Results 91 to 100 of about 24,486 (253)

Piqueria trinervia as a source of metabolites against Giardia intestinalis

Pharmaceutical Biology, 2017
Context: Piqueria trinervia Cav. (Asteraceae) is a plant species with a long history in traditional medicine to cure diarrhoea and other digestive disorders.
Yadira Rufino-González, Martha Ponce-Macotela, Manuel Jiménez-Estrada, Candy N. Jiménez-Fragoso, Guadalupe Palencia, Gabriel Sansón-Romero, Anahi Anzo-Osorio, Mario N. Martínez-Gordillo   +7 more
doaj   +1 more source

Comparative analysis of toxic responses of organic extracts from diesel and selected alternative fuels engine emissions in human lung BEAS-2B cells [PDF]

, 2016
This study used toxicogenomics to identify the complex biological response of human lung BEAS-2B cells treated with organic components of particulate matter in the exhaust of a diesel engine.
Beranek, Vít, Brzicová, Táňa, Ciganek, Miroslav, Kléma, Jiří, Líbalová, Helena, Machala, Miroslav, Neča, Jiří, Pěnčíková, Kateřina, Rossner, Pavel, Sikorová, Jitka, Topinka, Jan, Vojtíšek-Lom, Michal, Vrbová, Kristýna   +12 more
core   +2 more sources

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Effect of Fruit Maturation Stage on the Chemical Composition and Antioxidant and Cytotoxic Activities of Piper nigrum Essential Oil

Flavour and Fragrance Journal, EarlyView.
The essential oils of Piper nigrum show marked chemical and biological variation across fruit maturation stages. Ripe fruits yield oils with the strongest antioxidant and cytotoxic activities, demonstrating that maturation directly modulates volatile composition and enhances the bioactive potential of this aromatic species.
Marcio Marcelo da Siva Pessoa, Jorddy Neves Cruz, Ingryd Nayara de Farias Ramos, André Salim Khayat, Eloisa Helena de Aguiar Andrade, José de Arimatéia Rodrigues do Rego, Davi do Socorro Barros Brasil   +6 more
wiley   +1 more source

Eubiotic effect of a dietary acidifier (potassium diformate) on the health status of cultured Oreochromis niloticus

Journal of Advanced Research, 2015
In connection with the global demand for safe human food and the production of environmentally friendly aquaculture products, acidifiers are natural organic acids and salts that have received considerable attention as animal-feed additives.
Nermeen M. Abu Elala, Naela M. Ragaa
doaj   +1 more source

Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence [PDF]

, 2015
STAT1 loss has previously been implicated in cell line studies to modify prostate cancer cell growth and survival, however the clinical significance of this has not previously been established.
Edwards, Joanne, Hatziieremia, Sophia, McCall, Pamela, Mohammed, Zahra, Roseweir, Antonia K., Underwood, Mark A., Willder, Jennifer M.   +6 more
core   +1 more source

Melanoma Cells Exposed to Clomiphene Citrate Respond With Cell Cycle Arrest and Reduced Invasiveness

Journal of Applied Toxicology, EarlyView.
ABSTRACT Epidemiological studies have suggested that clomiphene citrate (CC) exposure may increase the risk of malignant melanoma, but mechanisms are unknown. We investigated the effects of CC on melanoma cell line A375. Cells were treated with CC at 2, 20, 200, and 2000 ng/mL, followed by assessment of cell viability and metabolism, cell cycle ...
Thaís S. Ribeiro, Felipe H. S. Silva, Ana Paula G. S. Miranda, Isabella T. Borges, Pedro H. D. M. Prazeres, Marcia C. F. Ferreira, Enio Ferreira, Fernando M. Reis, Helen L. Del Puerto   +8 more
wiley   +1 more source

Effects of Curcumin in Combination with doxorubicin in Human Colorectal Cancer Cell Line

Asian Pacific Journal of Cancer Biology, 2019
Background: Colorectal cancer (CRC) is one of the main cancer related morbidity wordwidth. New therapeutic strategies are required for CRC. Anthracycline drugs such as doxorubicin (DOX) remain one of the most active wide-spectrum and cost-effective drugs
Azim Akbarzadeh Khiyavi
doaj   +3 more sources

Comparison of efficacies of different bone substitutes adhered to osteoblasts with and without extracellular matrix proteins

Journal of Dental Sciences, 2013
Background/purpose: Regeneration of bony tissue is a major goal in periodontal and implant surgery. The adhesion efficacy of osteogenic cells to bone substitutes is a determinant for osteogenesis.
Li-Ling Tseng, Chin-Man Ho, Wei-Zhe Liang, Yao-Dung Hsieh, Chung-Ren Jan   +4 more
doaj   +1 more source