Results 1 to 10 of about 82,660 (245)
All-trans Retinoic Acid–Induced Isolated Myocarditis
JACC: Case Reports, 2020 All-trans retinoic acid (ATRA) is the mainstay of treatment in patients with acute promyelocytic leukemia. Despite being effective, it can lead to cardiac complications either as a component of ATRA syndrome or an isolated form denominated as ATRA ...
Ugur Nadir Karakulak, MD +5 more
doaj +2 more sources
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion [PDF]
Nature Communications, 2016 Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homeostasis of the tumour microenvironment. Here the authors show that all-trans retinoic acid reduces retinoic acid receptor beta dependent-actomyosin contractility ...
Antonios Chronopoulos +10 more
doaj +3 more sources
All-trans-retinoic acid nanodisks [PDF]
International Journal of Pharmaceutics, 2007 Nanodisks are nanoscale, disk-shaped phospholipid bilayers whose edge is stabilized by association of apolipoprotein molecules. Self-assembled ND particles enriched with all-trans-retinoic acid (ATRA) (phospholipid:ATRA molar ratio = 5.5:1) were generated wherein all reaction components were solubilized.
Katherine A, Redmond +2 more
openaire +2 more sources
Effects of diet and strain on mouse serum and tissue retinoid concentrations. [PDF]
PLoS ONE, 2014 The relationship between dietary vitamin A and all-trans-retinoic acid levels in serum and tissues had not been quantified. We determined the impact of dietary vitamin A on retinoid levels in serum, liver, kidney, testis, and epididymal white adipose of ...
Kristin M Obrochta +2 more
doaj +1 more source
Potential Therapeutic Effect of All-Trans Retinoic Acid on Atherosclerosis
Biomolecules, 2022 Atherosclerosis is a major risk factor for myocardial infarction and ischemic stroke, which are the leading cause of death worldwide. All-trans retinoic acid (ATRA) is a natural derivative of essential vitamin A.
Qile Deng, Jixiang Chen
doaj +1 more source
Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells [PDF]
, 2020 Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells.
Bilip, Maja +11 more
core +4 more sources
Haematologica, 2019 Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu +9 more
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Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes. [PDF]
, 2020 This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis
Roberts, C
core +2 more sources
All-Trans-Retinoic Acid andBleeding/Thrombosis [PDF]
Pathophysiology of Haemostasis and Thrombosis, 2003 Hematology-Oncology Department Ospedali Riuniti Largo Barozzi, 1 24128 Bergamo (Italy) Tel. 39 035 269492, Fax 39 035 266659 E-Mail annafalanga@yahoo.com All-trans-retinoic acid (ATRA) inhibits cell growth and proliferation by inducing cyto-differentiation and/or apoptosis in several cell types.
Anna Falanga +2 more
openaire +1 more source
Haematologica, 2008 Background The clinical activities of all-trans retinoic acid in the treatment of acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia, have triggered extensive studies aimed at defining the mechanisms by which this compound induces ...
Jing Zhang +5 more
doaj +1 more source