Results 191 to 200 of about 320,405 (317)

TGF-β and TNF-α Signaling Crosstalk in Human Coronary Artery Cells. [PDF]

Int J Mol Sci
Bonowicz-Kozłowska K, Jerka D, Twardak D, Kleszczyński K, Gagat M.   +4 more
europepmc   +1 more source

Mouse Hepatic Oval Cells Require Met-Dependent PI3K to Impair TGF-β-Induced Oxidative Stress and Apoptosis

, 2013
Adoración Martínez‐Palacián, Gaelle del Castillo, Amileth Suárez Causado, María García‐Álvaro, Diego de la Morena-Frutos, Margarita Fernández, Cesáreo Roncero, Isabel Fabregat, Blanca Herrera, Aranzazu Sánchez   +9 more
openalex   +2 more sources

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Exploring the Complexities of TGF-β Signaling in Keloids: Beyond the Classical Smad Pathway. [PDF]

Int J Mol Sci
Mo J, Huang H, Zhu B, Liao R, Li W, Zhang Y.   +5 more
europepmc   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling. [PDF]

Hypertension
Zeng J, Li D, Wang J, Wang R, Huang Z, Bai D, Liu X, Sun D, Fu G, Kang K, Liu X, Yang L, Zhao F, Luo L, Li R, Zhang Y, Gou D.   +16 more
europepmc   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

Recent advances in TGF-β signaling: insights into regulation, pathophysiological function, and clinical translation. [PDF]

Cell Regen
Yan X, Zhang J, Heldin CH, Feng XH, Chen YG.   +4 more
europepmc   +1 more source

Rhein‑8‑O‑β‑D‑glucopyranoside inhibited high glucose‑induced apoptosis of human mesangial cells by regulating the lincRNA ANRIL/let‑7a/TGF‑β1/Smad signaling pathway

, 2020
Lansheng Zhang, Jing Li, Jiaping Liu
openalex   +2 more sources

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source