The Chemical and Evolutionary Ecology of Tetrodotoxin (TTX) Toxicity in Terrestrial Vertebrates [PDF]
Marine Drugs, 2010 Tetrodotoxin (TTX) is widely distributed in marine taxa, however in terrestrial taxa it is limited to a single class of vertebrates (Amphibia). Tetrodotoxin present in the skin and eggs of TTX-bearing amphibians primarily serves as an antipredator ...
Charles T. Hanifin
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Bibliographic Studies on the Tetrodotoxin(TTX)
Journal of Pharmacopuncture, 2000 We were trying to study the validity of Puffer fish's poison(Tetrodotoxin- TTX) to make a traditional Korean Medical treatment. The following conclusions were made after literary studies. 1.
Hwang, Tae-Joon +2 more
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Repurposing of thermally stable nucleic-acid aptamers for targeting tetrodotoxin (TTX). [PDF]
Comput Struct Biotechnol J, 2022 Tetrodotoxin (TTX) is a lethal neurotoxin produced by the endosymbiotic bacteria in the gut of puffer fish. Currently, there is no effective and economical method to detect TTX, so it is very interesting to develop low-cost and high-sensitivity detection methods by using nucleic-acid aptamers as the recognition molecules.
Li Y +5 more
europepmc +4 more sources
High Levels of Tetrodotoxin (TTX) in Trumpet Shell Charonia lampas from the Portuguese Coast. [PDF]
Toxins (Basel), 2021 Tetrodotoxin (TTX) is a potent neurotoxin, considered an emerging toxin in Europe where recently a safety limit of 44 µg TTX kg−1 was recommended by authorities. In this study, three specimens of the large gastropod trumpet shell Charonia lampas bought in a market in south Portugal were analyzed using a neuroblastoma cell (N2a) based assay and by LC-MS/
Costa PR +6 more
europepmc +7 more sources
6-Nitrodopamine Potentiates Catecholamine-Induced Ca<sup>2+</sup> <sub>i</sub> Release in Human Aortic Smooth Muscle and Modulates Vascular Smooth Muscle Contractility. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Background In vascular smooth muscle, rises in intracellular calcium [Ca2+]i drive contraction downstream of α1‐adrenoceptor activation via IP3. Endothelium‐derived 6‐nitrodopamine (6‐ND) augments cardiac catecholamine actions; however, its effect on [Ca2+]i is unknown.
Britto-Júnior J +7 more
europepmc +2 more sources
The impact of tetrodotoxin (TTX) on the gut microbiome in juvenile tiger pufferfish, Takifugu rubripes. [PDF]
Sci RepAbstractTetrodotoxin (TTX) is a potent neurotoxin that accumulates in Takifugu rubripes, commonly known as pufferfish, through the ingestion of TTX-bearing organisms as part of their food chain. Although researchers believe that pufferfish use TTX to relieve stress, data are not currently available on how TTX affects the gut microbiota of pufferfish ...
Wassel MA +5 more
europepmc +4 more sources
Alternative Pathways of Acetylcholine Release in the Colon: Role of High-Affinity Choline Transporters. [PDF]
Neurogastroenterol MotilMechanisms of Acetylcholine release, including typical and atypical release under neuronal blockade. Left panel illustrates the classical (quantal) cholinergic transmission and the right panel the mechanism described in the present study. High‐Affinity Choline Transporter (HCT), Acetylcholine (ACh), Acetylcholinesterase (ACE), and Tetrodotoxin (TTX ...
Martinez-Daunis A +4 more
europepmc +2 more sources
Antinociceptive effects of tetrodotoxin (TTX) in rodents [PDF]
British Journal of Anaesthesia, 2006 Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish. The analgesic effects of TTX were investigated in different animal pain models.Wistar rats were submitted to the formalin test and to partial ligation of the sciatic nerve (Seltzer's model). Swiss Webster mice were used in the writhing test.
J, Marcil +5 more
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From Poison to Promise: The Evolution of Tetrodotoxin and Its Potential as a Therapeutic
Toxins, 2021 Tetrodotoxin (TTX) is a potent neurotoxin that was first identified in pufferfish but has since been isolated from an array of taxa that host TTX-producing bacteria.
Gary M. Bucciarelli +5 more
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A Progress on the Application of Tetrodotoxin [PDF]
E3S Web of Conferences, 2021 Tetrodotoxin (TTX), a blocker of sodium channels, exists in the pufferfish, amphibians, and octopus, and originated in endosymbiont-vibrio. Researches have confirmed that TTX affected the action potential through the regulation of voltage-gated sodium ...
Wang Zhaojia, Zhou Zhenning
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