Results 11 to 20 of about 21,951 (195)

Primary Extramedullary Acute Promyelocytic Leukemia Presenting as Cauda Equina Syndrome: A Rare Case Report and Diagnostic Challenge. [PDF]

Clin Case Rep
ABSTRACT APL presenting as an extramedullary mass is exceedingly rare. Here, we describe extramedullary APL causing cauda equina syndrome, underscoring the diagnostic challenges associated with an atypical presentation, highlighting the complexity of distinguishing extramedullary APL from other conditions, and discussing the stepwise approach to ...
Ali A, Ringor M, Khalid A, Garcia D, Konchada R, Ratnasabapathy R, Chae Y, Melikyan A, Yaghmour G.   +8 more
europepmc   +2 more sources

Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature

Hematology/Oncology and Stem Cell Therapy, 2018
Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to ...
Iman Abou Dalle, Samer Nassif, Ali Bazarbachi   +2 more
doaj   +1 more source

Extramedullary acute promyelocytic leukemia [PDF]

Cancer, 1996
Extramedullary acute promyelocytic leukemia (APL) is rare, and said to be more common after treatment with all-trans retinoic acid (ATRA) than after any other treatment.The case of a child with extramedullary relapse of APL after initial treatment with ATRA and that of an adult whose initial treatment was chemotherapy are presented, and the literature ...
P H, Wiernik, R, De Bellis, P, Muxi, J P, Dutcher   +3 more
openaire   +2 more sources

The relevance of preferentially expressed antigen of melanoma (PRAME) as a marker of disease activity and prognosis in acute promyelocytic leukemia

Haematologica, 2008
Background The gene for preferentially expressed antigen of melanoma (PRAME) has been shown to be over-expressed in acute promyelocytic leukemia, but its actual incidence and clinical impact are still unknown.Design and Methods We studied PRAME ...
Carlos Santamaría, María Carmen Chillón, Ramón García-Sanz, Ana Balanzategui, María Eugenia Sarasquete, Miguel Alcoceba, Fernando Ramos, Teresa Bernal, José Antonio Queizán, María Jesús Peñarrubia, Pilar Giraldo, Jesús F. San Miguel, Marcos Gonzalez   +12 more
doaj   +1 more source

Efficacy and the Adverse Effects of Oral Versus Intravenous Arsenic for Acute Promyelocytic Leukemia: A Meta-Analysis of Randomized-Controlled Studies

Technology in Cancer Research & Treatment, 2020
Acute promyelocytic leukemia, a subtype of acute myeloid leukemia, is highly curable. In subgroup of patients with non-high-risk acute promyelocytic leukemia, intravenous arsenic trioxide plus all-trans-retinoic acid is considered the preferred regimen ...
Natthaporn Sasijareonrat MD, Nikolaus Jahn MD, Patompong Ungprasert MD, MS, Weerapat Owattanapanich MD   +3 more
doaj   +1 more source

Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia

Case Reports in Dermatology, 2012
Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression.
Sachiko Sakamoto, Naoki Oiso, Masakatsu Emoto, Shusuke Uchida, Ayaka Hirao, Yoichi Tatsumi, Itaru Matsumura, Akira Kawada   +7 more
doaj   +1 more source

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid ...
Sarah Cristina Bassi, Eduardo Magalhães Rego   +1 more
doaj   +1 more source

Notch signaling in acute promyelocytic leukemia [PDF]

Leukemia, 2013
Acute promyelocytic leukemia (APL) is initiated by the PML-RARA (PR) fusion oncogene and has a characteristic expression profile that includes high levels of the Notch ligand Jagged-1 (JAG1). In this study, we used a series of bioinformatic, in vitro, and in vivo assays to assess the role of Notch signaling in human APL samples, and in a PML-RARA knock-
Grieselhuber, Nicole R., Klco, Jeffery M., Verdoni, Angela M., Lamprecht, Tamara, Sarkaria, Shawn M., Wartman, Lukas D., Ley, Timothy J.   +6 more
openaire   +2 more sources

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA

Haematologica, 2016
The PML/RARA fusion protein occurs as a result of the t(15;17) translocation in the acute promyelocytic leukemia subtype of human acute myeloid leukemia.
Karen Keeshan, Pauline Vieugué, Shahzya Chaudhury, Loveena Rishi, Coline Gaillard, Lu Liang, Elaine Garcia, Takuro Nakamura, Nader Omidvar, Scott C. Kogan   +9 more
doaj   +1 more source

Acute Promyelocytic Leukemia in Four Year Old Female Child - A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2014
Leukemia is the most common malignancy of childhood representing about 30 % of oncohematological diseases diagnosed in children less than 15 years of age.
Anirudha V. Kushtagi, Mihir J. Bhalodia, Mahesh H. Karigoudar, Jyotirling Savle   +3 more
doaj