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Journal of Chemical Information and Modeling, 2012
Bioisosterism involving replacement of a carboxylic acid substituent by 1H-tetrazole, yielding deprotonated carboxylate and tetrazolate under physiological conditions, is a well-known synthetic strategy in medicinal chemistry. To improve our overall understanding of bioisosterism, we have used this example to study the geometrical and energetic aspects
Tjelvar S. G. Olsson +5 more
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Bioisosterism involving replacement of a carboxylic acid substituent by 1H-tetrazole, yielding deprotonated carboxylate and tetrazolate under physiological conditions, is a well-known synthetic strategy in medicinal chemistry. To improve our overall understanding of bioisosterism, we have used this example to study the geometrical and energetic aspects
Tjelvar S. G. Olsson +5 more
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Tetrazoles. Part 49. Alkylation of Tetrazoles with Tetrakis(chloroacetoxymethyl)methane.
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
T. V. Artamonova +2 more
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The azido-tetrazole equilibrium in the thiazolo[2,3-e]tetrazole series [PDF]
Chemistry of Heterocyclic Compounds, 1970 Thiazolo[2, 3-e]tetrazole and its derivatives with electropositive and electronegative substituents have been synthesized. The bromination, thiocyanation, and nitration reactions of some thiazolo[2,3-e]tetrazoles have been studied. By means of the IR spectra, the structure of the compounds synthesized in the crystalline state and in solutions has been ...
T. A. Zakharova +3 more
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Theoretical study of synthetic reaction of tetrazole and tetrazolate anion
International Journal of Quantum Chemistry, 2000Tetrazole (H2CN4) and tetrazolate anion (HCN) are high-energy compounds with a five-membered ring-type structures, which can be easily synthesized by HCN and HN3 and by HCN and N, respectively, in an irreversible reaction. The ab initio methods including MP2/6-31G**, B3LYP/6-31G**, B3LYP/6-311+G(2d,p), and CBS/QB3 from Gaussian 98 program are employed ...
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Use of tetrazoles in catalysis and energetic applications: Recent developments
Molecular Catalysis, 2021M. Nasrollahzadeh +3 more
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Enantioselective Denitrogenative Annulation of 1H-Tetrazoles with Styrenes Catalyzed by Rhodium.
Angewandte Chemie, 2018Sulfonylation of 1H-tetrazoles with triflic anhydride in the presence of chiral rhodium(II) carboxylate dimers causes denitrogenation to generate α-azo rhodium(II) carbenoid species as new types of donor/acceptor carbenoids, which then readily react with
Takayuki Nakamuro +3 more
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4 Medicinal Chemistry of Tetrazoles
1980Publisher Summary Tetrazole itself exhibits no pharmacological activity; however, many of its derivatives possess interesting biological actions. The tetrazole function is metabolically stable and this feature and a close similarity between the acidic character of the tetrazole group and the carboxylic group have inspired syntheses of potential ...
Dharam Paul +4 more
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Tetrazoles: LIII. Microwave-activated acylation of 5-substituted tetrazoles
Russian Journal of Organic Chemistry, 2008The acylation of 5-aryl(hetaryl)tetrazoles with acetic and benzoic anhydrides under microwave irradiation gave the corresponding 2-substituted 5-methyl-and 5-phenyl-1,3,4-oxadiazoles in high yields. The use of microwave activation reduces the reaction temperature by 30–40°C and shortens the reaction time by a factor of 5 to 7.
G. I. Koldobskii +2 more
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Tetrazoles. 33. New method for obtaining functionally substituted tetrazoles
Chemistry of Heterocyclic Compounds, 1997The interaction of 5-methylsulfonyl-1-phenyltetrazole with C-, N-, and O-nucleophiles at 18–20°C gives high yields of 1-phenyltetrazoles that are functionally substituted on the carbon atom of the heteroring. Prospects are examined for the use of 5-methylsulfonyl-1-phenyltetrazole as a universal synthon in the synthesis of tetrazoles with various types
M. A. Gol'tsberg, G. I. Koldobskii
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Thermal decomposition of sodium tetrazolate monohydrate and its mixture with tetrazole
Thermochimica Acta, 1991Abstract The thermal decomposition of sodium tetrazolate monohydrate and its mixture with tetrazole (64% tetrazole) was investigated by differential scanning calorimetry and complex thermal analysis at different heating rates. It was found that the exothermal single-stage decomposition of sodium tetrazolate proceeding at a high rate within the range ...
Anatoly I. Lesnikovich +4 more
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