Results 51 to 60 of about 8,934 (195)

The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Peter A. Kanetsky, Kristian Almstrup, Svetlana Cherlin, Victoria K. Cortessis, Alberto Ferlin, Jourik A. Gietema, Anna González‐Neira, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Lambertus A. Kiemeney, Jung Kim, Csilla Krausz, Davor Lessel, Ragnhild A. Lothe, Kevin T. Nead, Jérémie Nsengimana, Jenny N. Poynter, Ewa Rajpert‐DeMeyts, Lorenzo Richiardi, Stephen M. Schwartz, Rolf I. Skotheim, Douglas R. Stewart, Clare Turnbull, Fredrik Wiklund, Tongzhang Zheng, Katherine L. Nathanson, Katherine A. McGlynn, for the Testicular Cancer Consortium   +28 more
wiley   +1 more source

Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors

Frontiers in Oncology
Tendon Sheath Giant Cell Tumor (TGCT) is a benign tumor that primarily grows within joints and bursae. However, it has a high postoperative recurrence rate, ranging from 15% to 45%. Although radiotherapy may reduce this recurrence rate, its applicability
Tianwei Zhang, Bin Zeng, Ke Liu, Qin Zeng, Na Wang, Ling Peng, Hongbo Qiu, Xiaomei Chen, Lin Wang   +8 more
doaj   +1 more source

The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases

Diagnostic Pathology, 2020
Background Molecular diagnostics can be decisive in the differential diagnosis between a somatic metastasis of type II testicular germ cell tumor (TGCT) or a second primary carcinoma.
Mariëtte E. G. Kranendonk, Wenzel M. Hackeng, G. Johan A. Offerhaus, Folkert H. M. Morsink, Geertruida N. Jonges, Gerard Groenewegen, Pieter-Jaap Krijtenburg, Heinz-Josef Klümpen, Wendy W. J. de Leng, Leendert H. J. Looijenga, Lodewijk A. A. Brosens   +10 more
doaj   +1 more source

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches

, 2022
Introduction Tenosynovial giant cell tumor (TGCT) is a mono-articular, benign or locally aggressive and often debilitating neoplasm. Systemic therapies are becoming part of the multimodal armamentarium when surgery alone will not confer improvements ...
Gelderblom, H., Heijden, L. van der, Langevelde, K. van, Sande, M.A.J. van de, Spierenburg, G., Szuhai, K., Bovee, J.V.G.M.   +6 more
core   +1 more source

Fine needle aspiration cytology diagnosis of metastatic malignant diffuse type tenosynovial giant cell tumor

Journal of Cytology, 2017
Tenosynovial giant cell tumors (TGCTs) arise from the synovium of joint, bursa, and tendon sheath, and are classified into localized and diffuse types.
Prashant Ramteke, Venkat K Iyer, Karan Madan, Shivanand Gamangatti, Asit R Mridha   +4 more
doaj   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

ENLIVEN study: Pexidartinib for tenosynovial giant cell tumor (TGCT)

Future Oncology, 2020
Pexidartinib is the first approved medication in the USA for people with tenosynovial giant cell tumor (TGCT). The drug was approved based on the ENLIVEN study, which looked at pexidartinib (brand name, Turalio™), a medication taken by mouth (orally) for people with TGCT (also known as giant cell tumor of the tendon sheath [GCTTS] and pigmented ...
openaire   +2 more sources

Networks of pre-diagnostic circulating RNA in testicular germ cell tumour

Scientific Reports
Testicular germ cell tumour (TGCT) is a malignancy with known inherited risk factors, affecting young men. We have previously identified several hundred differentially abundant circulating RNAs in pre-diagnostic serum from TGCT cases compared to healthy ...
Joshua Burton, Trine B. Rounge, Trine B. Haugen, Marcin W. Wojewodzic   +3 more
doaj   +1 more source

Somatic mutation detection and KRAS amplification in testicular germ cell tumors

Frontiers in Oncology, 2023
BackgroundTesticular Germ Cell Tumors (TGCT) are the most common cancer among young adult men. The TGCT histopathology is diverse, and the frequency of genomic alterations, along with their prognostic role, remains largely unexplored. Herein, we evaluate
Eduardo R. M. Cabral, Marilia F. Pacanhella, Andre V. H. Lengert, Mariana B. dos Reis, Leticia F. Leal, Leticia F. Leal, Marcos A. de Lima, Aline L. V. da Silva, Icaro A. Pinto, Rui M. Reis, Rui M. Reis, Rui M. Reis, Mariana T. Pinto, Flavio M. Cárcano, Flavio M. Cárcano   +14 more
doaj   +1 more source