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The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes
Journal of Ethnopharmacology, 2010Ligusticum wallichi Franchat (chuanxiong) is a very common traditional Chinese herbal medicine in China. Tetramethylpyrazine (TMP) is a major active ingredient extracted from Ligusticum wallichi Franchat. We investigated the protective effect of TMP on interleukin-1β (IL-1β) induced proteoglycan (PG) degradation and apoptosis in rabbit articular ...
Xiao-dong, Ju +7 more
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Blockade of Adrenergic and Cholinergic Transmissions by Tetramethylpyrazine
Planta Medica, 1981The pharmacological actions of an amide alkaloid, tetramethylpyrazine (TMPZ), isolated from the stem of JATROPHA PODAGRICA H OOK (Euphorbiaceae) have been investigated on the electrically-evoked contractions, relaxations and twitches of some cholinergically- and adrenergically-innervated muscle preparations IN VITRO and IN VIVO.
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Coronary and Systemic Hemodynamic Effects of Tetramethylpyrazine in the Dog
Journal of Cardiovascular Pharmacology, 1985The hemodynamic effects of tetramethylpyrazine were examined in 27 anesthetized open chest dogs with electromagnetic flowmeter probes on the left circumflex coronary artery and ascending aorta. Tetramethylpyrazine, 2-15 mg/kg i.v., caused prominent systemic and coronary vasodilation, with a maximum reduction of mean aortic pressure from 92 +/- 5 mm Hg ...
X Z, Dai, R J, Bache
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Tetramethylpyrazine in Vinegar: A Bibliometric Analysis and Synthetic Mechanism
Journal of Food ScienceABSTRACT Vinegar is widely recognized for its distinctive flavor, nutritional value, and numerous health benefits, which are particularly attributed to the presence of tetramethylpyrazine (TMP). TMP not only contributes to the aroma of vinegar but also exhibits significant anti‐inflammatory, antioxidant, and cardioprotective effects ...
Linfeng Xie +6 more
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Inhibition of Vasoconstriction by Tetramethylpyrazine
Journal of Cardiovascular Pharmacology, 1990Using dog mesenteric arterial ring preparations, we studied the in vitro vascular effects of tetramethylpyrazine (TMP, also known as Ligustrazine), a vasoactive component derived from Ligustium Wollichii Franchat; a widely used ingredient in Chinese herbal medicine for the treatment of cardiovascular diseases.
C Y, Kwan, E E, Daniel, M C, Chen
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Effect of Tetramethylpyrazine on Reserpine-Induced Gastric Lesion in Rats
Digestive Diseases and Sciences, 1998The present study was undertaken to determine the effect of tetramethylpyrazine administered intraperitoneally on gastric lesions, gastric acid secretion, gastric barrier mucus secretion, and gastric contraction in reserpine-treated rats. The results of this study demonstrated that tetramethylpyrazine at doses of 0.5, 1, 10, and 20 mg/kg significantly ...
J L, Wan, C L, Wang, Q D, Chang
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[Studies on the metabolites of tetramethylpyrazine in rabbits].
Yao xue xue bao = Acta pharmaceutica Sinica, 1998The metabolites of tetramethylpyrazine (TMPz) in rabbit have been separated by HPLC and solvent extraction. Their structures were identified by means of UV, IR, MS and NMR spectroscopy. The possible metabolic ways of TMPz are oxidzation of one of the four methyl groups to hydroxymethyl and carboxyl group forming 2-hydroxymethyl-3, 5, 6 ...
X, Chen, S N, Dong
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[Protective mechanism of tetramethylpyrazine on cardiovascular system].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023Tetramethylpyrazine is the main component of Ligusticum chuanxiong. Studies have found that tetramethylpyrazine has a good protective effect against cardiovascular diseases. In the heart, tetramethylpyrazine can reduce myocardial ischemia/reperfusion injury by inhibiting oxidative stress, regulating autophagy, and inhibiting cardiomyocyte apoptosis ...
Chun-Kun, Yang +6 more
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Effects of Tetramethylpyrazine on Isolated Atria of the Guinea-Pig
Planta Medica, 1981The chronotropic and inotropic effects of tetramethylpyrazine (TMPZ) obtained from the stem of JATROPHA PODAGRICA H OOK (Euphorbiaceae) have been investigated on guinea-pig isolated atria. TMPZ caused negative chronotropic and inotropic responses on the isolated atria of guinea-pigs.
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Paramagnetic Resonance of the Triplet State of Tetramethylpyrazine
The Journal of Chemical Physics, 1967EPR measurements are reported for solid solutions of tetramethylpyrazine (TMP) in durene under ultraviolet irradiation at 77°K. The fine structure of the paramagnetic resonance spectrum observed at 9.2 and 35 GHz may be described by the spin Hamiltonian H=gβH·S+DSz2+E(Sx2−Sy2) in which S=1, D/hc=±0.0990±0.0005 cm−1, E/hc=±0.0043±0.0007 cm−1, and g ...
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