Results 21 to 30 of about 8,934 (195)

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines. [PDF]

Andrology
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Aksglaede L, Kanakis G, Rajpert-De Meyts E, Jezek D, Algaba F, Dohle G, Slowikowska-Hilczer J, Kliesch S, Behre HM, Krausz C, Goulis DG, Jørgensen N.   +11 more
europepmc   +2 more sources

Residence Near Agricultural Crops at Birth and Risk of Adult Testicular Germ Cell Tumors: A French Nationwide Case-Control Study Using Historical Aerial GIS Data. [PDF]

Int J Cancer
As the incidence of testicular germ cell tumors (TGCTs) rises, prenatal exposure to agricultural pesticides may represent an important risk factor. Here, geographic information system‐based measures of farmland proximity at birth were used as a proxy for early‐life pesticide exposure in France, a major pesticide consumer.
Danjou AMN, Coste A, Grassot L, Faure E, Crispim-Junior C, Tougne Rodet L, Pérol O, Béranger R, Perrin J, Charbotel B, Schüz J, Fervers B, TESTIS study group.   +12 more
europepmc   +2 more sources

In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis

Disease Markers, 2020
Testicular germ cell tumors (TGCTs) are ever more affecting the young male population. Germ cell neoplasia in situ (GCNIS) is the origin of TGCTs, namely, seminomas (SE) and a heterogeneous group of nonseminomas (NS) comprising embryonal carcinoma, teratoma, yolk sac tumor, and choriocarcinoma. Response to the treatment and prognosis, especially of NS,
Dora Raos, Jure Krasic, Silvija Masic, Irena Abramovic, Marijana Coric, Bozo Kruslin, Ana Katusic Bojanac, Floriana Bulic-Jakus, Davor Jezek, Monika Ulamec, Nino Sincic   +10 more
openaire   +2 more sources

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. [PDF]

, 2013
Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported.
Robert A Huddart, Sheila Seal, Eeles, Rosalind, Kote-Jarai, Zsofia, Elliot, Anna, Ruark, E, McDonald, Heather, Peto, Julian, D Timothy Bishop, Muir, K; id_orcid, Stratton, Michael R, Seal, Sheila, Turnbull, Clare, Kote-Jarai, Z, Muir, Kenneth (Kenneth R.), Kenneth Muir, Perdeaux, Elizabeth, Easton, Douglas F, McDonald, H, Zhang, Feng, Easton, Douglas F., Elizabeth Rapley, Muir, K, Seal, S, Janet Shipley, Perdeaux, E, Stratton, MR, Feng Zhang, KingWai Lau, Rahman, N, Huddart, RA, Bishop, DT, Rapley, Elizabeth, Rosalind Eeles, Stratton, Michael R., Huddart, Robert A, Heather McDonald, Huddart, R A, Nazneen Rahman, Muir, Kenneth, Elise Ruark, Shipley, Janet, McDonald, H. (Heather), UK Testicular Cancer Collaboration (UKTCC), Michael R Stratton, Anna Elliot, Nsengimana, J, Eeles, R, Jeremie Nsengimana, Elliot, A, Douglas F Easton, Shipley, J, UK Testicular Cancer Collaboration (UKTCC),, Turnbull, C, Elizabeth Perdeaux, Zsofia Kote-Jarai, Rapley, E. (Elizabeth), Bishop, D. Timothy (David Timothy), Clare Turnbull, Peto, J, Stratton, M R, Lau, Kingwai, Lau, K, Nsengimana, Jeremie, Ruark, Elise, Bishop, D Timothy, Easton, DF, Zhang, F, Rahman, Nazneen, Easton, D F, Rapley, E, Julian Peto, Bishop, D T, Huddart, Robert A.   +73 more
core   +1 more source

A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor

Frontiers in Oncology, 2022
Patients who develop testicular germ cell tumours (TGCT) are at higher risk to be subfertile than the general population. The conditions are believed to originate during foetal life, however, the mechanisms behind a common aetiology of TGCT and male ...
Joshua Burton, Marcin W. Wojewodzic, Marcin W. Wojewodzic, Trine B. Rounge, Trine B. Rounge, Trine B. Haugen   +5 more
doaj   +1 more source

Clinical and genetic aspects of testicular germ cell tumours

Hereditary Cancer in Clinical Practice, 2008
In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 15-40 years. Its incidence has increased sharply in recent years.
Holzik Martijn, Sijmons Rolf H, Hoekstra-Weebers Josette EHM, Sleijfer Dirk T, Hoekstra Harald J   +4 more
doaj   +1 more source

Cryptorchidism and Testicular Tumor: Comprehensive Analysis of Common Clinical Features and Search of SNVs in the KIT and AR Genes

Frontiers in Cell and Developmental Biology, 2020
Allelic variants in genes implicated in the development of testicular germ cell tumor (TGCT) could be present in patients with cryptorchidism (CO). Currently; the mechanisms explaining this relationship are still unknown.
Daniel Adrian Landero-Huerta, Daniel Adrian Landero-Huerta, Rosa María Vigueras-Villaseñor, Emiy Yokoyama-Rebollar, Fabiola García-Andrade, Julio César Rojas-Castañeda, Luis Alonso Herrera-Montalvo, Luis Alonso Herrera-Montalvo, José Díaz-Chávez, Isidro Xavier Pérez-Añorve, Elena Aréchaga-Ocampo, Margarita Dolores Chávez-Saldaña   +11 more
doaj   +1 more source

Identification of mRNA Prognostic Markers for TGCT by Integration of Co-Expression and CeRNA Network [PDF]

Frontiers in Endocrinology, 2021
Testicular germ cell tumor (TGCT) is the most common malignant tumor in young men and is associated with poor prognosis. We assessed the RNA expression profiles of 13 TGCT tissues and 4 adjacent normal tissues by transcriptome sequencing to identify novel prognostic biomarkers.
Fang Zhu, Zhizhong Liu, Zhizhong Liu, Qianyin Zhou, Jingyu Fan, Dai Zhou, Dai Zhou, Liu Xing, Hao Bo, Hao Bo, Le Tang, Liqing Fan, Liqing Fan   +12 more
openaire   +3 more sources

Table_2_Identification of mRNA Prognostic Markers for TGCT by Integration of Co-Expression and CeRNA Network.xlsx

, 2021
Testicular germ cell tumor (TGCT) is the most common malignant tumor in young men and is associated with poor prognosis. We assessed the RNA expression profiles of 13 TGCT tissues and 4 adjacent normal tissues by transcriptome sequencing to identify ...
Zhizhong Liu (157561), Jingyu Fan (4517959), Liu Xing (11240091), Liqing Fan (5684831), Dai Zhou (11240082), Fang Zhu (185566), Hao Bo (5863877), Qianyin Zhou (11461714), Le Tang (618285)   +8 more
core   +1 more source

Incidence of Gonadal and Extragonadal Germ Cell Tumours in Patients With Klinefelter Syndrome. [PDF]

Andrology
ABSTRACT Background Klinefelter's syndrome (KS; 47, XXY) is associated with an altered risk profile for malignancies compared with non‐KS males. In particular, several reports have noted a striking association between KS and extragonadal germ cell tumours (EGCTs), especially in the mediastinum, whereas the risk of testicular germ cell tumours (TGCTs ...
Tailor A, Bandyopadhyay O, Ahmed N, Shanmugathasan K, Cotton A, Chen C, Yap T.   +6 more
europepmc   +2 more sources