Results 81 to 90 of about 16,950 (172)

VMAT‐DAT‐Dopamine Regulatory System Involved in the Protective Effect of 3‐n‐Butylphthalide Against Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Proposed mechanism underlying NBP protection against ischemic stroke. NBP exerts neuroprotection against cerebral ischemic injury partially via upregulating the VMAT‐DAT‐dopamine cycle to improve synaptic dysfunction. Activation of D1R and adenosine A1Rs participates in the relevant downstream signalling cascades.
Xiao‐Ting Zhou, Qin Liu, Ming Chen, Ruo‐Xi Zhang, Yi‐Ling Su, Ding‐Feng Su, Ai‐Jun Liu   +6 more
wiley   +1 more source

Novel Polyclonal Antibody Raised against Tetrodotoxin Using Its Haptenic Antigen Prepared from 4,9-anhydrotetrodotoxin Reacted with 1,2-Ethaneditiol and Further Reacted with Keyhole Limpet Hemocyanin

Toxins, 2019
A novel polyclonal antibody against tetrodotoxin (TTX) was raised using its haptenic antigen, where 4,9-anhydroTTX was reacted with 1,2-ethanedithiol and this derivative was further reacted with keyhole limpet hemocyanin (KLH).
Shigeru Sato, Suzuka Takaishi, Ko Yasumoto, Shugo Watabe   +3 more
doaj   +1 more source

Early Developmental Neuronal Activity Impacts Oligodendrocyte Differentiation Through AMPA Receptors

Glia, Volume 74, Issue 8, August 2026.
In early brain development, neuronal activity reduces OPC differentiation. Decreased neuronal activity changes oligodendrocyte gene expression, including upregulating glutamate receptor genes. AMPA signaling regulates the final stages of OPC differentiation.
Tessa E. Allen, Graham Peet, Luis E. Gomez Wulschner, Won Chan Oh, Wendy B. Macklin   +4 more
wiley   +1 more source

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

Marine Drugs, 2019
Voltage-gated sodium channels (NaVs) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) NaV subtype with saxitoxin (STX),
Kanna Adachi, Hayate Ishizuka, Minami Odagi, Kazuo Nagasawa   +3 more
doaj   +1 more source

Astrocytic mGluR5 Regulation of Synaptic Transmission is Activity‐Dependent in Adult Rats

Glia, Volume 74, Issue 8, August 2026.
In adulthood, astrocytic mGluR5 increases synaptic efficacy through presynaptic A2ARs. This occurs when a small number of synapses are activated simultaneously. This pathway is abolished when numerous synapses are recruited. ABSTRACT Data accumulated over the last two decades have demonstrated that astrocytes play key roles in the regulation of ...
Sarah Mountadem, Muna L. Hilal, Dylan Pommier, Dorian Arnouil, Valentin Clément Langlais, Vincent Simon, Aurélie Amadio, Marie Miegebielle, Sébastien Marais, Charlène Joséphine, Astrid Cannich, Marjorie Varilh, Julien Bourel, Daniela Cota, Giovanni Marsicano, Alexis‐Pierre Bemelmans, Philippe Ciofi, Stéphane Henri Richard Oliet, Aude Panatier   +18 more
wiley   +1 more source

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Toxins, 2014
Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan.
Vaishali Bane, Mary Lehane, Madhurima Dikshit, Alan O'Riordan, Ambrose Furey   +4 more
doaj   +1 more source

Pufferfish exposure and presumed tetrodotoxicosis in Australian dogs: 372 cases (2007–2018)

Australian Veterinary Journal, Volume 104, Issue 8, Page 497-508, August 2026.
Introduction Tetrodotoxin (TTX) is a neurotoxin found in pufferfish that results in the blockade of excitatory conduction and clinical signs including gastrointestinal upset and paralysis. The objectives of this study were to describe the epidemiology of pufferfish exposure and presumed tetrodotoxicosis in dogs, and to determine associations with the ...
J Hanson, CR Sharp, EM Leister
wiley   +1 more source

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Toxins, 2017
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal, M. Carmen Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +7 more
doaj   +1 more source

Concentrations of Tetrodotoxin (TTX) and Its Analogue 4,9-Anhydro TTX in Different Tissues of the Silver-Cheeked Pufferfish (Lagocephalus sceleratus, Gmelin, 1789) Caught in the South-Eastern Mediterranean Sea, Lebanon. [PDF]

Toxins (Basel), 2022
Hassoun AER, Ujević I, Jemaa S, Roje-Busatto R, Mahfouz C, Fakhri M, Nazlić N.   +6 more
europepmc   +1 more source

Memantine prevents acute stress‐induced memory deficits by reversing sex‐dependent pathophysiological glutamatergic alterations in the dorsal hippocampus

British Journal of Pharmacology, Volume 183, Issue 16, Page 4939-4952, August 2026.
Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi, Lidia Diolosà, Giuseppe Aceto, Claudia Marchetti, Federica Geraci, Konstantinos Partsinevelos, Silvia Rizzo, Margherita Grasso, Filippo Caraci, Francesco Bellia, Giovanni Li Volti, Angela Maria Amorini, Marcello D′Ascenzo, Gian Marco Leggio   +13 more
wiley   +1 more source