of this work is to investigate the percutaneous permeability of 2,3,5,6-tetramethylpyrazine (TMP), an active ingredient originally isolated from Ligusticum wallichii Franch. Certain physicochemical properties of TMP, including its partition coefficient and pH-solubility profile, were studied.
Xiaohong, Qi, Chrisita, Ackermann, Duxin, Sun, Minli, Sheng, Huimin, Hou   +4 more
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A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

Journal of Molecular Neuroscience, 2015
Neurodegenerative disorders are one of the leading causes of death among the elderly. Therapeutic approaches with a single target have proven unsuccessful in treating these diseases. Structural combination of multi-functional compounds may lead to a molecule with multiple properties.
Chen, Hai-Yun, Xu, Da-Ping, Tan, Guo-Lian, Cai, Wei, Zhang, Gao-Xiao, Cui, Wei, Wang, Jin-Zhao, Long, Cheng, Sun, Ye-Wei, Yu, Pei, Tsim, Karl Wahkeung, Zhang, Zai-Jun, Han, Yi-Fan, Wang, Yu-Qiang   +13 more
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Pharmacokinetics of a New Tetramethylpyrazine Analogue CXC195 in Rats

Drug Research, 2013
To investigate the pharmacokinetical characteristics of a new neuroprotective drug CXC195 after intraperitoneal injection in rats.A single 10 mg · kg-1 of CXC195 was intraperitoneally injected to 8 rats after fasting overnight, respectively. 500 microliters of blood samples were collected at scheduled time before and after administration.
C, Wei, L, Kong, X, Wei, L, Chen, X, Liu, X, Zhang, X, Liu, H, Liu   +7 more
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The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes

Journal of Ethnopharmacology, 2010
Ligusticum wallichi Franchat (chuanxiong) is a very common traditional Chinese herbal medicine in China. Tetramethylpyrazine (TMP) is a major active ingredient extracted from Ligusticum wallichi Franchat. We investigated the protective effect of TMP on interleukin-1β (IL-1β) induced proteoglycan (PG) degradation and apoptosis in rabbit articular ...
Xiao-dong, Ju, Min, Deng, Ying-fang, Ao, Chang-long, Yu, Jian-quan, Wang, Jia-kuo, Yu, Guo-qing, Cui, Yue-lin, Hu   +7 more
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Blockade of Adrenergic and Cholinergic Transmissions by Tetramethylpyrazine

Planta Medica, 1981
The pharmacological actions of an amide alkaloid, tetramethylpyrazine (TMPZ), isolated from the stem of JATROPHA PODAGRICA H OOK (Euphorbiaceae) have been investigated on the electrically-evoked contractions, relaxations and twitches of some cholinergically- and adrenergically-innervated muscle preparations IN VITRO and IN VIVO.
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Tetramethylpyrazine reduces ischemic brain injury in rats

Neuroscience Letters, 2004
Tetramethylpyrazine (TMP), which is widely used in the treatment of ischemic stroke by Chinese herbalists, is one of the most important active ingredients of the traditional Chinese herbal medicine, Ligusticum wallichii Franchat (Chung Xiong). However, the mechanism by which TMP protects the brain is still not clear. We examined neuroprotective effects
Su-Lan, Liao, Tsung-Kuei, Kao, Wen-Yin, Chen, Yu-Sheng, Lin, Shih-Yun, Chen, Shue-Ling, Raung, Ching-Wen, Wu, Hsi-Chi, Lu, Chun-Jung, Chen   +8 more
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Coronary and Systemic Hemodynamic Effects of Tetramethylpyrazine in the Dog

Journal of Cardiovascular Pharmacology, 1985
The hemodynamic effects of tetramethylpyrazine were examined in 27 anesthetized open chest dogs with electromagnetic flowmeter probes on the left circumflex coronary artery and ascending aorta. Tetramethylpyrazine, 2-15 mg/kg i.v., caused prominent systemic and coronary vasodilation, with a maximum reduction of mean aortic pressure from 92 +/- 5 mm Hg ...
X Z, Dai, R J, Bache
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Tetramethylpyrazine in Vinegar: A Bibliometric Analysis and Synthetic Mechanism

Journal of Food Science
ABSTRACT Vinegar is widely recognized for its distinctive flavor, nutritional value, and numerous health benefits, which are particularly attributed to the presence of tetramethylpyrazine (TMP). TMP not only contributes to the aroma of vinegar but also exhibits significant anti‐inflammatory, antioxidant, and cardioprotective effects ...
Linfeng Xie, Yiwen Xiao, Ya Wang, Jiantao Liu, Boliang Gao, Bin Liu, Du Zhu   +6 more
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