Results 21 to 30 of about 17,204 (113)

Prostaglandin E2 Has No Effect on Two Components of Tetrodotoxin-Resistant Na+ Current in Mouse Dorsal Root Ganglion

Journal of Pharmacological Sciences, 2007
One possible mechanism underlying inflammation-induced sensitization of the primary afferent neuron is the upregulation of tetrodotoxin-resistant (TTX-R) Na+ current by inflammatory mediators such as prostaglandins.
Taixing Zheng, Jun-ichi Kakimura, Tomoya Matsutomi, Chizumi Nakamoto, Nobukuni Ogata   +4 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults

Toxins, 2020
Tetrodotoxin (TTX) is a highly specific voltage-gated sodium channel (VGSC) blocker in clinical evaluation as a peripheral-acting analgesic for chronic pain. This study presents the first published results of the safety including cardiac liability of TTX
Mojgan Kavoosi, Terry E. O’Reilly, Mehran Kavoosi, Peng Chai, Caroline Engel, Walter Korz, Christopher C. Gallen, Robert M. Lester   +7 more
doaj   +1 more source

Does Ocean Sunfish Mola spp. (Tetraodontiformes: Molidae) Represent a Risk for Tetrodotoxin Poisoning in the Portuguese Coast?

Marine Drugs, 2022
Tetrodotoxin (TTX) is a potent neurotoxin naturally occurring in terrestrial and marine organisms such as pufferfish. Due to the risk of TTX poisoning, fish of Tetraodontidae family and other puffer-related species must not be placed in the EU markets ...
Miguel Baptista, Ana Catarina Braga, Rui Rosa, Pedro Reis Costa   +3 more
doaj   +1 more source

Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity

Toxins, 2019
Tetrodotoxin (TTX) is one of the most potent naturally occurring neurotoxins. Initially TTX was associated with human food intoxications in Japan, but nowadays, concerns about the human health risks posed by TTX have increased in Europe after the ...
Andrea Boente-Juncal, Carmen Vale, Manuel Cifuentes, Paz Otero, Mercedes Camiña, Mercedes Rodriguez-Vieytes, Luis Miguel Botana   +6 more
doaj   +1 more source

Behavioral and Chemical Ecology of Marine Organisms with Respect to Tetrodotoxin

Marine Drugs, 2010
The behavioral and chemical ecology of marine organisms that possess tetrodotoxin (TTX) has not been comprehensively reviewed in one work to date. The evidence for TTX as an antipredator defense, as venom, as a sex pheromone, and as an attractant for TTX-
Becky L. Williams
doaj   +1 more source

Gustatory Detection of Tetrodotoxin and Saxitoxin, and Its Competitive Inhibition by Quinine and Strychnine in Freshwater Fishes

Marine Drugs, 2011
Fish detect extremely low levels of marine toxins tetrodotoxin (TTX) and saxitoxin (STX) via the specialized gustatory receptor(s). Physiological and pharmacological studies show that receptor(s) for TTX and STX are distinct from those which detect ...
Toshiaki J. Hara
doaj   +1 more source

Seasonal and Spatial Variations in Bacterial Communities From Tetrodotoxin-Bearing and Non-tetrodotoxin-Bearing Clams

Frontiers in Microbiology, 2020
Tetrodotoxin (TTX) is one of the most potent naturally occurring compounds and is responsible for many human intoxications worldwide. Paphies australis are endemic clams to New Zealand which contain varying concentrations of TTX. Research suggests that P.
Laura Biessy, Laura Biessy, Laura Biessy, John K. Pearman, Kirsty F. Smith, Ian Hawes, Susanna A. Wood   +6 more
doaj   +1 more source

No Evidence for a Culturable Bacterial Tetrodotoxin Producer in Pleurobranchaea maculata (Gastropoda: Pleurobranchidae) and Stylochoplana sp. (Platyhelminthes: Polycladida)

Toxins, 2015
Tetrodotoxin (TTX) is a potent neurotoxin found in the tissues of many taxonomically diverse organisms. Its origin has been the topic of much debate, with suggestions including endogenous production, acquisition through diet, and symbiotic bacterial ...
Lauren R. Salvitti, Susanna A. Wood, Paul McNabb, Stephen Craig Cary   +3 more
doaj   +1 more source

Differing alterations of sodium currents in small dorsal root ganglion neurons after ganglion compression and peripheral nerve injury

Molecular Pain, 2008
Voltage-gated sodium channels play important roles in modulating dorsal root ganglion (DRG) neuron hyperexcitability and hyperalgesia after peripheral nerve injury or inflammation.
Song Xue-Jun, Huang Zhi-Jiang
doaj   +1 more source

The skin microbiome facilitates adaptive tetrodotoxin production in poisonous newts

eLife, 2020
Rough-skinned newts (Taricha granulosa) use tetrodotoxin (TTX) to block voltage-gated sodium (Nav) channels as a chemical defense against predation.
Patric M Vaelli, Kevin R Theis, Janet E Williams, Lauren A O'Connell, James A Foster, Heather L Eisthen   +5 more
doaj   +1 more source