Results 21 to 30 of about 1,571,497 (188)

Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia

Case Reports in Dermatology, 2012
Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression.
Sachiko Sakamoto, Naoki Oiso, Masakatsu Emoto, Shusuke Uchida, Ayaka Hirao, Yoichi Tatsumi, Itaru Matsumura, Akira Kawada   +7 more
doaj   +1 more source

Identification of cooperating genetic events in acute leukemia [PDF]

, 2009
The genetic alterations associated with acute leukemia can be divided into two functional groups. The class I mutations enhance cellular proliferation and survival by constitutive activation of mainly protein tyrosine kinases signaling pathways.
Liu, Ting
core   +1 more source

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid ...
Sarah Cristina Bassi, Eduardo Magalhães Rego   +1 more
doaj   +1 more source

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA

Haematologica, 2016
The PML/RARA fusion protein occurs as a result of the t(15;17) translocation in the acute promyelocytic leukemia subtype of human acute myeloid leukemia.
Karen Keeshan, Pauline Vieugué, Shahzya Chaudhury, Loveena Rishi, Coline Gaillard, Lu Liang, Elaine Garcia, Takuro Nakamura, Nader Omidvar, Scott C. Kogan   +9 more
doaj   +1 more source

Predictors of early death, serious hemorrhage, and differentiation syndrome in Japanese patients with acute promyelocytic leukemia.

, 2020
Significant advancements have been achieved with regard to the outcomes of acute promyelocytic leukemia (APL) patients through the introduction of all-trans retinoic acid; however, early hemorrhagic death and differentiation syndrome remain the major ...
8178, 8179, 8176, 8177, OHTAKE, Shigeki, 8170, 8171, 8174, USUI, Noriko, 8175, 8172, 8173, 0000-0003-4450-0106, 8189, 8187, 8188, FUJIMAKI, Katsumichi, KIYOI, Hitoshi, 8181, 8182, TAKESHITA, Akihiro, 8180, 8185, 8186, 8183, 8184, NAOE, Tomoki, 806, TANIGUCHI, Yasuhiro, YANADA, Masamitsu, MINAMIGUCHI, Hitoshi, SAWA, Masashi, MIYAZAKI, Yasushi, SAKURA, Toru, UEDA, Yasunori, 8190, 8191, 0000-0001-7504-6677, MATSUMURA, Itaru, FUJITA, Hiroyuki, DOBASHI, Nobuaki, 0000-0003-2378-7865, 8167, 8168, ASOU, Norio, 8169, IWANAGA, Masako, ATSUTA, Yoshiko, SUZUKI, Rikio, HAGIHARA, Maki, TAMAKI, Shigehisa, 南口, 仁志, UCHINO, Yoshihito, TOMITA, Akihiro, MAEDA, Yoshinobu, KOBAYASHI, Yukio   +55 more
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Acute promyelocytic leukemia

, 2018
Acute promyelocytic leukemia (APL) is the most malignant form of acute leukemia, relatively uncommon in children, rapidly fatal if untreated and several developments have paved the way to make this disease curable. We report a first case to our knowledge
Yuranga Weerakkody, Bruno Di Muzio, Daniel Bell   +2 more
core   +3 more sources

Chlorination‐Driven BODIPY Fluorescent Probes for the Selective Monitoring of Myeloperoxidase Activity in Cells and Inflamed Mouse Models

Angewandte Chemie, EarlyView.
A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho, Yongyang Luo, Jeehyeon Bae, Youngmi Kim   +3 more
wiley   +2 more sources

High-Resolution Genome-Wide Single Nucleotide Polymorphism Mapping in Acute Myeloid Leukaemia [PDF]

, 2008
PhDInvestigation of the genetics of acute myeloid leukaemia (AML) has revealed the underlying basis of the disease and led to targets for therapy. High-resolution single nucleotide polymorphism (SNP) arrays detected regions of loss of heterozygosity ...
Raghavan, Manoj
core   +4 more sources

Notch signaling in acute promyelocytic leukemia [PDF]

Leukemia, 2013
Acute promyelocytic leukemia (APL) is initiated by the PML-RARA (PR) fusion oncogene and has a characteristic expression profile that includes high levels of the Notch ligand Jagged-1 (JAG1). In this study, we used a series of bioinformatic, in vitro, and in vivo assays to assess the role of Notch signaling in human APL samples, and in a PML-RARA knock-
Grieselhuber, Nicole R., Klco, Jeffery M., Verdoni, Angela M., Lamprecht, Tamara, Sarkaria, Shawn M., Wartman, Lukas D., Ley, Timothy J.   +6 more
openaire   +2 more sources

Acute Promyelocytic Leukemia in Four Year Old Female Child - A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2014
Leukemia is the most common malignancy of childhood representing about 30 % of oncohematological diseases diagnosed in children less than 15 years of age.
Anirudha V. Kushtagi, Mihir J. Bhalodia, Mahesh H. Karigoudar, Jyotirling Savle   +3 more
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