Results 71 to 80 of about 28,419 (196)
Marine Drugs, 2020 A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora
Daria I. Melnikova +1 more
doaj +1 more source
Identification of TREK channels in mouse intracardiac ganglion neurons
The Journal of Physiology, EarlyView.Abstract figure legend Role of TWIK‐related K+ (TREK) channels in intracardiac ganglion neurons. CD‐1 mice were used to establish primary cultures of intracardiac neurons for immunochemical characterization and patch‐clamp electrophysiology. Intracardiac neurons express functional TREK channels, which modulate neuronal excitability by regulating ...
Ana Campos‐Rios +9 more
wiley +1 more source
Dynamic memory in rodent C‐fibres and its impact on spinal nociceptive processing
The Journal of Physiology, EarlyView.Abstract figure legend Nociceptive C‐fibres display activity‐dependent slowing (ADS) whereby successive action potentials are conducted progressively slower thus regulating the temporal relay of pain signals. This study shows that the ADS induced by short stimulus trains (which mimic stimulus evoked firing, shown in orange) is modified by prior ...
Atanaska N. Velichkova, Carole Torsney
wiley +1 more source
Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1
The Journal of Physiology, EarlyView.Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang +2 more
wiley +1 more source
Toxins, 2020 Some nemertean species from the genus Cephalothrix accumulate tetrodotoxin (TTX) in extremely high concentrations. The current study is the first to provide high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) data on tetrodotoxin
Anna E. Vlasenko, Timur Yu. Magarlamov
doaj +1 more source
Recent research progress in tetrodotoxin detection and quantitative analysis methods
Frontiers in ChemistryTetrodotoxin (TTX) is a highly potent and widely distributed ion-channel marine neurotoxin; it has no specific antidote and poses a great risk to human health.
Chao Lin +10 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Highlights of the main electrophysiological differences between MDJ neurons that project to the IO and those that do not. IO‐projecting neurons fire rebound spikes and are spontaneously active at higher frequencies. The bottom panel shows the anatomical connectivity of the MDJ with both excitatory and newly discovered inhibitory ...
Stijn Voerman +5 more
wiley +1 more source
, 2019 (a) Profile of secretion of salivary fluid in response to pilocarpine treatment in the presence or absence of tetrodotoxin (TTX) in submandibular glands of rats. Submandibular glands were stimulated with 10 μM pilocarpine in the absence of TTX.
Takanori Narita (25602) +3 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend. In this study, we describe how persistent inward currents (PICs) and nonlinear firing dynamics mature in slow‐type (green) and fast‐type (purple) motoneurons (MNs) during the second and third postnatal weeks of development in mice.
Simon A. Sharples, Gareth B. Miles
wiley +1 more source
The Journal of Clinical InvestigationMultiple approaches have targeted voltage-gated sodium (Nav) channels for analgesia. In this issue of the JCI, Shin et al. identified a peptide aptamer, NaViPA1, carrying a short polybasic motif flanked by serine residues in a structurally disordered ...
Sulayman D. Dib-Hajj, Stephen G. Waxman
doaj +1 more source