Results 81 to 90 of about 17,066 (197)

GLP‐1 Receptors Are Enriched in the Lymphatic Endothelium and Their Pharmacological Activation With Semaglutide Improves the Pumping Capacity of Lymphatic Vessels

Microcirculation, Volume 33, Issue 5, July 2026.
ABSTRACT Objectives Recent clinical studies have suggested that glucagon‐like peptide‐1 receptor (GLP‐1R) agonists may be effective therapies to treat or reduce the risk of developing secondary lymphedema. In this study, we aimed to (1) determine if GLP‐1Rs are present in the lymphatic vasculature and characterize their expression, and (2) assess the ...
Mary E. Schulz, Victoria L. Akerstrom, Joseph H. Dayan, Jorge A. Castorena‐Gonzalez   +3 more
wiley   +1 more source

Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex

The Journal of Physiology, Volume 604, Issue 14, Page 6057-6079, 15 July 2026.
Abstract figure legend The lateral hypothalamus (LH) is a critical controller of innate behaviours such as feeding. It is anatomically connected to specific cortical areas. We mapped these areas using a combination of retrograde tracing and anterograde optogenetic circuit mapping.
Lotte J. A. M. Razenberg, Pieter Nicolaas de Greef, Huibert D. Mansvelder, Mahesh Miikael Karnani   +3 more
wiley   +1 more source

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

Marine Drugs, 2019
Voltage-gated sodium channels (NaVs) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) NaV subtype with saxitoxin (STX),
Kanna Adachi, Hayate Ishizuka, Minami Odagi, Kazuo Nagasawa   +3 more
doaj   +1 more source

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Toxins, 2014
Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan.
Vaishali Bane, Mary Lehane, Madhurima Dikshit, Alan O'Riordan, Ambrose Furey   +4 more
doaj   +1 more source

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Toxins, 2017
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal, M. Carmen Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +7 more
doaj   +1 more source

Evolutionary Genetics of Tetrodotoxin (TTX) Resistance in Snakes: Tracking a Feeding Adaptation from Populations Through Clades

, 2021
Chris R. Feldman
openalex   +2 more sources

Tetrodotoxin‐resistant mechanosensitivity and L‐type calcium channel‐mediated spontaneous calcium activity in enteric neurons

Experimental Physiology
Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell ...
Richard J. Amedzrovi Agbesi, Amira El Merhie, Nick J. Spencer, Tim Hibberd, Nicolas R. Chevalier   +4 more
doaj   +1 more source

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

Toxins, 2018
Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang, Chengcheng Han, Si Chen, Le Li, Jingjing Zong, Junjie Zeng, Guangming Mei   +6 more
doaj   +1 more source

4-Aminopyridine Reverses Saxitoxin (STX)- and Tetrodotoxin (TTX)-Induced Cardiorespiratory Depression in Chronically Instrumented Guinea Pigs [PDF]

, 1997
Fat-Chun T. Chang, David L. Spriggs, Bernard J. Benton, Shannon A. Keller, Benedict R. Capacio   +4 more
openalex   +1 more source

Mixture effects of tetrodotoxin (TTX) and drugs targeting voltage-gated sodium channels on spontaneous neuronal activity in vitro

, 2022
Anke M. Tukker, Misha F. Vrolijk, Regina G.D.M. van Kleef, Dick T.H.M. Sijm, Remco H.S. Westerink   +4 more
openalex   +1 more source