Results 11 to 20 of about 1,571,497 (188)

Additional chromosome abnormalities in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy [PDF]

Haematologica, 2010
Background Acute promyelocytic leukemia is a subtype of acute myeloid leukemia characterized by the t(15;17). The incidence and prognostic significance of additional chromosomal abnormalities in acute promyelocytic leukemia is still a controversial ...
José Cervera, Pau Montesinos, Jesús M. Hernández-Rivas, María J. Calasanz, Anna Aventín, María T. Ferro, Elisa Luño, Javier Sánchez, Edo Vellenga, Chelo Rayón, Gustavo Milone, Javier de la Serna, Concha Rivas, José D. González, Mar Tormo, Elena Amutio, Marcos González, Salut Brunet, Bob Lowenberg, Miguel A. Sanz   +19 more
doaj   +4 more sources

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610), Beez, Sabine, Philipp Demmer, Elena Puccetti (66633), Philipp Demmer (123611), Puccetti, Elena, Elena Puccetti, Sabine Beez, Demmer, Philipp   +8 more
core   +1 more source

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia [PDF]

, 2005
The prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established and is of particular interest given the opportunities for targeted therapies using FLT3 inhibitors.
Gilkes, Amanda F., Ellen Solomon, Linch, D C, Gale, Rosmary E., Burnett, Alan Kenneth, Gale, RE, David C. Linch, Pizzey, AR, Elizabeth Nugent, Keith Wheatley, Grimwade, D., Grimwade, D, Solomon, E, Pizzey, A R, Solomon, Ellen, Kenneth I. Mills, Swirsky, D, Pizzey, A.R., Burnett, A K, Alan K. Burnett, Hills, Robert Kerrin, Swirsky, David, Kottaridis, Panagiotis D., Grimwade, David, Linch, David C., ?, ?, Hills, R., David Swirsky, Gale, R E, Gilkes, A F, Kottaridis, PD, Solomon, E., Robert Hills, Linch, D.C., Arnold R. Pizzey, Nugent, E., Rosemary E. Gale, Mills, KI, Nugent, Elizabeth, Gale, R.E., Swirsky, D., Hills, Robert, Hills, R, NCRI Adult Leukaemia Working Party, David Grimwade, Kottaridis, P D, Linch, DC, Wheatley, K., Amanda F. Gilkes, Wheatley, Keith, Gilkes, AF, Nugent, E, Panagiotis D. Kottaridis, Mills, K I, Mills, Ken; id_orcid, Kottaridis, P.D., Burnett, AK, Burnett, A.K., Mills, Kenneth I., Gilkes, A.F., Wheatley, K, Pizzey, Arnold R.   +61 more
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Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Mittermueller, J., Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, S., Wiesner, D., Duell, T., J. Mittermueller, D. Wiesner, S. Braun, H.M. Schmetzer, T. Duell, H.H. Gerhartz   +11 more
core   +1 more source

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]

, 2014
Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Hands, K.J., Hay, Ronald T., Everett, R.D., Hay, R.T., Hands, Katherine J., Cuchet-Lourenco, Delphine, Everett, Roger D., Cuchet-Lourenco, D.   +7 more
core   +1 more source

Optimization of the indications for allogeneic stem cell transplantation in Acute Myeloid Leukemia based on interactive diagnostic strategies [PDF]

, 2011
The indications for allogeneic stem cell transplantation (SCT) in Acute Myeloid Leukemia (AML) represent a real challenge due to the clinical and genetic heterogeneity of the disorder.
Hartwig, Maite, Zander, Axel R., Haferlach, Torsten, Fehse, Boris, Bacher, Ulrike, Kröger, Nicolaus   +5 more
core   +1 more source

Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature

Hematology/Oncology and Stem Cell Therapy, 2018
Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to ...
Iman Abou Dalle, Samer Nassif, Ali Bazarbachi   +2 more
doaj   +1 more source

Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

Hematology, 2003
AbstractThe therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as
Bob, Löwenberg, James D, Griffin, Martin S, Tallman   +2 more
openaire   +2 more sources

The relevance of preferentially expressed antigen of melanoma (PRAME) as a marker of disease activity and prognosis in acute promyelocytic leukemia

Haematologica, 2008
Background The gene for preferentially expressed antigen of melanoma (PRAME) has been shown to be over-expressed in acute promyelocytic leukemia, but its actual incidence and clinical impact are still unknown.Design and Methods We studied PRAME ...
Carlos Santamaría, María Carmen Chillón, Ramón García-Sanz, Ana Balanzategui, María Eugenia Sarasquete, Miguel Alcoceba, Fernando Ramos, Teresa Bernal, José Antonio Queizán, María Jesús Peñarrubia, Pilar Giraldo, Jesús F. San Miguel, Marcos Gonzalez   +12 more
doaj   +1 more source

Efficacy and the Adverse Effects of Oral Versus Intravenous Arsenic for Acute Promyelocytic Leukemia: A Meta-Analysis of Randomized-Controlled Studies

Technology in Cancer Research & Treatment, 2020
Acute promyelocytic leukemia, a subtype of acute myeloid leukemia, is highly curable. In subgroup of patients with non-high-risk acute promyelocytic leukemia, intravenous arsenic trioxide plus all-trans-retinoic acid is considered the preferred regimen ...
Natthaporn Sasijareonrat MD, Nikolaus Jahn MD, Patompong Ungprasert MD, MS, Weerapat Owattanapanich MD   +3 more
doaj   +1 more source