Results 11 to 20 of about 9,531 (204)

Challenging diagnoses of tetraploidy/diploidy and trisomy 12: utility of first-tier prenatal testing methods [PDF]

Frontiers in Genetics, 2023
Introduction: Chromosome mosaicism and low-grade mosaicism present a challenge for diagnosis in the era of SNP array and NGS. Tetraploidy is a rare numerical chromosomal abnormality characterized by the presence of four copies of each chromosome.
Irina Ioana Iordanescu, Irina Ioana Iordanescu, Anca Teodora Neacsu, Andreea Catana, Andreea Catana, Zina Barabas-CuzmicI, Viorel Suciu, Cristina Dragomir, Diana Elena Voicu, Emilia Severin, Mariela Sanda Militaru, Mariela Sanda Militaru   +11 more
doaj   +2 more sources

Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192 [PDF]

HGG Advances
Summary: In this study, we report on mosaic variegated aneuploidy (MVA) syndrome with tetraploidy and predisposition to infertility in a family. Sequencing analysis identified that the CEP192 biallelic variants (c.1912C>T, p.His638Tyr and c.5750A>G, p ...
Jihong Guo, Wen-Bin He, Lei Dai, Fen Tian, Zhenqing Luo, Fang Shen, Ming Tu, Yu Zheng, Liu Zhao, Chen Tan, Yongteng Guo, Lan-Lan Meng, Wei Liu, Mei Deng, Xinghan Wu, Yu Peng, Shuju Zhang, Guang-Xiu Lu, Ge Lin, Hua Wang, Yue-Qiu Tan, Yongjia Yang   +21 more
doaj   +2 more sources

Polyploidy is widespread in Microsporidia [PDF]

Microbiology Spectrum
Microsporidia are obligate intracellular eukaryotic parasites with an extremely broad host range. They have both economic and public health importance.
Amjad Khalaf, Mara K. N. Lawniczak, Mark L. Blaxter, Kamil S. Jaron   +3 more
doaj   +2 more sources

Rare case of myelodysplastic syndrome with near-tetraploidy and TP53 mutation [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2023
Introduction. Chromosomal numerical aberrations are very common in hematological malignancies, but near-tetraploidy (80–104 chromosomes) is rare in myeloid lineage malignancies, with only a few cases reported in myelodysplastic syndrome (MDS).
Čolović Nataša, Đorđević Vesna, Radojković Milica, Karan-Đurašević Teodora, Tošić Nataša   +4 more
doaj   +1 more source

The frequency and importance of polyploidy in tropical rainforest tree radiations. [PDF]

New Phytol
Summary The presence of more than two copies of the genome in an organism, termed ‘polyploidy’, is a crucial force in plant evolution, generating genetic, phenotypic and ecological diversity. [Correction added on 22 January 2026, after first online publication: the preceding sentence has been corrected.] The Amazonian tree flora is the most species ...
Schley RJ, Piñeiro R, Nicholls JA, Gaynor ML, Lewis GP, Fonseca Pezzini F, Dexter KG, Kidner C, Pennington RT, Twyford AD.   +9 more
europepmc   +3 more sources

Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells

Molecular Oncology, 2023
Tetraploidy is a hallmark of cancer cells, and tetraploidy‐selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti‐proliferative ...
Koya Yoshizawa, Akira Matsura, Masaya Shimada, Sumire Ishida‐Ishihara, Fuyu Sato, Takahiro Yamamoto, Kan Yaguchi, Eiji Kawamoto, Taruho Kuroda, Kazuya Matsuo, Nobuyuki Tamaoki, Ryuichi Sakai, Yasuhito Shimada, Mithilesh Mishra, Ryota Uehara   +14 more
doaj   +1 more source

Tetraploidy in hydatidiform moles [PDF]

Human Reproduction, 2013
How does tetraploidy develop in hydatidiform moles (HMs), and what is the frequency of the different origins?Most molar pregnancies with tetraploid cells appear to be produced by somatic endoreduplications, while a minority originate from a tetraploid zygote.
Sundvall Germeys, Linda Karin M, Lund, Helle, Niemann, Isa, Jensen, Uffe Birk, Bolund, Lars, Sunde, Lone   +5 more
openaire   +2 more sources

Clinicopathological analysis of near-tetraploidy/tetraploidy acute myeloid leukaemia [PDF]

Journal of Clinical Pathology, 2015
Aims Near-tetraploidy/tetraploidy (NT/T) is a rare cytogenetic alteration in acute myeloid leukaemia (AML). NT/T-AML is categorised as complex cytogenetics and therefore, presumed to have an unfavourable prognosis. Our aim is to further characterise the clinical, morphological, cytogenetic and prognostic features of
Changlee S, Pang, Mark J, Pettenati, Timothy S, Pardee   +2 more
openaire   +2 more sources

Spindle Architectural Features Must Be Considered Along With Cell Size to Explain the Timing of Mitotic Checkpoint Silencing

Frontiers in Physiology, 2021
Mitosis proceeds through a defined series of events that is largely conserved, but the amount of time needed for their completion can vary in different cells and organisms.
Mathew Bloomfield, Jing Chen, Daniela Cimini   +2 more
doaj   +1 more source

Development of tetraploidy in salmonids

Genetics Selection Evolution, 1980
Refstie T
doaj   +4 more sources