Results 71 to 80 of about 11,247 (202)
Addressing the Issue of Tetrodotoxin Targeting
Marine Drugs, 2018 This review is devoted to the medical application of tetrodotoxin (TTX), a potent non-protein specific blocker of voltage-gated sodium (NaV) channels. The selectivity of action, lack of affinity with the heart muscle NaV channels, and the inability to ...
Daria I. Melnikova +2 more
doaj +1 more source
Five Decades of Dispute: A Triptych. E. J. Corey
The Chemical Record, EarlyView.In his 2004 Priestley Medal address, E. J. Corey stated, “On May 4, 1964, I suggested to my colleague R. B. Woodward a simple explanation involving the symmetry of the perturbed (HOMO) molecular orbitals for the stereoselective cyclobutene/1,3‐butadiene and 1,3,5‐hexatriene/cyclohexadiene conversions that provided the basis for the further development ...
Jeffrey I. Seeman
wiley +1 more source
Strategies for enhancing sensitivity in lateral flow assays
VIEW, EarlyView.Lateral flow assays (LFAs) are essential for cost‐effective, rapid point‐of‐care diagnostics. However, conventional colourimetric LFAs often lack the sensitivity required for low‐abundance biomarkers. This review evaluates six enhancement strategies: flow modulation, sample preconcentration, advanced reporters, chemical signal amplification, structural
Aylar Eslami Saed +3 more
wiley +1 more source
Tetrodotoxin-resistant sodium channels in neuropathic pain
, 2000 Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury.
Jenny Fjell Hjelmström (19527955)
core +1 more source
Pediatric Neurology Briefs, 2005 The effects of puffer fish poisoning on peripheral nerve were investigated in 4 of 9 patients (7 adults and 2 children) treated at the Prince of Wales Hospital, Sydney, Australia.
J Gordon Millichap
doaj +1 more source
Australian Endodontic Journal, EarlyView.ABSTRACT Achieving profound local anaesthesia during mandibular molar root canal treatment can be challenging. This study evaluated procedural pain and supplemental anaesthesia used, considering endodontic diagnosis and buccal bone morphology. Seventy‐seven patients undergoing primary root canal treatment completed a post‐treatment survey questionnaire
Emily Kopec +7 more
wiley +1 more source
6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human
Andrology, EarlyView.ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human prostate and its role in smooth muscle regulation.
Alline Araujo Curiel +12 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
Evaluation of the Occurrence of Tetrodotoxin in Bivalve Mollusks from the Portuguese Coast
Journal of Marine Science and Engineering, 2019 Occurrence of tetrodotoxin (TTX), a potent natural neurotoxin, in marine organisms and seafood from the European Union has been of increasing concern due to its relatively recent detection in bivalve mollusks and gastropods.
Susana Margarida Rodrigues +4 more
doaj +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source