Results 1 to 10 of about 43,912 (220)

Acute Promyelocytic Leukemia in Four Year Old Female Child - A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2014
Leukemia is the most common malignancy of childhood representing about 30 % of oncohematological diseases diagnosed in children less than 15 years of age.
Anirudha V. Kushtagi, Mihir J. Bhalodia, Mahesh H. Karigoudar, Jyotirling Savle   +3 more
doaj   +2 more sources

TGFβ-Mediated Overexpression of Podoplanin Serves as a Potential Diagnostic Biomarker in Acute Promyelocytic Leukemia. [PDF]

Mol Carcinog
ABSTRACT Early diagnosis of acute promyelocytic leukemia (APL), driven by PML‐RARA oncoprotein, is vital for survival, as delays can cause fatal coagulopathy without prompt therapeutic intervention of all‐trans retinoic acid and arsenic trioxide. Although APL is diagnosed using microscopy, immunophenotyping, and FISH/PCR for PML‐RARA, morphological ...
Maity A, Kumar R, Dutta M, Mishra A, Gawde J, Patil J, Kadam D, Mirgh S, Gokarn A, Jain H, Nayak L, Bagal B, Punatar S, Sengar M, Khattry N, Subramanian PG, Tembhare P, Hasan SK.   +17 more
europepmc   +2 more sources

Acute Promyelocytic Leukemia [PDF]

Cancers, 2020
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion between the promyelocytic leukemia (PML) gene and retinoic acid receptor-α (RARα) [...]
Xavier Thomas, Maël Heiblig
  +6 more sources

Acute Promyelocytic Leukemia Presenting With a Myeloid Sarcoma of the Spine: A Case Report and Literature Review

Frontiers in Oncology, 2022
Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. Certain known acute myeloid leukemia cytogenetic abnormalities, in particular t(8,21), has been associated with a higher incidence.
Xuemei Shu, Qiuling Wu, Tao Guo, Hua Yin, Jingdi Liu   +4 more
doaj   +1 more source

Addition of Arsenic Trioxide into Induction Regimens Could Not Accelerate Recovery of Abnormality of Coagulation and Fibrinolysis in Patients with Acute Promyelocytic Leukemia. [PDF]

PLoS ONE, 2016
AIM:All-trans retinoic acid combined to anthracycline-based chemotherapy is the standard regimen of acute promyelocytic leukemia. The advent of arsenic trioxide has contributed to improve the anti-leukemic efficacy in acute promyelocytic leukemia.
Ye Zhang, SiJing Wu, Dan Luo, JianFeng Zhou, DengJu Li   +4 more
doaj   +1 more source

Extramedullary acute promyelocytic leukemia [PDF]

Cancer, 1996
Extramedullary acute promyelocytic leukemia (APL) is rare, and said to be more common after treatment with all-trans retinoic acid (ATRA) than after any other treatment.The case of a child with extramedullary relapse of APL after initial treatment with ATRA and that of an adult whose initial treatment was chemotherapy are presented, and the literature ...
P H, Wiernik, R, De Bellis, P, Muxi, J P, Dutcher   +3 more
openaire   +2 more sources

Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism

Haematologica, 2020
Obesity correlates with hematologic malignancies including leukemias, but risk of specific leukemia subtypes like acute promyelocytic leukemia and underlying molecular mechanisms are poorly understood.
Luca Mazzarella, Edoardo Botteri, Anthony Matthews, Elena Gatti, Davide Di Salvatore, Vincenzo Bagnardi, Massimo Breccia, Pau Montesinos, Teresa Bernal, Cristina Gil, Timothy J Ley, Miguel Sanz, Krishnan Bhaskaran, Francesco Lo Coco, Pier Giuseppe Pelicci   +14 more
doaj   +1 more source

Treatment of Central Nervous System Relapse in Acute Promyelocytic Leukemia by Venetoclax: A Case Report

Frontiers in Oncology, 2021
Extramedullary relapse of acute promyelocytic leukemia is a rare phenomenon and is associated with a poor prognosis, with the central nervous system being the most common site of relapse. The current treatments are still limited.
Xuzhao Zhang, Jinliang Chen, Weiqin Wang, Xian Li, Yanbin Tan, Xiaohong Zhang, Wenbin Qian   +6 more
doaj   +1 more source

Acute promyelocytic leukemia

Journal of Nepal Paediatric Society, 2018
Acute promyelocytic leukemia (APL) is the most malignant form of acute leukemia, relatively uncommon in children, rapidly fatal if untreated and several developments have paved the way to make this disease curable. We report a first case to our knowledge in Nepal, a 12 years old boy who was diagnosed as APL and treated with vesanoid 14 years back and ...
Yuranga Weerakkody, Bruno Di Muzio, Daniel Bell   +2 more
  +6 more sources

SECONDARY ACUTE PROMYELOCYTIC LEUKEMIA DEVELOPED AFTER TREATMENT OF NON-HODGKIN'S LYMPHOMA. CLINICAL CASE AND REVIEW OF LITERATURE.

Arta Medica, 2020
Background: Acute promyelocytic leukemia is an acute myeloid leukemia that accounts approximately 10% of acute myeloid leukemia cases. Acute promyelocytic leukemias usually appears as a de novo finding.
Victor Tomacinschii, Maria Robu, Vasile Musteață, Irina Mocanu, Sanda Buruiană, Natalia Sporîș, Veronica Feghiu   +6 more
doaj   +1 more source