Results 71 to 80 of about 17,003 (167)

Dorso‐Ventral and Night‐Day Regulation of Extracellular K+ Dynamics in Mouse Hippocampal Astrocytes

Glia, Volume 74, Issue 9, September 2026.
Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Nariman Kiani, Kabeer Abubakar, Tin Luka Petanjek, Monique Esclapez, Anton Ivanov, Christophe Bernard   +5 more
wiley   +1 more source

Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders

The Journal of Clinical Investigation
Multiple approaches have targeted voltage-gated sodium (Nav) channels for analgesia. In this issue of the JCI, Shin et al. identified a peptide aptamer, NaViPA1, carrying a short polybasic motif flanked by serine residues in a structurally disordered ...
Sulayman D. Dib-Hajj, Stephen G. Waxman
doaj   +1 more source

Electrostatic tuning of NaV channel activation by the domain II S3–S4 extracellular loop

The Journal of Physiology, Volume 604, Issue 17, Page 7210-7224, 1 September 2026.
Abstract figure legend Voltage‐gated sodium (NaV) channels are critical for electrical signalling, yet the molecular determinants that tune isoform‐specific activation remain incompletely understood. Here, we show that charged amino acids in the extracellular DII S3–S4 loop of NaV1.7 play a key role in setting voltage‐dependent activation.
Ashvriya Thapa, Lotten Ragnarsson, Hue Tran, Angelo Keramidas, Jennifer R. Deuis, Irina Vetter   +5 more
wiley   +1 more source

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

Marine Drugs, 2019
Voltage-gated sodium channels (NaVs) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) NaV subtype with saxitoxin (STX),
Kanna Adachi, Hayate Ishizuka, Minami Odagi, Kazuo Nagasawa   +3 more
doaj   +1 more source

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Toxins, 2014
Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan.
Vaishali Bane, Mary Lehane, Madhurima Dikshit, Alan O'Riordan, Ambrose Furey   +4 more
doaj   +1 more source

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Toxins, 2017
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal, M. Carmen Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +7 more
doaj   +1 more source

Concentrations of Tetrodotoxin (TTX) and Its Analogue 4,9-Anhydro TTX in Different Tissues of the Silver-Cheeked Pufferfish (Lagocephalus sceleratus, Gmelin, 1789) Caught in the South-Eastern Mediterranean Sea, Lebanon. [PDF]

Toxins (Basel), 2022
Hassoun AER, Ujević I, Jemaa S, Roje-Busatto R, Mahfouz C, Fakhri M, Nazlić N.   +6 more
europepmc   +1 more source

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

Toxins, 2018
Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang, Chengcheng Han, Si Chen, Le Li, Jingjing Zong, Junjie Zeng, Guangming Mei   +6 more
doaj   +1 more source

Tetrodotoxin‐resistant mechanosensitivity and L‐type calcium channel‐mediated spontaneous calcium activity in enteric neurons

Experimental Physiology
Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell ...
Richard J. Amedzrovi Agbesi, Amira El Merhie, Nick J. Spencer, Tim Hibberd, Nicolas R. Chevalier   +4 more
doaj   +1 more source

Tetrodotoxin: The State-of-the-Art Progress in Characterization, Detection, Biosynthesis, and Transport Enrichment

Marine Drugs
Tetrodotoxin (TTX) is a neurotoxin that binds to sodium channels and blocks sodium conduction. Importantly, TTX has been increasingly detected in edible aquatic organisms.
Xinxin Zhang, Kun Qiao, Ruimin Cui, Min Xu, Shuilin Cai, Qilin Huang, Zhiyu Liu   +6 more
doaj   +1 more source