Results 1 to 10 of about 5,026 (197)
Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure [PDF]
BMC Cell Biology, 2005 Background Mammalian cells have been reported to have a p53-dependent tetraploidy checkpoint that blocks cell cycle progression in G1 in response to failure of cell division.
Stearns Tim, Wong Connie
doaj +2 more sources
Rare case of myelodysplastic syndrome with near-tetraploidy and TP53 mutation [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2023 Introduction. Chromosomal numerical aberrations are very common in hematological malignancies, but near-tetraploidy (80–104 chromosomes) is rare in myeloid lineage malignancies, with only a few cases reported in myelodysplastic syndrome (MDS).
Čolović Nataša +4 more
doaj +3 more sources
Challenging diagnoses of tetraploidy/diploidy and trisomy 12: utility of first-tier prenatal testing methods [PDF]
Frontiers in Genetics, 2023 Introduction: Chromosome mosaicism and low-grade mosaicism present a challenge for diagnosis in the era of SNP array and NGS. Tetraploidy is a rare numerical chromosomal abnormality characterized by the presence of four copies of each chromosome.
Irina Ioana Iordanescu +11 more
doaj +2 more sources
Induction to tetraploidy in Pacific oysters (Crassostrea gigas)
Acta Scientiarum: Animal Sciences, 2022 As an alternative to the use of cytochalasin B (CB), 6-dimethylamino-purine (6-DMAP) and thermal shock (heat shock by increasing the temperature from 25 to 36ºC) could be used to induce tetraploidy in Pacific oyster (Crassostrea gigas) diploids ...
Emílio Mateus Costa Melo +3 more
doaj +3 more sources
Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells
Molecular Oncology, 2023 Tetraploidy is a hallmark of cancer cells, and tetraploidy‐selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti‐proliferative ...
Koya Yoshizawa +14 more
doaj +2 more sources
Tetraploidy in hydatidiform moles [PDF]
Human Reproduction, 2013 How does tetraploidy develop in hydatidiform moles (HMs), and what is the frequency of the different origins?Most molar pregnancies with tetraploid cells appear to be produced by somatic endoreduplications, while a minority originate from a tetraploid zygote.
Linda Sundvall +5 more
openalex +3 more sources
REVERSIBLE TETRAPLOIDY AS AN EVOLUTIONARY MECHANISM [PDF]
Evolution, 1971 Polyploidization is reversible. Randolph and Fischer (1939) obtained diploid offspring from autotetraploid maize. Several fertile haploids have also been obtained from successful tetraploid and octaploid species (Kimber and Riley, 1963; de Wet and Harlan, 1970), and Raven and Thompson (1964) pointed out that there is no experimental basis or ...
J. M. J. de Wet
openalex +3 more sources
Tetraploidy and tumor development [PDF]
Cancer Cell, 2005 In tumorigenesis, aneuploidy is frequently preceded by tetraploidy. Major issues include how tetraploidy arises and how cells can effectively respond to this state. Two recent papers address these issues. Shi and King demonstrate that nondisjunction of chromosomes in mitosis frequently results in tetraploidy through mitotic cleavage failure.
Robert L. Margolis
openalex +3 more sources
Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192 [PDF]
HGG AdvancesSummary: In this study, we report on mosaic variegated aneuploidy (MVA) syndrome with tetraploidy and predisposition to infertility in a family. Sequencing analysis identified that the CEP192 biallelic variants (c.1912C>T, p.His638Tyr and c.5750A>G, p ...
Jihong Guo +21 more
doaj +2 more sources
Discovery of tetraploidy in a mammal [PDF]
Nature, 1999 The red viscacha rat is unaffected by having double the usual number of chromosomes. Polyploidy, or having more than a pair of each type of chromosome, is considered to be unlikely in mammals because it would disrupt the mechanism of dosage compensation that normally inactivates one X chromosome in females1.
Milton H. Gallardo +4 more
openalex +3 more sources