Results 91 to 100 of about 10,876 (160)
Establishing a protocol to measure tetrodotoxin (TTX) levels in small bodied newts (genus Lissotriton) in western Europe [PDF]
Tetrodotoxin (TTX) is a defence toxin most commonly found in marine organisms, and amphibians are the only land vertebrates (tetrapods) which are known to produce TTX.
Wagstaff, RM
core +1 more source
Toxins, 2019 A novel polyclonal antibody against tetrodotoxin (TTX) was raised using its haptenic antigen, where 4,9-anhydroTTX was reacted with 1,2-ethanedithiol and this derivative was further reacted with keyhole limpet hemocyanin (KLH).
Shigeru Sato +3 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend. In this study, we describe how persistent inward currents (PICs) and nonlinear firing dynamics mature in slow‐type (green) and fast‐type (purple) motoneurons (MNs) during the second and third postnatal weeks of development in mice.
Simon A. Sharples, Gareth B. Miles
wiley +1 more source
Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor
Marine Drugs, 2019 Voltage-gated sodium channels (NaVs) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) NaV subtype with saxitoxin (STX),
Kanna Adachi +3 more
doaj +1 more source
Purification and Characterization of Tetrodotoxin-binding Substance in Shore Crab Hemolymph [PDF]
, 2001 P(論文)テトロドトキシン(TTX)は古くからフグ毒の主成分として知られる。1964年にカリフォルニアイモリの毒がTTXに同定されて以来,これまでに微生物から両生類にいたる多種の生物に存在することが明らかにされてきた。TTXは神経細胞のNaチャンネルを選択的にブロックして,神経の興奮を阻害する作用を持つ神経毒であるとされている。TTXを保有しない一般の硬骨魚類のTTXの腹腔内投与に対する抵抗性はマウスと同程度の体重20g当たり約1MUである。これに対して ...
楠田, 理一 +9 more
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The Journal of Physiology, EarlyView.Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza +4 more
wiley +1 more source
Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
Toxins, 2014 Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan.
Vaishali Bane +4 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 21, Page 6481-6500, November 2026.Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley +1 more source
Tetrodotoxin-resistant sodium channels in neuropathic pain
, 2000 Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury.
Jenny Fjell Hjelmström (19527955)
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Stereoselective and Efficient Total Synthesis of Optically Active Tetrodotoxin from d-Glucose
, 2016 A stereoselective and efficient total synthesis of optically active tetrodotoxin (TTX) is described. A polyfunctionalized key cyclitol compound containing branched-chains for the synthesis of TTX was prepared from d-glucose employing the Henry reaction ...
Yasuhiro Kajihara (836272) +10 more
core +3 more sources