Results 111 to 120 of about 326,662 (301)

pH‐Responsive Sodium Alginate Micro‐Nano Hydrogels for Oral Insulin Delivery: Enhancing Therapeutic Efficacy and Reducing Hypoglycemic Risk

open access: yesFood Frontiers, EarlyView.
Schematic illustration of pH‐responsive SC@AP@INS for oral insulin delivery. (A) pH‐responsive mechanism of sodium alginate‐based hydrogels. (B) Preparation of drug‐loaded microsphere gel via the electrospray method. The controlled release of drug‐loaded micelles in the colon enhances insulin delivery efficiency while minimizing systemic exposure and ...
Minghui Kong   +3 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

open access: yesInterdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui   +12 more
wiley   +1 more source

Achieving superior therapeutic effects on methicillin‐resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer

open access: yesInterdisciplinary Medicine, EarlyView.
The sulfonated zwitterionic photosensitizer (PYSO3) is synthesized by reacting maleic anhydride derivatives with 4‐aminopyridine to form PY, followed by sulfonation with 1,4‐butane sultone. It exhibits both photothermal and photodynamic properties, enabling effective eradication of MRSA and biofilms, as well as promoting wound healing in mice ...
Changxu Zhu   +10 more
wiley   +1 more source

Bio‐Inspired, Zwitterionic Copolymers with Amphiphilic Character

open access: yesMacromolecular Rapid Communications, EarlyView.
Zwitterionic copolymers based on arginine‐derived monomers are produced by xanthate‐supported photo‐iniferter reversible‐addition‐fragmentation chain‐transfer polymerization. Experiments in relevant conditions show that the designed (co)polymers hardly interact with biologically relevant proteins and enzymes such as bovine serum albumine (BSA), fetal ...
Theresa M. Lutz   +4 more
wiley   +1 more source

Ex Vivo Evaluation of Poly(Solketal Acrylate) Nanoparticles for Intravitreal Drug Delivery to the Posterior Eye Segment

open access: yesMacromolecular Rapid Communications, EarlyView.
Nile Red‐loaded poly(solketal acrylate) nanoparticles enable fluorescence tracking and exhibit nontoxic profiles in retinal cells. Enhanced cellular uptake and deep retinal penetration after intravitreal injection highlight their excellent potential for targeted ocular drug delivery to the posterior segment of the eye.
Yasaman Pourdakheli Hamedani   +6 more
wiley   +1 more source

Genomic and functional insights into Lactiplantibacillus plantarum UTNGt3 from Ecuadorian Amazon Chrysophyllum oliviforme: a safe and promising probiotic

open access: yesFrontiers in Microbiology
IntroductionLactiplantibacillus plantarum is a versatile lactic acid bacterium (LAB) recognized for its probiotic potential, with key traits such as adhesion to intestinal epithelial cells and tolerance to bile salts and gastric acid being essential for ...
Gabriela N. Tenea   +4 more
doaj   +1 more source

Toward Dynamic Liquid Cell Scaffold: Photoreversible Ion Gels Exhibiting Light‐Induced Sol‐Gel Transitions

open access: yesMacromolecular Rapid Communications, EarlyView.
Light‐programmable, non‐cytotoxic ion gels based on ABC triblock copolymers undergo photoreversible sol‐gel transitions, crossing the rheological boundary (tan δ ∼ 1). UV–vis light irradiation modulates the lifetime of reversible junctions, switching the scaffold between liquid‐like and solid (gel)‐like states.
Aya Saruwatari   +4 more
wiley   +1 more source

Crosslinked Gelatin‐Polycaprolactone Scaffolds: Balancing Biocompatibility and Inflammatory Response for Tissue Engineering Applications

open access: yesPolymer Engineering &Science, EarlyView.
Crosslinked gelatin‐functionalized PCL scaffolds exhibited enhanced hydrophilicity, structural stability, and porous interactions. In vitro assays demonstrated improved osteoblast adhesion, viability, and proliferation without cytotoxicity, while in vivo evaluation showed no adverse inflammatory response, supporting their potential application in ...
Fernanda Ramírez‐Ruiz   +7 more
wiley   +1 more source

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