Results 91 to 100 of about 11,247 (202)

POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS

Разработка и регистрация лекарственных средств, 2019
The article describes some approaches to choice of the most potent non-narcotic analgesics among agents investigated in various R&D stages. Preparations non-narcotic analgesics for relief of severe and moderate pain are relatively new area of ...
A. V. Sosnov, S. V. Sadovnikov, F. M. Semchenko, K. A. Rufanov, V. N. Tohmahchi, A. A. Sosnova, I. A. Tyurin   +6 more
doaj  

The Toxins of Nemertean Worms

Toxins, 2019
Most ribbon worms (phylum: Nemertea) are found in marine environments, where they act as predators and scavengers. They are characterized by an eversible proboscis that is used to hunt for prey and thick mucus covering their skin.
Ulf Göransson, Erik Jacobsson, Malin Strand, Håkan S. Andersson   +3 more
doaj   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Stabilization and rectification of muscle fiber membrane by tetrodotoxin

, 1960
The mode of action of tetrodotoxin on the frog muscle fiber membrane has been analyzed with the aid of intracellular microelectrodes. Tetrodotoxin of 10–7 concentration made the applied cathodal current ineffective in producing action potential, whereas
Yoshio Ohkubo, Takehiko Deguchi, Norimoto Urakawa, Toshio Narahashi   +3 more
core   +1 more source

Supplementary NMR-package for "A Concise Synthesis of Tetrodotoxin"

, 2022
This data package contains Supplementary Materials in form of raw NMR.fid files for our manuscript entitled "A Concise Synthesis of Tetrodotoxin"
Klaus-Peter Rühmann, Nina Strassner, Kendall N. Houk, Dirk Trauner, Hiroyasu Ando, David B. Konrad, Bryan S. Matsuura, Belinda E. Hetzler   +7 more
core   +1 more source

Tetrodotoxin-Producing Bacteria: Detection, Distribution and Migration of the Toxin in Aquatic Systems

Toxins, 2017
This review is devoted to the marine bacterial producers of tetrodotoxin (TTX), a potent non-protein neuroparalytic toxin. In addition to the issues of the ecology and distribution of TTX-producing bacteria, this review examines issues relating to toxin ...
Timur Yu. Magarlamov, Daria I. Melnikova, Alexey V. Chernyshev   +2 more
doaj   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Puffer smells tetrodotoxin [PDF]

, 2013
Behavioral observation was conducted to test whether olfaction is functional to detect tetrodotoxin (TTX) in tiger puffer Takifugu rubripes using Y-maze. We placed either agarose carrier or one agarose and one agarose containing TTX (200 MU) at each head
Okita, Kogen, Arakawa, Osamu, Sakakura, Yoshitaka, Takatani, Tomohiro, Yamazaki, Hideki, Yamane, Hikaru, Sakiyama, Kazutaka, Niina, Shinya   +7 more
core   +1 more source

Isolation and Identification of a New Tetrodotoxin-Producing Bacterial Species, Raoultella terrigena, from Hong Kong Marine Puffer Fish Takifugu niphobles

Marine Drugs, 2011
Puffer fish, Takifugu niphobles, collected from the Hong Kong coastal waters were screened for tetrodotoxin-producing bacteria. A Gram-negative, non-acid-fast, non-sporing and rod shaped bacterial strain (designated as gutB01) was isolated from the ...
Fred Wang-Fat Lee, Peter Hoi-Fu Yu, Vincent Chung-Him Yu, Kin-Chung Ho   +3 more
doaj   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source