Results 31 to 40 of about 9,531 (204)
Phylogeny and evolutionary history of glycogen synthase kinase 3/SHAGGY-like kinase genes in land plants [PDF]
, 2013 Background: GSK3 (glycogen synthase kinase 3) genes encode signal transduction proteins with roles in a variety of biological processes in eukaryotes.
André S Chanderbali +4 more
core +2 more sources
Induction to tetraploidy in Pacific oysters (Crassostrea gigas)
Acta Scientiarum: Animal Sciences, 2022 As an alternative to the use of cytochalasin B (CB), 6-dimethylamino-purine (6-DMAP) and thermal shock (heat shock by increasing the temperature from 25 to 36ºC) could be used to induce tetraploidy in Pacific oyster (Crassostrea gigas) diploids ...
Emílio Mateus Costa Melo +3 more
doaj +1 more source
Molecular biomarkers and ablative therapies for Barrett’s esophagus [PDF]
, 2012 Author version made available in accordance with the publisher's policy.Barrett’s esophagus is the major risk factor for esophageal adenocarcinoma. Endoscopic interventions which ablate Barrett’s esophagus mucosa lead to replacement with a new squamous ...
Chisolm, Jacob A +3 more
core +1 more source
Tetraploidy and tumor development [PDF]
Cancer Cell, 2005 In tumorigenesis, aneuploidy is frequently preceded by tetraploidy. Major issues include how tetraploidy arises and how cells can effectively respond to this state. Two recent papers address these issues. Shi and King demonstrate that nondisjunction of chromosomes in mitosis frequently results in tetraploidy through mitotic cleavage failure.
openaire +2 more sources
Tetraploidy causes chromosomal instability in acentriolar mouse embryos
Nature Communications, 2019 During cell division, tetraploidy can drive chromosomal instability (CIN) via supernumerary centrosomes, but it is unclear if this is the only route to CIN. Here the authors show that, in early mouse embryos, tetraploidy can drive chromosomal instability
Lia Mara Gomes Paim, Greg FitzHarris
doaj +1 more source
Intratumoral patterns of clonal evolution in gliomas [PDF]
, 2009 Few studies have explored the patterns of clonal evolution in gliomas. Here, we investigate the cytogenetic patterns of intratumoral clonal evolution of gliomas and their impact on tumor histopathology and patient survival.
Crespo, I +7 more
core +1 more source
Tetraploidy and tumor development
Oncotarget, 2014 Tetraploid cells, which contain a doubled chromosomal content, are known to facilitate tumorigenesis [1]. Two specific characteristics of tetraploid cells play major roles in promoting neoplastic transformation. First, proliferating tetraploid cells are genomically unstable and accumulate both numerical and structural chromosomal abnormalities.
Sanghee, Lim, Neil J, Ganem
openaire +2 more sources
Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells
eLife, 2020 Tetraploidy has long been of interest to both cell and cancer biologists, partly because of its documented role in tumorigenesis. A common model proposes that the extra centrosomes that are typically acquired during tetraploidization are responsible for ...
Nicolaas C Baudoin +5 more
doaj +1 more source
Antioxidant defenses during early developmental stages in tetraploid rainbow trout, Oncorhynchus mykiss [PDF]
Caspian Journal of Environmental Sciences, 2023 Antioxidant defense status was examined during early developmental stages of rainbow trout, Oncorhynchus mykiss, as affected by heat shock (HS) treatment to induce tetraploidy.
Hajar Sadat Tabatabaei Pozveh +4 more
doaj +1 more source
The fate of extra centrosomes in newly formed tetraploid cells: should I stay, or should I go?
Frontiers in Cell and Developmental Biology, 2023 An increase in centrosome number is commonly observed in cancer cells, but the role centrosome amplification plays along with how and when it occurs during cancer development is unclear. One mechanism for generating cancer cells with extra centrosomes is
Mathew Bloomfield, Daniela Cimini
doaj +1 more source