Results 11 to 20 of about 82,660 (245)

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

All-trans retinoic acid regulates hepatic bile acid homeostasis [PDF]

Biochemical Pharmacology, 2014
Retinoic acid (RA) and bile acids share common roles in regulating lipid homeostasis and insulin sensitivity. In addition, the receptor for RA (retinoid x receptor) is a permissive partner of the receptor for bile acids, farnesoid x receptor (FXR/NR1H4). Thus, RA can activate the FXR-mediated pathway as well.
Yang, Fan, He, Yuqi, Liu, Hui-Xin, Tsuei, Jessica, Jiang, Xiaoyue, Yang, Li, Wang, Zheng-Tao, Wan, Yu-Jui Yvonne   +7 more
openaire   +6 more sources

Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis. [PDF]

PLoS ONE, 2013
OBJECTIVES: Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration.
Wenjuan Bi, Zhiyuan Gu, Yuanna Zheng, Xiao Zhang, Jing Guo, Gang Wu   +5 more
doaj   +1 more source

Spin Manipulation by Creation of Single-Molecule Radical Cations [PDF]

, 2015
All-trans-retinoic acid (ReA), a closed-shell organic molecule comprising only C, H, and O atoms, is investigated on a Au(111) substrate using scanning tunneling microscopy and spectroscopy.
Berndt, Richard, Diller, Katharina, He, Yang, Hong, I-Po, Karan, Sujoy, Li, Na, Lü, Jing-Tao, Maurer, Reinhard J., Michelitsch, Georg S., Peng, Lianmao, Reuter, Karsten, Song, Huanjun, Wang, Yongfeng, Weismann, Alexander, Wu, Kai, Zhang, Yajie   +15 more
core   +3 more sources

Retinoic Acid and Its Derivatives in Skin

Cells, 2020
The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are ...
Łukasz Szymański, Rafał Skopek, Małgorzata Palusińska, Tino Schenk, Sven Stengel, Sławomir Lewicki, Leszek Kraj, Paweł Kamiński, Arthur Zelent   +8 more
doaj   +1 more source

13-cis-retinoic acid is an endogenous compound in human serum.

Journal of Lipid Research, 1990
The occurrence of 13-cis-retinoic acid as an endogenous component in human serum has been confirmed by cochromatography with standards in both normal-phase and reverse-phase high-performance liquid chromatographic (HPLC) system, by the lambda max of its ...
GW Tang, RM Russell
doaj   +1 more source

Identification of the Retinoic Acid-inducible All-trans-retinoic Acid 4-Hydroxylase [PDF]

Journal of Biological Chemistry, 1996
Retinoic acid (RA) metabolites of vitamin A are key regulators of gene expression involved in embryonic development and maintenance of epithelial tissues. The cellular effects of RA are dependent upon the complement of nuclear receptors expressed (RARs and RXRs), which transduce retinoid signals into transcriptional regulation, the presence of cellular
J A, White, Y D, Guo, K, Baetz, B, Beckett-Jones, J, Bonasoro, K E, Hsu, F J, Dilworth, G, Jones, M, Petkovich   +8 more
openaire   +2 more sources

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Beez, Sabine, Demmer, Philipp, Puccetti, Elena   +2 more
core   +7 more sources

Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma.

Journal of Lipid Research, 1990
Human plasma was analyzed by high performance liquid chromatography for the presence of retinoic acid and 4-oxoretinoic acid isomers. Peaks that coeluted with the reference compounds all-trans-retinoic acid, 13-cis-retinoic acid, and 13-cis-4-oxoretinoic
C Eckhoff, H Nau
doaj   +1 more source

All-Trans Retinoic Acid plus Arsenic Trioxide versus All-Trans Retinoic Acid plus Chemotherapy for Newly Diagnosed Acute Promyelocytic Leukemia: A Meta-Analysis. [PDF]

PLoS ONE, 2016
Recently, the all-trans retinoic acid (ATRA) plus arsenic trioxide (ATO) protocol has become a promising first-line therapeutic approach in patients with newly diagnosed acute promyelocytic leukemia (APL), but its benefits compared with standard ATRA ...
Yafang Ma, Lu Liu, Jie Jin, Yinjun Lou
doaj   +1 more source