Results 91 to 100 of about 8,934 (195)

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Cancer heterogeneity explored through immune cell deconvolution of the tumor microenvironment

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Cancer is a highly heterogeneous disease, characterized by significant variability across multiple dimensions. This diversity has been extensively studied from various perspectives. In this study, we aim to examine cancer heterogeneity through the lens of immune cell composition within the tumor microenvironment.
Limin Jiang, Chung‐I Li, Rui Xin, Jijun Tang, Yan Guo   +4 more
wiley   +1 more source

Localized Tenosynovial Giant Cell Tumor After Total Knee Arthroplasty

Arthroplasty Today
Tenosynovial giant cell tumor (TGCT) occurs in both diffuse and localized forms. While diffuse TGCT is an uncommon but well-described complication after total knee arthroplasty (TKA), localized TGCT has only once been previously described as a ...
Nicket Dedhia, MD, Diego Zamata-Ovalle, BS, Emma Johnson, MD, Evan Schwechter, MD   +3 more
doaj   +1 more source

Reduced colony‐stimulating factor 1 receptor expression in myeloid cells has limited impact on chronic lymphocytic leukaemia progression

British Journal of Haematology, Volume 209, Issue 3, Page 939-952, September 2026.
Summary Targeting the colony‐stimulating factor 1 receptor (CSF1R) to remove tumour‐associated macrophages is being explored as cancer therapy. This strategy may be relevant for chronic lymphocytic leukaemia (CLL), which strongly depends on support from myeloid cells.
Natascha Rosen, Guillermo Rodriguez‐Real, Alexander F. vom Stein, Luca D. Schreurs, Trong‐Hieu Nguyen, Viktoria Kohlhas, Thanh‐Tung Truong, Maximilian Koch, Sebastian Reinartz, Sumiya Iqbal, Shaista Ilyas, Sanjay Mathur, Nina Reinart, Phuong‐Hien Nguyen, Michael Hallek   +14 more
wiley   +1 more source

TGCT expression profiling, the road to better diagnostics

, 2019
Testicular germ cell tumors (TGCT) incidence has been continuously rising across the world. Croatia is no exception, with the highest rise in incidence accompanied by a higher rate of mortality compared to other countries. TGCT's make up 95% of testicular tumors and are classified as pure seminoms (SE) and non—seminomas (NS), both considered to ...
Krasić, Jure, Raos, Dora, Mašić, Silvija, Dobrović, Irena, Čorić, Marijana, Krušlin, Božo, Katušić Bojanac, Ana, Bulić-Jakuš, Floriana, Ježek, Davor, Ulamec, Monika, Sinčić, Nino   +10 more
openaire   +2 more sources

Physical morbidities in survivors of testicular germ cell tumors during childhood, adolescence, and young adulthood: a population-based retrospective matched cohort studyResearch in context

EClinicalMedicine
Summary: Background: While testicular germ cell tumors (TGCT) survival exceeds 90%, many survivors of adult TGCT are at risk for treatment toxicities. Less is known about physical morbidities in children, adolescents, and young adults (CAYA) with TGCT ...
Rand Ajaj, Cindy Lau, Sumit Gupta, Nancy N. Baxter, Jason D. Pole, Furqan Shaikh, Paul C. Nathan   +6 more
doaj   +1 more source

Exome Sequencing of Bilateral Testicular Germ Cell Tumors Suggests Independent Development Lineages

Neoplasia: An International Journal for Oncology Research, 2015
Intratubular germ cell neoplasia, the precursor of testicular germ cell tumors (TGCTs), is hypothesized to arise during embryogenesis from developmentally arrested primordial germ cells (PGCs) or gonocytes.
Sigmund Brabrand, Bjarne Johannessen, Ulrika Axcrona, Sigrid M. Kraggerud, Kaja G. Berg, Anne C. Bakken, Jarle Bruun, Sophie D. Fosså, Ragnhild A. Lothe, Gustav Lehne, Rolf I. Skotheim   +10 more
doaj   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, Volume 117, Issue 3, Page 642-652, September 2026.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

MRI Radiomics for Predicting the Diffuse Type of Tenosynovial Giant Cell Tumor: An Exploratory Study

Diagnostics
Objective: To develop and validate a radiomics-based MRI model for prediction of diffuse-type tenosynovial giant cell tumor (D-TGCT), which has higher postoperative recurrence and more aggressive behavior than localized-type (L-TGCT).
Seul Ki Lee, Min Wook Joo, Jee-Young Kim, Mingeon Kim   +3 more
doaj   +1 more source

Glypican 3 (GPC3) expression in a lethal subgroup of refractory cisplatin-resistant testicular germ cell tumor (TGCT).

, 2018
559 Background: The oncofetal protein GPC3 has been tested as a therapy target. Early phase clinical trials established the safety and efficacy of anti-GPC3 chimeric antigen receptor modified T cells in patients with refractory or relapsed GPC3 ...
Song-Chang Lin, Miao Zhang, Sue-Hwa Lin, Jad Chahoud, Shi-Ming Tu   +4 more
core   +1 more source