Results 21 to 30 of about 4,590 (177)
Addressing a weakness of anticancer therapy with mitosis inhibitors: Mitotic slippage
Molecular & Cellular Oncology, 2017 Mitosis inhibitors, which include antimicrotubule drugs, are chemotherapy agents that induce the arrest and apoptosis of mitotic cells. Mitotic slippage, in which mitotically arrested cells exit mitosis, limits the effectiveness of mitosis inhibitors. We
Riju S. Balachandran, Edward T. Kipreos
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Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells
eLife, 2020 Tetraploidy has long been of interest to both cell and cancer biologists, partly because of its documented role in tumorigenesis. A common model proposes that the extra centrosomes that are typically acquired during tetraploidization are responsible for ...
Nicolaas C Baudoin +5 more
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Journal of Developmental Biology, 2023 Whole genome duplication (WGD) or polyploidization can occur at the cellular, tissue, and organismal levels. At the cellular level, tetraploidization has been proposed as a driver of aneuploidy and genome instability and correlates strongly with cancer ...
Mara Schvarzstein +3 more
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Tetraploidy and CIN: a dangerous combination [PDF]
Cell Cycle, 2015 Chromosomal instability (CIN) is a hallmark of cancer, and is associated with both poor prognosis and drug resistance.1 Tetraploidy has also been frequently observed in human cancer despite being a...
Sally, Dewhurst, Charles, Swanton
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100 Years of Chromosome Research in Rye, Secale L.
Plants, 2022 Although microscopy and genetics were still in their infancy, there are cytological results produced a hundred years ago that are still relevant today. Since the 1920s, rye has been a subject of chromosome research. It started by plotting its mitotic and
Rolf Schlegel
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Journal of Biological Researches, 2012 The aim of this study were to know growth and gonadal development of tetraploidy common carp. The method that used in this study was experiment. Treatment that used was tetraploidyzation by heat shock 40 °C during 1.5 minutes of common carp eggs to 29 ...
Akhmad Taufiq Mukti
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Comparative cytogenetics of anembryonic pregnancies and missed abortions in human
Вавиловский журнал генетики и селекции, 2023 Miscarriage is an important problem in human reproduction, affecting 10–15 % of clinically recognized pregnancies. The cases of embryonic death can be divided into missed abortion (MA), for which the ultrasound sign of the embryo death is the absence of ...
T. V. Nikitina +5 more
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Morphological changes in colchicine--treated Pelargonium × hortorum L.H. Bailey greenhouse plants
Horticultural Science, 2010 Polyploids were effectively pre-selected in colchicine-treated plants of the desirable brown-leaved cultivar Black Velvet Scarlet F1 of the species Pelargonium × hortorum L.H.
P. Jadrná, O. Plavcová, F. Kobza
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Artificial induction of tetraploidy in Humulus lupulus L. using oryzalin
Acta Agrobotanica, 2019 The aim of the research was to establish an efficient procedure for in vitro micropropagation in order to obtain numbers of identical plants for in vitro polyploidization of Humulus lupulus (2n = 20), using antimicrotubule agent oryzalin.
Michaela Švécarová +3 more
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Reversible Tetraploidy as an Evolutionary Mechanism [PDF]
Evolution, 1971 Polyploidization is reversible. Randolph and Fischer (1939) obtained diploid offspring from autotetraploid maize. Several fertile haploids have also been obtained from successful tetraploid and octaploid species (Kimber and Riley, 1963; de Wet and Harlan, 1970), and Raven and Thompson (1964) pointed out that there is no experimental basis or ...
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