Results 181 to 190 of about 14,813 (212)

Eugenol Alleviates TGEV-Induced Intestinal Injury via Suppressing ROS/NLRP3/GSDMD–Dependent Pyroptosis

Journal of Agricultural and Food Chemistry, 2023
Transmissible gastroenteritis virus (TGEV), a coronavirus, is one of the main causative agents of diarrhea in piglets and significantly impacts the global swine industry. Pyroptosis is involved in the pathogenesis of coronavirus, but its role in TGEV-induced intestinal injury has yet to be fully elucidated.
Jun He, Xiangbin Mao, Zhiqing Huang
exaly   +3 more sources

Immune response of sows vaccinated with attenuated transmissible gastroenteritis virus (TGEV) and recombinant TGEV spike protein vaccines and protection of their suckling pigs against virulent TGEV challenge exposure

American Journal of Veterinary Research, 1998
Abstract Objective To compare recombinant transmissible gastroenteritis virus (TGEV) spike protein, (SP) R2-2, with attenuated live virus (ALV) vaccine in sows during late pregnancy. Animals 13 TGEV-seronegative sows and their pigs. Procedure At prepartum weeks (PPW) 6 and 4, sows of groups 1 and 2 received ALV via the oral/intranasal (O/IN) route.
S, Park, K, Sestak, D C, Hodgins, D I, Shoup, L A, Ward, D J, Jackwood, L J, Saif   +6 more
openaire   +2 more sources

An Overview of Successful TGEV Vaccination Strategies and Discussion on the Interrelationship between TGEV and PRCV

1994
Porcine respiratory coronavirus (PRCV) is a new variant of TGE with an altered pathogenesis. PRCV multiplies mainly in tonsilar tissues and the respiratory tract. There are no enteric symptoms and in experimentally infected pigs, even the respiratory tract infection is usually asymptomatic.
M W, Welter, M P, Horstman, C J, Welter, L M, Welter   +3 more
openaire   +2 more sources

Characterization of the Transmissible Gastroenteritis Virus (TGEV) Transcription Initiation Sequence

1995
The ability of the TGEV transcription initiation sequence (TIS) to produce subgenomic RNAs was investigated by placing a reporter gene, chloramphenicol acetyltransferase (CAT) under the control of either the mRNA 6 or the mRNA 7 TISs. Both constructs only produced CAT in TGEV infected cells and the amount of CAT produced from the mRNA 7 TIS was less ...
J A, Hiscox, K L, Mawditt, D, Cavanagh, P, Britton   +3 more
openaire   +2 more sources

Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV [PDF]

Nature, 1992
Coronaviruses, like many animal viruses, are characterized by a restricted host range and tissue tropism. Transmissible gastroenteritis virus (TGEV), a major pathogen causing a fatal diarrhoea in newborn pig, replicates selectively in the differentiated enterocytes covering the villi of the small intestine.
Delmas, Bernard, Gelfi, Jacqueline, L'Haridon, R., Vogel, L.K., Sjöström, H., Noren, O., Laude, Hubert   +6 more
exaly   +5 more sources

MAb Targeting a Link Between ExoN and MTase of TGEV NSP14

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2023
Porcine transmissible gastroenteritis virus (TGEV) infection results in severe gastrointestinal disease manifesting vomiting, diarrhea in neonatal porcine, with extremely high mortality. Monoclonal antibody (MAb) specific to TGEV nonstructural protein (NSP)14 that contains two functional domains, exonuclease (ExoN) and methyltransferase (MTase) domains,
Lilan, Xie, Fang, Lin, Peiling, Dong, Yaoming, Li   +3 more
openaire   +2 more sources

Expression of TGEV Structural Genes in Virus Vectors

1990
TGEV is a Coronavirus that causes gastroenteritis in pigs, resulting in a high mortality of neonates. The TGEV virion contains three major structural polypeptides; a surface glycoprotein (spike or peplomer protein) with a monomeric Mr 200000, a glycosylated integral membrane protein observed as a series of polypeptides of Mr 28000–31000 and a basic ...
D J, Pulford, P, Britton, K W, Page, D J, Garwes   +3 more
openaire   +2 more sources

Recombinant Expression of the TGEV Membrane Glycoprotein M

1995
We have previously shown that the membrane protein M of TGEV is involved in efficient induction of alpha interferon (IFN alpha) synthesis by non-immune peripheral blood mononuclear cells incubated with fixed, TGEV-infected cells or inactivated virions.
P, Baudoux, B, Charley, H, Laude
openaire   +2 more sources

Antigenic variation among transmissible gastroenteritis virus (tgev) and porcine respiratory coronavirus strains detected with monoclonal antibodies to the S protein of tgev

American Journal of Veterinary Research, 1992
Summary Five nonneutralizing monoclonal antibodies (MAb) generated to the virulent Miller strain of transmissible gastroenteritis virus (tgev) and specific for the S protein were characterized. Competition assays between purified and biotinylated MAb indicated that MAb 75B10 and 8G11 mapped near a new subsite, designated V and 2 MAb, 44C11 and 45A8 ...
R A, Simkins, P A, Weilnau, J, Bias, L J, Saif   +3 more
openaire   +2 more sources

Active and passive immune responses to transmissible gastroenteritis virus (TGEV) in swine inoculated with recombinant baculovirus-expressed TGEV spike glycoprotein vaccines

American Journal of Veterinary Research, 1997
Abstract Objective Baculovirus-expressed transmissible gastroenteritis virus (TGEV) spike (S) glycoprotein vaccines were inoculated parenterally in swine to determine whether such vaccines could induce serum and whey virus-neutralizing (VN) antibodies and protective lactogenic immunity for TGEV-challenge-exposed pigs.
D I, Shoup, D J, Jackwood, L J, Saif
openaire   +2 more sources