Results 31 to 40 of about 10,876 (160)
A Progress on the Application of Tetrodotoxin [PDF]
E3S Web of Conferences, 2021 Tetrodotoxin (TTX), a blocker of sodium channels, exists in the pufferfish, amphibians, and octopus, and originated in endosymbiont-vibrio. Researches have confirmed that TTX affected the action potential through the regulation of voltage-gated sodium ...
Wang Zhaojia, Zhou Zhenning
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Total Synthesis of Tetrodotoxin and 9-epiTetrodotoxin [PDF]
, 2023 Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and an-algesic effects. Here, we present a scalable asymmetric synthesis of TTX and 9-epiTTX from the abundant chemical feed-stock furfuryl ...
Yuze, Sun +19 more
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Genetic basis for tetrodotoxin (TTX) resistance in Nassarius [PDF]
, 2020 Understanding the genetic basis in animals possessing toxin could provide us significant insights into the adaptive evolution in toxin resistance. The reason of toxin resistance may refer to the mutation in sodium channels or the toxin-binding proteins.
Shanmei Zou, Yuxiao Hua
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Paralytic shellfish toxins (PSTs) and tetrodotoxin (TTX) of Korean pufferfish
Fisheries and Aquatic Sciences, 2021 Paralytic shellfish toxins (PSTs) and tetrodotoxin (TTX) are neurotoxins that display pharmacological activity that is similar to that of specific sodium channel blockers; they are the principle toxins involved in shellfish and puffer fish poisoning. In Korea, puffer fish is a very popular seafood, and several cases of accidental poisoning by TTX have ...
Ka Jeong Lee +6 more
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An Overview of the Anatomical Distribution of Tetrodotoxin in Animals
Toxins, 2022 Tetrodotoxin (TTX), a potent paralytic sodium channel blocker, is an intriguing marine toxin. Widely distributed in nature, TTX has attracted attention in various scientific fields, from biomedical studies to environmental safety concerns. Despite a long
Daria I. Melnikova, Timur Yu. Magarlamov
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Toxins, 2021 Nemertea is a phylum of marine worms whose members bear various toxins, including tetrodotoxin (TTX) and its analogues. Despite the more than 30 years of studying TTXs in nemerteans, many questions regarding their functions and the mechanisms ensuring ...
Anna E. Vlasenko +6 more
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An Updated Review of Tetrodotoxin and Its Peculiarities
Marine Drugs, 2022 Tetrodotoxin (TTX) is a crystalline, weakly basic, colorless organic substance and is one of the most potent marine toxins known. Although TTX was first isolated from pufferfish, it has been found in numerous other marine organisms and a few terrestrial ...
Panagiota Katikou +4 more
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Marine Drugs, 2011 Puffer fish, Takifugu niphobles, collected from the Hong Kong coastal waters were screened for tetrodotoxin-producing bacteria. A Gram-negative, non-acid-fast, non-sporing and rod shaped bacterial strain (designated as gutB01) was isolated from the ...
Fred Wang-Fat Lee +3 more
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Repurposing of thermally stable nucleic-acid aptamers for targeting tetrodotoxin (TTX)
Computational and Structural Biotechnology Journal, 2022 Tetrodotoxin (TTX) is a lethal neurotoxin produced by the endosymbiotic bacteria in the gut of puffer fish. Currently, there is no effective and economical method to detect TTX, so it is very interesting to develop low-cost and high-sensitivity detection methods by using nucleic-acid aptamers as the recognition molecules.
Yuanyuan Li +5 more
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Journal of Pharmacological Sciences, 2007 One possible mechanism underlying inflammation-induced sensitization of the primary afferent neuron is the upregulation of tetrodotoxin-resistant (TTX-R) Na+ current by inflammatory mediators such as prostaglandins.
Taixing Zheng +4 more
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