Results 171 to 180 of about 132,891 (291)

<i>Humulus lupulus</i> (Hop)-Derived Chemical Compounds Present Antiproliferative Activity on Various Cancer Cell Types: A Meta-Regression Based Panoramic Meta-Analysis. [PDF]

open access: yesPharmaceuticals (Basel)
Tsionkis G   +9 more
europepmc   +1 more source

Development of a Novel Polyleucine‐Based Immunopotentiator for Subunit Vaccines Against Group A Streptococcus

open access: yesSmall, EarlyView.
Self‐assembling amphiphilic peptide L15K6 is used as a novel immunoadjuvant for the development of a Group A Streptococcus vaccine. Robust antigen‐specific IgG responses are generated and manage to kill isolated strains of Group A Streptococcus. Cellular and bulk RNA sequencing data reveals that L15K6 regulates immune responses potentially through TLR ...
Lantian Lu   +25 more
wiley   +1 more source

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

open access: yesSmall, EarlyView.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi   +12 more
wiley   +1 more source

Photo‐induced proton release of spiropyran‐derived nanomaterials for mRNA delivery in hard‐to‐transfect cells

open access: yesSmart Molecules, EarlyView.
Light‐induced proton release from spiropyran can disrupt the stability of both nanoparticles and endosomal membranes, thereby promoting endosomal escape and ultimately enhancing transfection performance. Abstract Messenger RNA (mRNA) therapy has been explored as a treatment for various genetic disorders. Significant progress has been made in developing
Caiwei Lu   +6 more
wiley   +1 more source

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