Results 191 to 200 of about 2,112,620 (360)

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Effects of transforming growth factor β on β1 integrin expression and localization during myogenesis in chicken [PDF]

, 2006
Myoblast-extracellular environment interactions are mediated by the integrin family of cell adhesion receptors. Integrins have been shown to play a pivotal role in skeletal muscle development.
Li, Xuehui
core  

Additional file 1: of The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma

, 2019
Figure S1. LEF1 and ID1 expression in ESCC samples and the transcription of ID1 is regulated by LEF1. (A) LEF1 and ID1 staining by IHC in ESCC TMAs were showed. Upper panel was used for analysis of expression association between LEF1 and ID1.A total of 243 LEF1 staining patients were used for clinicopathological characteristics analysis.
Zhao, Yue, Zhu, Ji, Shi, Bowen, Wang, Xinyu, Lu, Qijue, Li, Chunguang, Chen, Hezhong   +6 more
openaire   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Multi-omics profiling of TGF-β isoforms and regulatory miRNAs in astrocytic tumors reveals TGF-β-3 as a prognostic biomarker

Frontiers in Oncology
BackgroundAstrocytic tumors, particularly glioblastomas, are aggressive brain malignancies with poor prognosis. Transforming growth factor-beta (TGF-β) isoforms—TGF-β-1, TGF-β-2, and TGF-β-3—play critical roles in glioma progression, yet their isoform ...
Klaudia Skóra, Klaudia Skóra, Damian Strojny, Damian Strojny, Damian Strojny, Dawid Sobański, Dawid Sobański, Rafał Staszkiewicz, Rafał Staszkiewicz, Rafał Staszkiewicz, Kamil Bryś, Paweł Gogol, Paweł Gogol, Paweł Gogol, Paweł Gogol, Krzysztof Bereza, Krzysztof Bereza, Michalina Masternak, Beniamin Oskar Grabarek, Beniamin Oskar Grabarek   +19 more
doaj   +1 more source

In situ analysis of transforming growth factor-βs (TGF-β1, TGF-β2, TGF-β3and TGF-3 type II receptor expression in malignant melanoma [PDF]

, 2017
We have analysed, by in situ hybridization, mRNA expression of TGF-β1, TGF-β2, TGF-β3, and of TGF-β type II receptor in benign melanocytic naevi, primary melanomas, and in skin metastases of malignant melanomas. Our results show that melanoma progression
Itin, Peter, Rufli, Theo, Schmid, Peter
core  

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post‐Acute Phase Wound Healing

Advanced Healthcare Materials, EarlyView.
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess, Ellen F. Marsh, Veronica M. Lucian, Malavika Nair   +3 more
wiley   +1 more source

Additional file 2: of The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma

, 2019
Table S1. Correlation between LEF1 expression and clinicopathological characteristics in 243 patients. Table S2. Correlation between LEF1 expression and clinicopathological characteristics in total 338 patients. (DOCX 21 kb)
Zhao, Yue, Zhu, Ji, Shi, Bowen, Wang, Xinyu, Lu, Qijue, Li, Chunguang, Chen, Hezhong   +6 more
openaire   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source