Results 51 to 60 of about 5,684 (129)

miR‐214‐3p and NCKAP1: A microglial functional dimension of Alzheimer's progression

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Biological Alzheimer's disease (AD) pathology does not fully explain the marked heterogeneity in clinical severity or progression. We investigated whether patient‐derived induced microglia‐like cell (iMG) profiles capture a functional dimension of AD progression beyond conventional plasma biomarkers.
Min‐Young Noh, Yeonsil Moon, Sungwoo Kang, Won‐Jin Moon, Hee‐Jin Kim, Sang Won Seo, Sugyeong Ahn, Mi‐Hyeon Kang, Yong Sung Kim, Hyunkee Kim, Jae‐sung Bae, Hee Kyung Jin, Hojin Choi, Seong‐Ho Koh, Kee Hyung Park, Gregory S. Day, Guojun Bu, Seung Hyun Kim   +17 more
wiley   +1 more source

Transcriptionally up-regulation of CDKN1A/p21 by TFE3 fusion proteins worsened TFE3-rearranged renal cell carcinoma

Scientific Reports
The TFE3-rearranged renal cell carcinoma (TFE3-rRCC), which is an uncommon and aggressive form of kidney cancer, has an unfavorable prognosis. It has been shown that CDKN1A/p21 is high-expressed in TFE3-rRCC, however, the exact mechanism and the role of ...
Yanwen Lu, Wenliang Ma, Yi Chen, Xiang Dong, Xinghe Pan, Lei Yang, Shuoming Zhou, Ning Liu, Dongmei Li, Weidong Gan   +9 more
doaj   +1 more source

A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38

Redox Biology, 2020
TFEB (transcription factor EB) and TFE3 (transcription factor E3) are “master regulators” of autophagy and lysosomal biogenesis. The stress response p38 mitogen-activated protein (MAP) kinases affect multiple intracellular responses including ...
Chuanbin Yang, Zhou Zhu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Jian Xie, Yu Zhu, Sravan Gopalkrishnashetty Sreenivasmurthy, Krishnamoorthi Senthilkumar, King-Ho Cheung, Ju-Xian Song, Hong-Jie Zhang, Min Li   +11 more
doaj   +1 more source

Pathology‐Driven Diagnosis of Hereditary Leiomyomatosis and Renal Cell Carcinoma: A Clinicopathological and Genetic Analysis of Three Cases

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant disorder characterized by three principal clinical features: cutaneous leiomyomas (cLMs), uterine leiomyomas, and fumarate hydratase (FH)‐deficient renal cell carcinoma (RCC).
Tomoko Uchiyama, Shunsuke Okazaki, Sayaka Ando, Maiko Takeda, Makito Miyake, Akihiko Yoshizawa   +5 more
wiley   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Advances in research on autophagy in the maintenance of insect–microbe symbiosis

New Plant Protection, Volume 3, Issue 3, September 2026.
Autophagy plays a dual regulatory role in insect–microbe symbiotic relationships. Beneficial symbiotic bacteria in insects participate in nutrient exchange via the TOR pathway, whereas pathogenic microbes induce immune defense through the AMPK pathway. Autophagy‐related genes regulate development and pathogen clearance during this process.
Yanbin Wang, Yuqiong Hao, Ke Chen, Hongbin Zhang, Xiansheng Xie, Feirong Ren   +5 more
wiley   +1 more source

Painful Purplish Lesion on the Right Lower Lip Mucosa

Oral Diseases, EarlyView.
Isabella Cristine Pegolo Dos Santos Alamino, Hilton M. A. Hicz, Alan Grupioni Lourenço, Joel D. B. Padua, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini   +5 more
wiley   +1 more source

Novel Postzygotic Variants Associated With Hypomelanosis of Ito Expand the ACTB‐Related Neurocutaneous Disease Spectrum

Clinical Genetics, Volume 110, Issue 3, Page 369-373, September 2026.
We describe a previously unreported phenotype related to postzygotic ACTB variants with hypomelanosis of Ito, characterized by hypopigmentation associated or not with neurodevelopmental features, distinct from Becker presentations, bridging constitutional neurodevelopmental and somatic cutaneous phenotypes.
Estella Castillon, Paul Rollier, Didier Bessis, Laurent Pasquier, Caroline Racine, Alexis Praga, Pierre Vabres, Bertille Bonniaud, Paul Kuentz, Laurence Faivre   +9 more
wiley   +1 more source

C-terminal fusion partner activity contributes to the oncogenic functions of YAP1::TFE3

Scientific Reports
YAP1 gene fusions are found in a multitude of human tumors and are the likely tumor-initiating events in these tumors. We have previously shown that YAP1 fusion proteins exert TEAD-dependent oncogenic YAP1 activity.
Patrick J Cimino, Dylan J Keiser, Abigail G Parrish, Eric C Holland, Frank Szulzewsky   +4 more
doaj   +1 more source

Differential contribution of TFE3 isoforms to cell motility and invasion

EMBO Reports
TFE3 orchestrates cellular responses to a variety of stress conditions, promoting restoration of cellular homeostasis and cell survival. Here we report the presence of two different TFE3 isoforms generated by the use of alternative transcription ...
Pablo S Contreras, José A Martina, Katie Rollins, Eutteum Jeong, Alberto Rissone, Rosa Puertollano   +5 more
doaj   +1 more source