Results 81 to 90 of about 8,934 (195)

Pan‐Cancer Analysis of the Immunomodulatory Roles and Prognostic Value of PDXP and Experimental Verification in SKCM

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Multiple public databases, including TCGA, GEO, and TARGET, were utilized to comprehensively analyze pyridoxal phosphatase (PDXP) expression profiles across 34 cancer types. We further explored the associations of PDXP expression with clinicopathological features, tumor immune microenvironment, genomic heterogeneity, functional signaling ...
Yingjian Hu, Xinzhu Zeng, Wei Cao, Jianhao Jiao, Yuan Zhao, Jun Wang   +5 more
wiley   +1 more source

p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin. [PDF]

, 2011
Consistent with the excellent clinical results in testicular germ cell tumors (TGCT), most cell lines derived from this cancer show an exquisite sensitivity to Cisplatin. It is well accepted that the high susceptibility of TGCT cells to apoptosis plays a
Weilbacher, A, Aulitzky, WE, van der Kuip, H, Dengler, MA, Markwardt, C, Oren Moshe, Heiko van der Kuip, Michael A Dengler, Michael A. Dengler, Jürgen Thomale, Thomale, J, Aulitzky Walter E., Walter E Aulitzky, Thomale Jürgen, Moshe Oren, van der Kuip Heiko, Matthias Gutekunst, Walter E. Aulitzky, Gutekunst, M, Christiane Markwardt, Markwardt Christiane, Gutekunst Matthias, Andrea Weilbacher, Oren, M, Dengler Michael A., Weilbacher Andrea   +25 more
core   +2 more sources

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

A Thiopurine-like Mutagenic Process Defines TGCT Subtypes

Abstract Testicular germ cell tumors (TGCTs) are the most common malignancy in young men, exhibit a unique developmental origin and exceptional chemosensitivity. However, the molecular distinctions between TGCT subtypes remain poorly understood.
Tongwu Zhang, Kevin Brown, Jun Zhong, Adriana Miranda, Mengyan Zhang, Joycelyn Williams, Jacob Williams, Haoyu Zhang, Cheng Liang, Wenbo Li, Bin Zhu, Stephen J. Chanock, Katherine Nathanson   +12 more
openaire   +2 more sources

Testicular germ cell tumors: tumor grade co-relation with TNS stages and remote metastasis

Journal of Education, Health and Sport, 2019
The performed analysis, based on the examination of pathologists’ reports and medical case histories of the patients of Kharkiv regional clinical center of urology and nephrology named after Shapovalov V.I., for the period covering years 1998-2017, is ...
Serhii M. Potapov, Nataliia I. Horhol, Daria I. Halata, Oksana M. Pliten   +3 more
doaj   +3 more sources

Susceptibilidad genética y exploración molecular en pacientes familiares, bilaterales y esporádicos con tumor testicular germinal (TGCT).

, 2022
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Bioquímica. Fecha de lectura: 25-02-2021Esta tesis tiene embargado el acceso al texto completo hasta el 25-08-2022Testicular Germ Cell Tumours (TGCT)
Martín Gimeno, Paloma
core   +1 more source

Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation?

Zhongliu Fangzhi Yanjiu
Tenosynovial giant cell tumor (TGCT) is a rare mesenchymal tumor that clinically presents as nodular-type or diffuse-type (D-TGCT). D-TGCT is more aggressive, has a higher surgical recurrence rate, and can potentially lead to severe joint destruction ...
Hairong XU, Jing CHEN, Xiaohui NIU
doaj   +1 more source

Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis

Asian Journal of Andrology, 2015
Malignant testicular germ cell tumors (TGCT) are the most frequent cancers in Caucasian males (20-40 years) with an 70% increasing incidence the last 20 years, probably due to combined action of (epi)genetic and (micro)environmental factors.
Jenny E Elzinga-Tinke, Gert R Dohle, Leendert HJ Looijenga   +2 more
doaj   +1 more source

Comprehensive analysis of prominent molecular biomarkers for TGCT diagnostics

, 2020
Since it is important to establish the diagnosis in cases of TGCT as soon as posible, novel molecular biomarkers have been explored.
Krasić, Jure, Raos, Dora, Katušić Bojanac, Ana, Mašić, Silvija, Ulamec, Monika, Ježek, Davor, Sinčić, Nino   +6 more
openaire   +3 more sources

Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology [PDF]

, 2018
Testicular germ cell tumour (TGCT) is the most common cancer in young men. Multiplex TGCT families have been well reported and analyses of population cancer registries have demonstrated a four- to eightfold risk to male relatives of TGCT patients.
Orr, N, Muir, K, Houlston, RS, Law, P, Peto, J, Loveday, C, Pashayan, N, Dunning, AM, Litchfield, K, Reid, A, Eeles, R, Easton, DF, Levy, M, UK Testicular Cancer Collaboration, The PRACTICAL Consortium, Kote-Jarai, Z, Huddart, RA, Broderick, P, Holroyd, A, Turnbull, C, Dudakia, D   +19 more
core   +3 more sources