Results 61 to 70 of about 5,684 (129)

TFE3 fusion proteins promote the progression of TFE3 rearranged renal cell carcinoma via enhancing chaperone-mediated lipophagy

Cell Communication and Signaling
Background TFE3 rearranged renal cell carcinoma (TFE3 rRCC), classified as a distinct entity of RCCs, exhibits aggressive biological behavior and possesses unique metabolic characteristics.
Wenliang Ma, Yi Chen, Guijuan Chen, Lei Yang, Yanwen Lu, Xiang Dong, Dongmei Li, Weidong Gan   +7 more
doaj   +1 more source

A radiomics-based interpretable model to distinguish Xp11.2/TFE3 translocation renal cell carcinoma and common types of renal cell carcinoma on CT images

Cancer Treatment and Research Communications
Background: TFE3-RCC is rare, hard to distinguish from common RCC on CT, posing preoperative diagnostic challenges for clinicians.This two-center study aimed to develop interpretable machine learning models using radiomics to differentiate Xp11.2/TFE3 ...
Yi Liu, Qi Shen, Kexin Wang, Yaofeng Zhang, Jiangtao Liu, Jianxing Qiu, Xiaoying Wang   +6 more
doaj   +1 more source

NUPR1 contributes to activate TFE3-dependent autophagy leading to cervical cancer proliferation

Heliyon
Cervical cancer is a malignant tumor that occurs in the cervix of women and endangers their lives. In this study, we aimed to assess the roles of NUPR1 and TFE3 in cervical cancer.
Xiaoguang Wang, Ke Wang, Xiuli Wang
doaj   +1 more source

SFPQ-TFE3 reciprocally regulates mTORC1 and induces lineage plasticity in a mouse model of renal tumorigenesis

Nature Communications
MiT/TFE gene fusions like SFPQ-TFE3 drive both epithelial (translocation RCC) and mesenchymal (PEComas) neoplasms. However, no mouse models for SFPQ-TFE3-related tumors exist and the underlying mechanisms of lineage plasticity remain unclear.
Kaushal Asrani, Adrianna Amaral, Juhyung Woo, Sanaz Nourmohammadi Abadchi, Thiago Vidotto, Eddie Imada, Alyza Skaist, Kewen Feng, Hans B. Liu, Mithila Kasbe, Yorifumi Satou, Masaya Baba, Yuichi Oike, Patricia Outeda, Terry Watnick, Avi Z. Rosenberg, Laura S. Schmidt, W. Marston Linehan, Pedram Argani, Tamara L. Lotan   +19 more
doaj   +1 more source

TFE3-mediated neuroprotection: Clearance of aggregated α-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease

Genes and Diseases
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar neuronal inclusions containing aggregated α-synuclein (α-Syn). While the pathology of PD is multifaceted, the aggregation of α-Syn and mitochondrial dysfunction are well ...
Xin He, Mulan Chen, Yepeng Fan, Bin Wu, Zhifang Dong   +4 more
doaj   +1 more source

Contrast-enhanced ultrasound findings of adult renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma

Cancer Imaging, 2019
Background To investigate the contrast-enhanced ultrasound (CEUS) findings of renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2/TFE3) in adult patients by comparison with those of clear cell RCC (ccRCC) and ...
Shuping Wei, Fuli Tian, Qiuyuan Xia, Pengfei Huang, Yidan Zhang, Zhichao Xia, Min Wu, Bin Yang   +7 more
doaj   +1 more source

Patients with ASPSCR1-TFE3 fusion achieve better response to ICI based combination therapy among TFE3-rearranged renal cell carcinoma

Molecular Cancer
Background TFE3-rearranged renal cell carcinoma (TFE3-rRCC) is a rare but highly heterogeneous renal cell carcinoma (RCC) entity, of which the clinical treatment landscape is largely undefined.
Junjie Zhao, Yanfeng Tang, Xu Hu, Xiaoxue Yin, Yuntian Chen, Junru Chen, Haoyang Liu, Haolin Liu, Jiayu Liang, Xingming Zhang, Jinge Zhao, Sha Zhu, Yuchao Ni, Zhipeng Wang, Jindong Dai, Zilin Wang, Yaowen Zhang, Jin Yao, Ni Chen, Pengfei Shen, Zhenhua H. Liu, Hao Zeng, Guangxi X. Sun   +22 more
doaj   +1 more source

A nomogram based on TFE3 IHC results and clinical factors as a preliminary screening scheme for TFE3‐rearranged renal cell carcinoma

Cancer Medicine
Background TFE3 immunohistochemistry (TFE3‐IHC) is controversial in the diagnosis of TFE3‐rearranged renal cell carcinoma (TFE3‐rearranged RCC). This study is to investigate the accuracy and sensitivity of IHC and establish a predictive model to diagnose
Pengju Li, Quanhui Xu, Minyu Chen, Jiangquan Zhu, Yinghan Wang, Mukhtar A. Mumin, Kangbo Huang, Zeying Jiang, Hui Liang, Qiong Deng, Zhu Wang, Bing Liao, Wenfang Chen, Yun Cao, Jiazheng Cao, Junhang Luo   +15 more
doaj   +1 more source

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

Nature Communications
The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCCs), frustrating efforts to identify therapeutic
Amir Pozner, Li Li, Shiv Prakash Verma, Shuxin Wang, Jared J. Barrott, Mary L. Nelson, Jamie S. E. Yu, Gian Luca Negri, Shane Colborne, Christopher S. Hughes, Ju-Fen Zhu, Sydney L. Lambert, Lara S. Carroll, Kyllie Smith-Fry, Michael G. Stewart, Sarmishta Kannan, Bodrie Jensen, Cini M. John, Saif Sikdar, Hongrui Liu, Ngoc Ha Dang, Jennifer Bourdage, Jinxiu Li, Jeffery M. Vahrenkamp, Katelyn L. Mortenson, John S. Groundland, Rosanna Wustrack, Donna L. Senger, Franz J. Zemp, Douglas J. Mahoney, Jason Gertz, Xiaoyang Zhang, Alexander J. Lazar, Martin Hirst, Gregg B. Morin, Torsten O. Nielsen, Peter S. Shen, Kevin B. Jones   +37 more
doaj   +1 more source

mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation. [PDF]

Sci Adv
Zaufel A, Sun W, Pastore N, Taschler U, Wagner C, Hackl H, Sommer J, Silbert-Wagner D, Hengstler JG, Begher-Tibbe B, Stauber R, Kolb D, Troetzmueller M, Gottschalk B, Thorsheim C, Stange EL, Hornef MW, Pivovarova-Ramich O, Pfeiffer AFH, Matchett KP, Loft A, Herzig S, Henderson NC, Ballabio A, Arany Z, Wolfrum C, Fickert P, Moustafa T.   +27 more
europepmc   +1 more source