Results 151 to 160 of about 1,017,685 (306)

Characterization of TGF-beta inhibition of an in-vitro 3D mouse model of early post-implantation development

reservedTGF-β signaling, in specific Nodal, is known to play a crucial role during early mouse embryonic development, regulating tissue patterning and axis formation.
DE JUAMBELZ URÍAS, SUSANA
core  

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells

, 2015
Lijun Zhang, Jie Zhang, Changgeng Xu, Xiangjun Zhou, Wei Wang, Renping Zheng, Wei Hu, Pin Wu Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of China Abstract: Fibroblast activation and ...
Zhou XJ, Zhang J, Zheng RP, Hu W, Zhang LJ, Wu P, Xu CG, Wang W   +7 more
core  

A recurrent cancer-associated fibroblast/TGF-beta/endothelial barrier direction is associated with immune exclusion and checkpoint resistance in bladder cancer: a public multi-cohort transcriptomic study. [PDF]

PLoS One
Wu Y, Li G, Jiang L, Zhang C, Fang H, Fan H.   +5 more
europepmc   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

TGF-beta promotes human T follicular helper cell stemness properties at the expense of effector function. [PDF]

Front Immunol
Yang Y, Wu C, Yang W, Peng L, Zhang Y, Zheng X, Wang Y, Jin K, Liu W.   +8 more
europepmc   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Oncogenic role of talin-1 in glioma: Association with poor prognosis and regulation of the TGF-beta signaling pathway. [PDF]

Transl Oncol
Li J, Zhang D, Zhou H, Hou L, Wang Y, Zhang Z, Wang Y, Li X, Yi L, Liu X, Wang Y, Xue X.   +11 more
europepmc   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Estrogen upregulates NR4A1 to counter TGF beta induced pulmonary fibrosis therapeutic insights for IPF. [PDF]

iScience
Liu B, Chi H, Jiang T, Wang X, Cao F, Zhang R, Liu Z, Hu X.   +7 more
europepmc   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source