Results 61 to 70 of about 48,663 (220)
Journal of Biological Chemistry, 2002 We have isolated a highly potent neurotoxin from the venom of the Chinese bird spider, Selenocosmia huwena. This 4.1-kDa toxin, which has been named huwentoxin-IV, contains 35 residues with three disulfide bridges: Cys-2–Cys-17, Cys-9–Cys-24, and Cys-16 ...
K. Peng, Q. Shu, Zhonghua Liu, S. Liang
semanticscholar +1 more source
The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth +7 more
wiley +1 more source
Marine Drugs, 2022 Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent with changes in ...
Shana L. Geffeney +3 more
doaj +1 more source
Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?
Toxins, 2021 Tetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically classified as TTX-sensitive or TTX-resistant channels.
R. González-Cano +5 more
semanticscholar +1 more source
New insights into epileptic spasm generation and treatment from the TTX animal model
Epilepsia Open, EarlyView.Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann +2 more
wiley +1 more source
Marine Drugs, 2006 : Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms.
C. Ruben, Shana L. Geffeney
doaj +1 more source
Genetic structure of Pleurobranchaea maculata in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Genetics, The New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand [PDF]
, 2016 The grey side-gilled sea slug (Pleurobranchaea maculata), which is native to the western and south Pacific, is known to contain high concentrations of tetrodotoxin (TTX). P. maculata populations around New Zealand exhibit individual, spatial and temporal
Yildirim, Yeşerin
core
SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. [PDF]
, 2016 The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule ...
Goldstein, Steve An +2 more
core +2 more sources
The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source
Optical mapping of neuronal activity during seizures in zebrafish [PDF]
, 2017 Mapping neuronal activity during the onset and propagation of epileptic seizures can provide a better understanding of the mechanisms underlying this pathology and improve our approaches to the development of new drugs.
Fornetto, C +10 more
core +3 more sources