Results 1 to 10 of about 4,521 (115)

Challenging diagnoses of tetraploidy/diploidy and trisomy 12: utility of first-tier prenatal testing methods [PDF]

Frontiers in Genetics, 2023
Introduction: Chromosome mosaicism and low-grade mosaicism present a challenge for diagnosis in the era of SNP array and NGS. Tetraploidy is a rare numerical chromosomal abnormality characterized by the presence of four copies of each chromosome.
Irina Ioana Iordanescu, Irina Ioana Iordanescu, Anca Teodora Neacsu, Andreea Catana, Andreea Catana, Zina Barabas-CuzmicI, Viorel Suciu, Cristina Dragomir, Diana Elena Voicu, Emilia Severin, Mariela Sanda Militaru, Mariela Sanda Militaru   +11 more
doaj   +2 more sources

Tetraploidy in normal tissues and diseases: mechanisms and consequences [PDF]

Chromosoma
Miroslav Misik, Fenech M, Fenech Michael   +2 more
exaly   +2 more sources

Rare case of myelodysplastic syndrome with near-tetraploidy and TP53 mutation [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2023
Introduction. Chromosomal numerical aberrations are very common in hematological malignancies, but near-tetraploidy (80–104 chromosomes) is rare in myeloid lineage malignancies, with only a few cases reported in myelodysplastic syndrome (MDS).
Čolović Nataša, Đorđević Vesna, Radojković Milica, Karan-Đurašević Teodora, Tošić Nataša   +4 more
doaj   +1 more source

Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells

Molecular Oncology, 2023
Tetraploidy is a hallmark of cancer cells, and tetraploidy‐selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti‐proliferative ...
Koya Yoshizawa, Akira Matsura, Masaya Shimada, Sumire Ishida‐Ishihara, Fuyu Sato, Takahiro Yamamoto, Kan Yaguchi, Eiji Kawamoto, Taruho Kuroda, Kazuya Matsuo, Nobuyuki Tamaoki, Ryuichi Sakai, Yasuhito Shimada, Mithilesh Mishra, Ryota Uehara   +14 more
doaj   +1 more source

Spindle Architectural Features Must Be Considered Along With Cell Size to Explain the Timing of Mitotic Checkpoint Silencing

Frontiers in Physiology, 2021
Mitosis proceeds through a defined series of events that is largely conserved, but the amount of time needed for their completion can vary in different cells and organisms.
Mathew Bloomfield, Jing Chen, Daniela Cimini   +2 more
doaj   +1 more source

Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance

Cells, 2020
The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life.
Roberta Fraschini
doaj   +1 more source

Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib

Blood Advances, 2017
: Ibrutinib is a highly effective targeted therapy for chronic lymphocytic leukemia (CLL). However, ibrutinib must be discontinued in a subset of patients due to progressive CLL or transformation to aggressive lymphoma (Richter transformation ...
Cecelia R. Miller, Amy S. Ruppert, Nyla A. Heerema, Kami J. Maddocks, Jadwiga Labanowska, Heather Breidenbach, Gerard Lozanski, Weiqiang Zhao, Amber L. Gordon, Jeffrey A. Jones, Joseph M. Flynn, Samantha M. Jaglowski, Leslie A. Andritsos, Kristie A. Blum, Farrukh T. Awan, Kerry A. Rogers, Michael R. Grever, Amy J. Johnson, Lynne V. Abruzzo, Erin K. Hertlein, James S. Blachly, Jennifer A. Woyach, John C. Byrd   +22 more
doaj   +1 more source

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

BMC Cell Biology, 2005
Background Mammalian cells have been reported to have a p53-dependent tetraploidy checkpoint that blocks cell cycle progression in G1 in response to failure of cell division.
Stearns Tim, Wong Connie
doaj   +1 more source

Artificial Autotetraploidy Induction Possibility of Two Iranian Endemic Mint (<i>Mentha mozaffarianii</i>) Ecotypes

Notulae Scientia Biologicae, 2014
The present study was conducted to polyploidy possibility induction of two Iranian endemic mint (Mentha mozaffarianii) ecotypes. For this purpose, three experiments were done. The first experiment was factorial, based on completely randomized design with
Askar GHANI, Seyyed Hossein NEAMATI, Majid AZIZI, Mohammad Jamal SAHARKHIZ, Mohammad FARSI   +4 more
doaj   +3 more sources

Induction of Polyploidy in Citrus Rootstocks through In Vitro Colchicine Treatment of Seed-Derived Explants

Agronomy, 2023
Polyploidy, frequently observed in citrus species, aids in achieving better adaptation to environmental stresses. In this context, the current work aims to develop stable tetraploids in citrus rootstock cultivars, viz., Rough lemon, Rangpur lime and ...
Vijayakumari Narukulla, Yogesh Lahane, Krutika Fiske, Shashi Pandey, Vasileios Ziogas   +4 more
doaj   +1 more source