Results 71 to 80 of about 8,934 (195)

Parallel Liquid Biopsy Analysis of miR‐371a‐3p and Cell‐Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova, Romy Kralova, Eva Parobkova, Violeta Bakardjieva‐Mihaylova, Martina Zwyrtkova, Karolina Skvarova Kramarzova, Ludmila Boublikova   +6 more
wiley   +1 more source

Androgens Modulate Tumor–Immune Interactions in Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The majority of testicular germ cell tumors (TGCT) are derived from the germ cell neoplasia in situ and arise after puberty in the local presence of high levels of testosterone. The seminoma subtype features a rich inflammatory infiltrate which impacts tumor progression but the role of testosterone in shaping tumor–immune ...
Ida Hamann, Lucas Klaus, Patrick Fruth, Alexander Fichtner, Tobias J. Legler, Holger M. Reichardt, Fabian A. Gayer   +6 more
wiley   +1 more source

Serum RNA Profiling in the 10-Years Period Prior to Diagnosis of Testicular Germ Cell Tumor

Frontiers in Oncology, 2020
Although testicular germ cell tumor (TGCT) overall is highly curable, patients may experience late effects after treatment. An increased understanding of the mechanisms behind the development of TGCT may pave the way for better outcome for patients.
Joshua Burton, Sinan U. Umu, Hilde Langseth, Tom Grotmol, Tom K. Grimsrud, Trine B. Haugen, Trine B. Rounge, Trine B. Rounge   +7 more
doaj   +1 more source

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

Cancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu, Xinhui Lv, Shunhao Zhang, Yafang Chen, Sicong Liu, Feiyang Song, Chunmei Zhao, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

sj-xlsx-1-tam-10.1177_17588359221090365 – Supplemental material for The utility of cfDNA in TGCT patient management: a systematic review

, 2022
Supplemental material, sj-xlsx-1-tam-10.1177_17588359221090365 for The utility of cfDNA in TGCT patient management: a systematic review by Jure Krasic, Lucija Skara, Ana Katusic Bojanac, Monika Ulamec, Davor Jezek, Tomislav Kulis and Nino Sincic in ...
Ana Katusic Bojanac (12649381), Monika Ulamec (12649384), Jure Krasic (12649375), Lucija Skara (12649378), Nino Sincic (12649393), Davor Jezek (12649387), Tomislav Kulis (12649390)   +6 more
core   +1 more source

Trends in testicular germ cell tumors among native black African men do not mirror those of African Americans: multi-institutional data from South Africa

African Journal of Urology, 2021
Background Testicular germ cell tumor (TGCT) is most frequently diagnosed in young males and its etiology remains poorly understood. Cases of newly diagnosed TGCT have been rising in the United States and incidence among African Americans (AA) has ...
Farzana Cassim, Amy Pearlman, Ethan Matz, Ryan Terlecki, Andre van der Merwe, John Lazarus, Cecelia Lloyd, Bhavish Kowlessur   +7 more
doaj   +1 more source

Circumscription of three new taxa of Merismopedia‐like Cyanobacteria shows how far convergent evolution can go

Journal of Phycology, EarlyView.
Abstract The genus Merismopedia (Merismopediaceae, Chroococcales), characterized by rectangular colonies with cells arranged in regular perpendicular rows and columns, represents a challenging study system due to its limited cultivability. The genus recently underwent taxonomic revision using cultivation‐independent techniques and a polyphasic approach.
Jan Pokorný, Jan Kaštovský, Lenka Marešová Štenclová   +2 more
wiley   +1 more source

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, Volume 159, Issue 9, Page 2290-2299, 1 November 2026.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source

Abstract 2263: Neonatal hormone levels and risk of testicular germ cell tumors (TGCT)

, 2017
Testicular germ cell tumors (TGCT) are the most commonly occurring cancers in adolescent and young adult males in the U.S. Steroid sex hormones play a central role in the development of the testis.
Libby Morimoto, Joseph Wiemels, David Zava, Xiaomei Ma, Catherine Metayer, Katherine McGlynn, Frank Stanczyk   +6 more
core   +1 more source

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science
Diffuse‐type tenosynovial giant cell tumor (D‐TGCT) and localized‐type tenosynovial giant cell tumor (L‐TGCT) share common genomic aberrations and histopathological features, but the former has a more aggressive nature and a higher recurrence rate ...
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
doaj   +1 more source