Results 81 to 90 of about 27,116 (203)

Tetrodotoxin-resistant sodium channels in neuropathic pain

, 2000
Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury.
Jenny Fjell Hjelmström (19527955)
core   +1 more source

Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current

Marine Drugs, 2011
Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved.
Jaakko Haverinen, Minna Hassinen, Matti Vornanen   +2 more
doaj   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Toxic mechanism and detection methods of tetrodotoxin [PDF]

MATEC Web of Conferences
Tetrodotoxin (TTX) was first isolated in the early 20th century and has significant public health implications, especially in areas where puffer fish are consumed, such as Japan.
Xu Yunzhe
doaj   +1 more source

Tetrodotoxin and Its Analogues in Cephalothrix cf. simula (Nemertea: Palaeonemertea) from the Sea of Japan (Peter the Great Gulf): Intrabody Distribution and Secretions

Toxins, 2020
Some nemertean species from the genus Cephalothrix accumulate tetrodotoxin (TTX) in extremely high concentrations. The current study is the first to provide high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) data on tetrodotoxin
Anna E. Vlasenko, Timur Yu. Magarlamov
doaj   +1 more source

Puffer smells tetrodotoxin [PDF]

, 2013
Behavioral observation was conducted to test whether olfaction is functional to detect tetrodotoxin (TTX) in tiger puffer Takifugu rubripes using Y-maze. We placed either agarose carrier or one agarose and one agarose containing TTX (200 MU) at each head
Okita, Kogen, Arakawa, Osamu, Sakakura, Yoshitaka, Takatani, Tomohiro, Yamazaki, Hideki, Yamane, Hikaru, Sakiyama, Kazutaka, Niina, Shinya   +7 more
core   +1 more source

The Expression of Neuropeptides in Pulpitis: A Systematic Review and Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Background Neuropeptides play key roles in the inflammatory, nociceptive and reparative processes of the dental pulp. Their upregulation has been frequently observed in inflamed pulps, suggesting potential diagnostic value supporting a role for neurogenic inflammation in symptomatic irreversible pulpitis.
N. Watson, D. Edwards, Q. Vuong, I. Obara   +3 more
wiley   +1 more source

The Microbial Community of Tetrodotoxin-Bearing and Non-Tetrodotoxin-Bearing Ribbon Worms (Nemertea) from the Sea of Japan

Marine Drugs, 2020
A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora
Daria I. Melnikova, Timur Yu. Magarlamov   +1 more
doaj   +1 more source

Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes [PDF]

, 2017
Tetrodotoxin (TTX) is an extremely toxic marine neurotoxin. TTX inhibits voltage-gated sodium channels, resulting in a potentially lethal inhibition of neurotransmission.
Sub IRAS Tox CMT/NTX, dIRAS RA-1, Westerink, Remco H S, Emma E.J. Kasteel, Remco H.S. Westerink, LS IRAS Tox CMT/ATX, Kasteel, Emma E J   +6 more
core   +1 more source

Distinct electrophysiology and dopaminergic modulation of medium spiny neurons across divisions of the tail striatum and the dorsolateral striatum

Experimental Physiology, EarlyView.
Abstract The striatum is a brain region within the basal ganglia that plays a crucial role in generating behaviour and mediating perception. The tail striatum (TS) is a poorly understood striatal domain with predominantly sensory functions. Recent evidence supports that abnormal TS dopamine transmission in dopaminergic disease contributes to sensory ...
Bronwyn Riley, Luke E. Hallum, Srdjan M. Vlajkovic, Johanna M. Montgomery, Peter S. Freestone   +4 more
wiley   +1 more source