Results 201 to 210 of about 132,891 (291)

A thermoplastic microfluidic platform with integrated electrospun scaffolds for assessing brain cell‐specific drug selectivity

open access: yesVIEW, EarlyView.
Schematic representation of the microfluidic platform with its advantages. Abstract A major challenge in pharmacology is the limited selectivity of therapeutic compounds toward specific tissues or cells. Drugs often distribute systemically before reaching the intended site of action, affecting nontarget cells and potentially reducing efficacy or ...
Maria Testa   +8 more
wiley   +1 more source

Trace Element Analysis in Human Neuroblastoma Cell Spheroids Supplemented With ZnCl2 by Micro‐XRF

open access: yesX-Ray Spectrometry, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor of childhood, is responsible for ~10% of pediatric cancer deaths and has high potential for metastasis. Metals are extremely important in biological processes, and changes in their levels have been correlated with the development of cancerous growth.
J. E. P. Rosa   +10 more
wiley   +1 more source

Effect of Intracanal Medications on the Viability of Human Periodontal Ligament‐Derived Mesenchymal Stem Cells

open access: yesAustralian Endodontic Journal, EarlyView.
ABSTRACT This in vitro study evaluated the effects of intracanal medications on the metabolic activity and adhesion of human periodontal ligament‐derived mesenchymal stem cells. Tested groups included Control (without medication), Triple Antibiotic Paste (TAP), Double Antibiotic Paste (DAP), calcium hydroxide with saline, calcium hydroxide with 2 ...
Arian Braido   +7 more
wiley   +1 more source

Biological Characterization of 3D-Printed, Sintered Hydroxyapatite Scaffolds Obtained by Fused Filament Fabrication: An In Vitro Study. [PDF]

open access: yesJ Funct Biomater
Shan E   +9 more
europepmc   +1 more source

Analysis of Solubility, pH, Antimicrobial Action and Cytotoxicity of Calcium Hydroxide Paste Associated With Ambroxol Hydrochloride

open access: yesAustralian Endodontic Journal, EarlyView.
ABSTRACT This study evaluated the association of ambroxol hydrochloride with calcium hydroxide paste as intracanal medication to enhance antimicrobial action on biofilm without affecting pH, solubility and cytotoxicity. Calcium hydroxide (CH) paste and formulations with different ambroxol concentrations were placed into artificial teeth conditioned in ...
Thaís Ferreira Rodrigues Mota   +6 more
wiley   +1 more source

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng   +10 more
wiley   +1 more source

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