Results 171 to 180 of about 3,627 (215)

Tetramethylpyrazine reduces ischemic brain injury in rats

Neuroscience Letters, 2004
Tetramethylpyrazine (TMP), which is widely used in the treatment of ischemic stroke by Chinese herbalists, is one of the most important active ingredients of the traditional Chinese herbal medicine, Ligusticum wallichii Franchat (Chung Xiong). However, the mechanism by which TMP protects the brain is still not clear. We examined neuroprotective effects
Su-Lan, Liao, Tsung-Kuei, Kao, Wen-Yin, Chen, Yu-Sheng, Lin, Shih-Yun, Chen, Shue-Ling, Raung, Ching-Wen, Wu, Hsi-Chi, Lu, Chun-Jung, Chen   +8 more
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Antiplatelet activity of tetramethylpyrazine

Thrombosis Research, 1994
Tetramethylpyrazine (TMPZ) is an active ingredient of a Chinese herbal medicine. We have previously shown that TMPZ possesses antithrombotic activity in rat thrombotic models. Inhibition of platelet aggregation and promotion of disaggregation contributed to the antithrombotic activity of TMPZ.
S Y, Liu, D M, Sylvester
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Antithrombotic/antiplatelet activity of tetramethylpyrazine

Thrombosis Research, 1990
Tetramethylpyrazine (TMPZ) is an active component that can be extracted from certain plants. In China, this herbal extract is used to treat ischemic vascular diseases. We have assessed the antithrombotic activity of TMPZ using arterial and venous thrombosis models in rats.
S Y, Liu, D M, Sylvester
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Tetramethylpyrazine : a Bacillus subtilis Growth Factor

Nature, 1962
WE have found1 that a strain of Bacillus sublilis produced tetramethylpyrazine in synthesized media containing asparagine as nitrogen source.
T, KOSUGE, H, KAMIYA
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Tetramethylpyrazine in the Treatment of Cardiovascular and Cerebrovascular Diseases

Planta Medica, 1983
Chen Ke-Ji
exaly   +4 more sources

Antiplatelet structure-activity relationship of tetramethylpyrazine

Life Sciences, 1994
Tetramethylpyrazine (TMPZ) is an active component of certain plants previously found to have inhibitory effects on platelet function using both in vivo and in vitro assays(1). In this study, we examined the antiplatelet activity of structural analogues of TMPZ in order to assess structural requirements for activity.
S Y, Liu, D M, Sylvester
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Antithrombotic Effects of Tetramethylpyrazine in In Vivo Experiments

International Journal of Hematology, 2001
In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1.5-fold compared with normal saline ...
J R, Sheu, G, Hsiao, Y M, Lee, M H, Yen
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Paramagnetic resonance of phosphorescent tetramethylpyrazine

Molecular Physics, 1975
Electron paramagnetic resonance spectra have been obtained of tetramethylpyrazine in its lowest (ππ*) triplet state in several rigid matrices. Some unusual observations were made : 1. (1) In a durene crystal host the in-plane zero-field principal axes are not parallel to the molecular symmetry axes. 2.
M.S. de Groot, I.A.M. Hesselmann, F.J. Reinders, J.H. van der Waals   +3 more
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Physicochemical characterization and percutaneous delivery of 2,3,5,6-tetramethylpyrazine

International Journal of Pharmaceutics, 2003
The objective of this work is to investigate the percutaneous permeability of 2,3,5,6-tetramethylpyrazine (TMP), an active ingredient originally isolated from Ligusticum wallichii Franch. Certain physicochemical properties of TMP, including its partition coefficient and pH-solubility profile, were studied.
Xiaohong, Qi, Chrisita, Ackermann, Duxin, Sun, Minli, Sheng, Huimin, Hou   +4 more
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Pharmacokinetics of a New Tetramethylpyrazine Analogue CXC195 in Rats

Drug Research, 2013
To investigate the pharmacokinetical characteristics of a new neuroprotective drug CXC195 after intraperitoneal injection in rats.A single 10 mg · kg-1 of CXC195 was intraperitoneally injected to 8 rats after fasting overnight, respectively. 500 microliters of blood samples were collected at scheduled time before and after administration.
C, Wei, L, Kong, X, Wei, L, Chen, X, Liu, X, Zhang, X, Liu, H, Liu   +7 more
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