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Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure [PDF]
BMC Cell Biology, 2005 Background Mammalian cells have been reported to have a p53-dependent tetraploidy checkpoint that blocks cell cycle progression in G1 in response to failure of cell division.
Stearns Tim, Wong Connie
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Evidence for degenerate tetraploidy in bdelloid rotifers [PDF]
Proceedings of the National Academy of Sciences, 2008 Rotifers of class Bdelloidea have evolved for millions of years apparently without sexual reproduction. We have sequenced 45- to 70-kb regions surrounding the four copies of the hsp82 gene of the bdelloid rotifer Philodina roseola , each of which is on a separate chromosome.
Jessica L. Mark Welch +3 more
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Degenerate Tetraploidy Was Established Before Bdelloid Rotifer Families Diverged [PDF]
, 2008 Rotifers of Class Bdelloidea are abundant freshwater invertebrates known for their remarkable ability to survive desiccation and their lack of males and meiosis.
Jang-Hyun Hur +3 more
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Rare case of myelodysplastic syndrome with near-tetraploidy and TP53 mutation [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2023 Introduction. Chromosomal numerical aberrations are very common in hematological malignancies, but near-tetraploidy (80–104 chromosomes) is rare in myeloid lineage malignancies, with only a few cases reported in myelodysplastic syndrome (MDS).
Čolović Nataša +4 more
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Frontiers in Genetics, 2023 Introduction: Chromosome mosaicism and low-grade mosaicism present a challenge for diagnosis in the era of SNP array and NGS. Tetraploidy is a rare numerical chromosomal abnormality characterized by the presence of four copies of each chromosome.
Irina Ioana Iordanescu +11 more
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Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells
Molecular Oncology, 2023 Tetraploidy is a hallmark of cancer cells, and tetraploidy‐selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti‐proliferative ...
Koya Yoshizawa +14 more
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Frontiers in Physiology, 2021 Mitosis proceeds through a defined series of events that is largely conserved, but the amount of time needed for their completion can vary in different cells and organisms.
Mathew Bloomfield +2 more
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The consequences of tetraploidy and aneuploidy [PDF]
Journal of Cell Science, 2008 Polyploidy, an increased number of chromosome sets, is a surprisingly common phenomenon in nature, particularly in plants and fungi. In humans, polyploidy often occurs in specific tissues as part of terminal differentiation. Changes in ploidy can also result from pathophysiological events that are caused by viral-induced cell fusion or erroneous cell ...
Zuzana Storchova, Christian Kuffer
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Discovery of tetraploidy in a mammal [PDF]
Nature, 1999 The red viscacha rat is unaffected by having double the usual number of chromosomes. Polyploidy, or having more than a pair of each type of chromosome, is considered to be unlikely in mammals because it would disrupt the mechanism of dosage compensation that normally inactivates one X chromosome in females1.
Rodney L. Honeycutt +4 more
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